Gene name: CHEK1
Protein name: Serine/threonine-protein kinase Chk1
List of molecules and drugs that interact with protein O14757
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O14757_07S | 07S | n/a | 56932125 | CHEMBL2011328 | 1-(morpholin-4-yl)-2-[4-(2-{[5-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperazin-1-yl]ethanone | n/a | |
| 2 | O14757_09H | 09H | n/a | 25095215 | CHEMBL2037017 | 2-(2,3-dihydro-1-benzofuran-5-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide | n/a | |
| 3 | O14757_12C | 12C | DB06852 | 135399748 | CHEMBL377312 | 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE | n/a | |
| 4 | O14757_199 | 199 | DB06876 | 6914568 | n/a | N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE | n/a | |
| 5 | O14757_1AM | 1AM | n/a | 24951610 | CHEMBL2381116 | 2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide | n/a | |
| 6 | O14757_1AO | 1AO | n/a | 59332218 | CHEMBL2381246 | 2-(1H-indazol-1-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide | n/a | |
| 7 | O14757_1HK | 1HK | n/a | 137347960 | n/a | 4-[2-(2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ethyl]-2-methoxyphenol | n/a | |
| 8 | O14757_1KO | 1KO | n/a | 72188683 | CHEMBL2381611 | 2-(4-chlorophenyl)-8-[(3S)-piperidin-3-ylamino]imidazo[1,2-c]pyrimidine-5-carboxamide | n/a | |
| 9 | O14757_22K | 22K | n/a | 49866432 | n/a | 5-[(1R,3S)-3-aminocyclohexyl]-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine | n/a | |
| 10 | O14757_2HK | 2HK | n/a | 60138172 | n/a | 4'-{6-methoxy-7-[2-(piperidin-1-yl)ethoxy]-1,2-dihydroindeno[1,2-c]pyrazol-3-yl}biphenyl-4-ol | n/a | |
| 11 | O14757_306 | 306 | n/a | 11690363 | CHEMBL374662 | 3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-6-(1H-PYRAZOL-4-YL)QUINOLIN-2(1H)-ONE | n/a | |
| 12 | O14757_373 | 373 | DB07025 | 10156987 | CHEMBL221735 | 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE | n/a | IC50(nM) = 140.0 |
| 13 | O14757_38M | 38M | n/a | 25134270 | n/a | 3-(3-chlorophenyl)-2-({(1S)-1-[(6S)-2,8-diazaspiro[5.5]undec-2-ylcarbonyl]pentyl}sulfanyl)quinazolin-4(3H)-one | n/a | |
| 14 | O14757_3A3 | 3A3 | DB07034 | 3506204 | n/a | 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID | n/a | |
| 15 | O14757_3B3 | 3B3 | DB07037 | 6540273 | n/a | (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL | n/a | IC50(nM) = 27300.0 |
| 16 | O14757_3C3 | 3C3 | n/a | 6857689 | n/a | 4,4'-(1-PROPYL-1H-1,2,4-TRIAZOLE-3,5-DIYL)BIS(2,5-DIHYDRO-1,2,5-OXADIAZOL-3-AMINE) | n/a | |
| 17 | O14757_3D3 | 3D3 | n/a | 1548380 | CHEMBL468815 | 2-[(6-AMINO-7H-PURIN-8-YL)THIO]ACETAMIDE | n/a | |
| 18 | O14757_3DL | 3DL | n/a | 86290236 | CHEMBL3359881 | 4-[6-(3-hydroxyphenyl)pyrazin-2-yl]benzoic acid | n/a | |
| 19 | O14757_3DV | 3DV | n/a | 86290237 | n/a | 4-[3-amino-6-(3-hydroxyphenyl)pyrazin-2-yl]benzoic acid | n/a | |
| 20 | O14757_3DW | 3DW | n/a | 58266559 | CHEMBL3359893 | 3-[4-(4-methylpiperazin-1-yl)phenyl]-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carboxylic acid | n/a | |
| 21 | O14757_3DX | 3DX | n/a | 44545901 | CHEMBL3359895 | 3-[4-(4-methylpiperazin-1-yl)phenyl]-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile | n/a | |
| 22 | O14757_3FE | 3FE | n/a | 72706840 | CHEMBL3393348 | 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | n/a | |
| 23 | O14757_3HK | 3HK | n/a | 44443191 | CHEMBL400689 | 4-{7-methoxy-6-[3-(morpholin-4-yl)propoxy]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl}benzonitrile | n/a | |
| 24 | O14757_3X7 | 3X7 | n/a | 44545757 | CHEMBL3582201 | 3-[4-(piperidin-1-ylmethyl)phenyl]-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile | n/a | |
| 25 | O14757_3XK | 3XK | n/a | 68346820 | CHEMBL3582190 | N-[3-(6-cyano-9H-pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide | n/a | |
| 26 | O14757_3XL | 3XL | n/a | 44546231 | CHEMBL3582189 | 3-(2-hydroxyphenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile | n/a | |
| 27 | O14757_422 | 422 | DB07075 | 135525556 | CHEMBL221181 | 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE | n/a | IC50(nM) = 12.0 |
| 28 | O14757_42C | 42C | n/a | 3134 | CHEMBL407391 | N,N-dimethyl-7H-purin-6-amine | n/a | |
| 29 | O14757_43A | 43A | DB07078 | 10125830 | CHEMBL202930 | (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE | inhibitor | Ki(nM) = 32.0 IC50(nM) = 7.0 |
| 30 | O14757_4HK | 4HK | n/a | 60138173 | n/a | 5-{7-ethyl-6-[(3S)-tetrahydrofuran-3-yloxy]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl}pyridine-2-carbonitrile | n/a | |
| 31 | O14757_4K4 | 4K4 | n/a | 46843906 | CHEMBL2012582 | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | n/a | |
| 32 | O14757_4UB | 4UB | n/a | 49797838 | CHEMBL1172464 | 3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE | n/a | |
| 33 | O14757_4YM | 4YM | n/a | 54759151 | n/a | ethyl 4-[(2R)-2-(aminomethyl)morpholin-4-yl]-3-(3-cyanophenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | n/a | |
| 34 | O14757_582 | 582 | DB07158 | 708346 | n/a | 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE | n/a | |
| 35 | O14757_5BE | 5BE | n/a | 135566521 | n/a | 3-methyl-5-[5-(1-methylethyl)-1H-benzimidazol-2-yl]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide | n/a | |
| 36 | O14757_5CV | 5CV | n/a | 44198296 | n/a | 1-benzyl-N-(5-{5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1H-indol-2-yl}-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide | n/a | |
| 37 | O14757_5HK | 5HK | n/a | 10003686 | CHEMBL562875 | 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]-N,N-dimethylacetamide | n/a | |
| 38 | O14757_5UY | 5UY | n/a | 86338721 | n/a | methyl 6-[(5-cyanopyrazin-2-yl)amino]-4-[[(2~{R})-morpholin-2-yl]methylamino]pyridine-3-carboxylate | n/a | |
| 39 | O14757_6HK | 6HK | n/a | 45271183 | CHEMBL550073 | methyl [3-(1-methyl-1H-imidazol-5-yl)-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]acetate | n/a | |
| 40 | O14757_710 | 710 | DB07213 | 135414460 | CHEMBL374713 | (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL | n/a | |
| 41 | O14757_76A | 76A | n/a | n/a | CHEMBL438485 | 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE | n/a | |
| 42 | O14757_77A | 77A | DB07228 | 23657800 | n/a | 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA | n/a | |
| 43 | O14757_7CS | 7CS | DB07243 | n/a | n/a | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE | n/a | |
| 44 | O14757_7HK | 7HK | n/a | 45270361 | CHEMBL564542 | methyl [11-oxo-3-(pyridin-4-ylamino)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl]acetate | n/a | |
| 45 | O14757_85A | 85A | n/a | 11329100 | CHEMBL220035 | 18-CHLORO-2-OXO-17-[(PYRIDIN-4-YLMETHYL)AMINO]-2,3,11,12,13,14-HEXAHYDRO-1H,10H-4,8-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECINE-7-CARBONITRILE | n/a | |
| 46 | O14757_A0Q | A0Q | n/a | 51357515 | CHEMBL3604124 | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{N}-pyridin-3-yl-benzamide | n/a | |
| 47 | O14757_A0T | A0T | n/a | 58539171 | CHEMBL2178134 | [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone | n/a | |
| 48 | O14757_A1K | A1K | n/a | 112499966 | CHEMBL4540808 | [4-[[5-chloranyl-4-(methylamino)-7~{H}-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-phenyl]-morpholin-4-yl-methanone | n/a | |
| 49 | O14757_A1N | A1N | n/a | 78319901 | CHEMBL4098877 | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine | n/a | |
| 50 | O14757_A25 | A25 | DB07311 | 11348631 | CHEMBL223512 | 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE | n/a | Ki(nM) = 7.9 IC50(nM) = 10.0 |
| 51 | O14757_A3E | A3E | n/a | 77106759 | CHEMBL3971067 | 5-[4-(morpholin-4-ylmethyl)phenyl]-3-(1-propan-2-yl-1,2,3-triazol-4-yl)pyridin-2-amine | n/a | |
| 52 | O14757_A3H | A3H | n/a | 86275848 | CHEMBL3969077 | 4-(3-methylphenyl)-6-[(1-methylpyrazol-3-yl)amino]-1~{H}-pyrrolo[2,3-b]pyridine-3-carbonitrile | n/a | |
| 53 | O14757_A3K | A3K | n/a | 86287744 | CHEMBL3961632 | 6-azanyl-4-(3-methylphenyl)-1~{H}-pyrrolo[2,3-b]pyridine-3-carbonitrile | n/a | |
| 54 | O14757_A3Q | A3Q | n/a | 24772735 | CHEMBL4068861 | 4-(3-hydroxyphenyl)-1~{H}-pyrrolo[2,3-b]pyridine-3-carbonitrile | n/a | |
| 55 | O14757_A42 | A42 | DB07314 | 16122643 | CHEMBL207994 | 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA | n/a | Ki(nM) = 10.0 IC50(nM) = 7.0 |
| 56 | O14757_A53 | A53 | n/a | 10310919 | CHEMBL1230726 | 5-{5-[(S)-2-AMINO-3-(1H-INDOL-3-YL)-PROPOXYL]-PYRIDIN-3-YL}-3-[1-(1H-PYRROL-2-YL)-METH-(Z)-YLIDENE]-1,3-DIHYDRO-INDOL-2-ONE | n/a | |
| 57 | O14757_A58 | A58 | DB07320 | n/a | CHEMBL242737 | 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID | n/a | Ki(nM) = 20.0 IC50(nM) = 22.0 |
| 58 | O14757_ABO | ABO | DB07336 | 135446004 | n/a | 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL | n/a | Ki(nM) = 26.0 IC50(nM) = 42.0 |
| 59 | O14757_ADE | ADE | DB00173 | 190 | CHEMBL226345 | ADENINE | n/a | |
| 60 | O14757_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 61 | O14757_AGX | AGX | n/a | 44183922 | n/a | (1S)-1-(1H-benzimidazol-2-yl)ethyl (3,4-dichlorophenyl)carbamate | n/a | |
| 62 | O14757_AGY | AGY | n/a | 44224009 | CHEMBL1230881 | 2-[(4-tert-butyl-3-nitrophenyl)carbonyl]-N-naphthalen-1-ylhydrazinecarboxamide | n/a | |
| 63 | O14757_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 64 | O14757_BVI | BVI | n/a | 162394494 | CHEMBL5089933 | 8-cyclopropyl-N-[5-methyl-1-(oxan-4-yl)-1H-pyrazol-4-yl]quinazolin-2-amine | n/a | |
| 65 | O14757_BWI | BWI | n/a | 162394529 | n/a | 1-(2-{[5-methyl-1-(oxan-4-yl)-1H-pyrazol-4-yl]amino}quinazolin-8-yl)cyclopropane-1-carbonitrile | n/a | |
| 66 | O14757_BXI | BXI | n/a | 156297280 | CHEMBL5073571 | 1-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol | n/a | |
| 67 | O14757_BYL | BYL | n/a | 162394496 | n/a | (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol | n/a | |
| 68 | O14757_C70 | C70 | n/a | 49786973 | CHEMBL1231624 | 2-(4-chlorophenyl)-4-[(3S)-piperidin-3-ylamino]thieno[2,3-d]pyridazine-7-carboxamide | n/a | |
| 69 | O14757_C72 | C72 | n/a | 44133237 | CHEMBL1231626 | 2-(4-chlorophenyl)-4-[(3S)-piperidin-3-ylamino]thieno[3,2-c]pyridine-7-carboxamide | n/a | |
| 70 | O14757_C73 | C73 | n/a | 11451776 | CHEMBL470288 | 2-(carbamoylamino)-5-(4-chlorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide | n/a | |
| 71 | O14757_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 72 | O14757_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 73 | O14757_D4Q | D4Q | n/a | 11951723 | CHEMBL4098878 | 2-(3-fluorophenyl)-4-[[(3~{S})-piperidin-3-yl]amino]thieno[3,2-c]pyridine-7-carboxamide | n/a | |
| 74 | O14757_D4Z | D4Z | n/a | 11952264 | CHEMBL4096683 | 2-phenyl-4-[[(3~{S})-piperidin-3-yl]amino]-1~{H}-indole-7-carboxamide | n/a | |
| 75 | O14757_D58 | D58 | n/a | 11951901 | CHEMBL4059912 | 4-[[(2~{R},3~{S})-2-methylpiperidin-3-yl]amino]-2-phenyl-thieno[3,2-c]pyridine-7-carboxamide | n/a | |
| 76 | O14757_DBQ | DBQ | DB04367 | 5288032;135451156; | CHEMBL255465 | DEBROMOHYMENIALDISINE | inhibitor | |
| 77 | O14757_DF1 | DF1 | DB07647 | 4369434 | n/a | (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL | n/a | |
| 78 | O14757_DF2 | DF2 | DB07648 | 4369435 | n/a | (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL | n/a | |
| 79 | O14757_DFW | DFW | DB07653 | 848641;30281577; | CHEMBL363302 | N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE | inhibitor | IC50(nM) = 22900.0 |
| 80 | O14757_DFY | DFY | DB07654 | 4369432 | CHEMBL364811 | (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC | n/a | IC50(nM) = 6100.0 |
| 81 | O14757_DFZ | DFZ | DB07655 | 4369433 | CHEMBL366312 | 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE | n/a | IC50(nM) = 2300.0 |
| 82 | O14757_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 83 | O14757_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 84 | O14757_H0K | H0K | n/a | 135566734 | CHEMBL232804 | 4'-[7-(hydroxymethyl)-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]biphenyl-4-ol | n/a | |
| 85 | O14757_H1K | H1K | n/a | 18449135 | CHEMBL549867 | 1-(5-chloro-2,4-dimethoxyphenyl)-3-pyrazin-2-ylurea | n/a | |
| 86 | O14757_H2K | H2K | n/a | 60138166 | n/a | 1-{5-chloro-2-[(3R)-pyrrolidin-3-yloxy]phenyl}-3-(5-cyanopyrazin-2-yl)urea | n/a | |
| 87 | O14757_H3K | H3K | n/a | 60138167 | n/a | 1-{5-bromo-2-[(3R)-3-hydroxypiperidin-1-yl]phenyl}-3-(5-cyanopyrazin-2-yl)urea | n/a | |
| 88 | O14757_H4K | H4K | n/a | 45266971 | CHEMBL540497 | 1-(5-cyanopyrazin-2-yl)-3-isoquinolin-3-ylurea | n/a | |
| 89 | O14757_H5K | H5K | n/a | 45269554 | CHEMBL560813 | 6-{[(5-cyanopyrazin-2-yl)carbamoyl]amino}naphthalene-2-carboxylic acid | n/a | |
| 90 | O14757_H6K | H6K | n/a | 60138168 | n/a | 1-(5-cyanopyrazin-2-yl)-3-(5-phenyl-1H-pyrazol-3-yl)urea | n/a | |
| 91 | O14757_H7K | H7K | n/a | n/a | n/a | methyl 5-(6-{[(cis-4-hydroxycyclohexyl)amino]methyl}-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)furan-2-carboxylate | n/a | |
| 92 | O14757_H8K | H8K | n/a | n/a | n/a | trans-4-({[3-(furan-3-yl)-2,4-dihydroindeno[1,2-c]pyrazol-6-yl]methyl}amino)cyclohexanol | n/a | |
| 93 | O14757_H9K | H9K | n/a | 135464186 | CHEMBL391449 | 3-(4'-hydroxybiphenyl-4-yl)-2,4-dihydroindeno[1,2-c]pyrazol-6-ol | n/a | |
| 94 | O14757_HK0 | HK0 | n/a | 60196239 | n/a | 3-(3-methoxy-4-nitrophenyl)-6-[2-(morpholin-4-yl)ethoxy]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | n/a | |
| 95 | O14757_HK1 | HK1 | n/a | 135566732 | CHEMBL401274 | 4-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenol | n/a | |
| 96 | O14757_HK3 | HK3 | n/a | 137349516 | n/a | 4'-(6,7-dimethoxyindeno[1,2-c]pyrazol-3-yl)biphenyl-4-ol | n/a | |
| 97 | O14757_HK4 | HK4 | n/a | 44443175 | CHEMBL248396 | 4-[(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ethynyl]-2-methoxyphenol | n/a | |
| 98 | O14757_HK5 | HK5 | n/a | 23661658 | CHEMBL247396 | 4-[6-(1H-imidazol-1-ylmethyl)-7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzonitrile | n/a | |
| 99 | O14757_HK6 | HK6 | n/a | 3653116 | CHEMBL396034 | 8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | n/a | |
| 100 | O14757_HK7 | HK7 | n/a | 45268686 | CHEMBL563187 | 2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)benzamide | n/a | |
| 101 | O14757_HK8 | HK8 | n/a | 60138165 | n/a | (3-chloro-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-8-yl)acetic acid | n/a | |
| 102 | O14757_HK9 | HK9 | n/a | 10406209 | CHEMBL552355 | 2-methoxy-4-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-yl)benzoic acid | n/a | |
| 103 | O14757_HKC | HKC | n/a | 44443166 | CHEMBL245605 | 6,7-dimethoxy-3-[4-(1H-tetrazol-5-yl)phenyl]-1,4-dihydroindeno[1,2-c]pyrazole | n/a | |
| 104 | O14757_HYM | HYM | n/a | 11840954;135431468; | CHEMBL1233473 | (4Z)-4-(2-AMINO-5-OXO-3,5-DIHYDRO-4H-IMIDAZOL-4-YLIDENE)-2,3-DICHLORO-4,5,6,7-TETRAHYDROPYRROLO[2,3-C]AZEPIN-8(1H)-ONE | n/a | |
| 105 | O14757_IDZ | IDZ | DB07959 | 135464491 | CHEMBL383990 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE | n/a | Ki(nM) = 8580.0 IC50(nM) = 6296.0 |
| 106 | O14757_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | n/a | |
| 107 | O14757_L80 | L80 | n/a | 162394495 | CHEMBL5076397 | (3R,4R)-4-{(3S,4S)-4-[6-chloro-2-({5-chloro-1-[(1R)-2,2-difluorocyclopropyl]-1H-pyrazol-4-yl}amino)quinazolin-7-yl]-3-fluoropiperidin-1-yl}oxolan-3-ol | n/a | |
| 108 | O14757_M54 | M54 | n/a | 16758227 | CHEMBL249441 | 6-(3-aminopropyl)-4-(3-hydroxyphenyl)-9-(1H-pyrazol-4-yl)benzo[h]isoquinolin-1(2H)-one | n/a | |
| 109 | O14757_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 110 | O14757_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 111 | O14757_MI5 | MI5 | n/a | 49867310 | n/a | N-(3-methylisothiazol-5-yl)-3-(1-methyl-1H-pyrazol-4-yl)-5-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine | n/a | |
| 112 | O14757_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 113 | O14757_PFP | PFP | DB08392 | 2059510 | CHEMBL190201 | 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL | n/a | IC50(nM) = 15400.0 |
| 114 | O14757_PFQ | PFQ | DB08393 | 1587957 | CHEMBL189434 | 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL | n/a | IC50(nM) = 20900.0 |
| 115 | O14757_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 116 | O14757_S25 | S25 | n/a | 15980109 | CHEMBL2010809 | N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide | n/a | |
| 117 | O14757_SO3 | SO3 | n/a | 1099 | n/a | SULFITE ION | n/a | |
| 118 | O14757_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 119 | O14757_TQ1 | TQ1 | n/a | 57345538 | CHEMBL2012881 | 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE | n/a | |
| 120 | O14757_TVT | TVT | n/a | 69093374 | CHEMBL3122113 | 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile | n/a | |
| 121 | O14757_TVW | TVW | n/a | 75420 | CHEMBL388593 | 1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 122 | O14757_TW2 | TW2 | n/a | 155928382 | CHEMBL5093047 | 4-amino-6-{[(2-fluorophenyl)methyl]amino}-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 123 | O14757_TWH | TWH | n/a | 155928384 | CHEMBL5086513 | 4-amino-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 124 | O14757_TWK | TWK | n/a | 155928383 | CHEMBL5093192 | 4-amino-6-(2,3-difluorophenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 125 | O14757_U0K | U0K | n/a | 155928387 | CHEMBL5087055 | 4-amino-7-methyl-2-({5-methyl-1-[(3R)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 126 | O14757_U0N | U0N | n/a | 155928386 | CHEMBL5083563 | 4-amino-2-[(1,3-dimethyl-1H-pyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 127 | O14757_U0Q | U0Q | n/a | 155928385 | CHEMBL5075978 | 4-amino-7-methyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 128 | O14757_U0T | U0T | n/a | 155928388 | CHEMBL5092087 | 4-amino-7-methyl-2-({5-methyl-1-[(3S)-oxolan-3-yl]-1H-pyrazol-4-yl}amino)-6-[(2R)-2-methylpyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 129 | O14757_UCM | UCM | DB08683 | 447446 | CHEMBL289422 | REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE | inhibitor | |
| 130 | O14757_UCN | UCN | DB01933 | 72271 | CHEMBL1236539 | 7-HYDROXYSTAUROSPORINE | inhibitor | |
| 131 | O14757_UU6 | UU6 | n/a | 156493868 | n/a | (1S)-1-[(1P)-1-{6-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl}-1H-indazol-6-yl]spiro[2.2]pentane-1-carbonitrile | n/a | |
| 132 | O14757_UUF | UUF | n/a | n/a | n/a | 2-[(1r,4r)-2-{(6P)-6-[(6M)-6-(1H-pyrazol-5-yl)-1H-indazol-1-yl]pyrimidin-4-yl}-2-azabicyclo[2.1.1]hexan-4-yl]propan-2-ol | n/a | |
| 133 | O14757_X8D | X8D | n/a | 9815578 | CHEMBL487274 | 5-METHYL[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE | n/a | |
| 134 | O14757_X8E | X8E | n/a | 10333656 | CHEMBL1223458 | 5-METHYL-8-PYRIDIN-4-YL[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE | n/a | |
| 135 | O14757_X8I | X8I | n/a | 49867837 | n/a | 7-(3-hydroxyphenyl)-5-methyl[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one | n/a | |
| 136 | O14757_XEZ | XEZ | n/a | 46911673 | CHEMBL1236804 | 6-(1H-PYRAZOL-3-YL)-3-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE | n/a | |
| 137 | O14757_YDI | YDI | n/a | 9902908 | CHEMBL452021 | 5-[4-(2-DIMETHYLAMINOETHYLOXY)PHENYL]-2-UREIDO-THIOPHENE-3-CARBOXAMIDE | n/a | |
| 138 | O14757_YDJ | YDJ | DB12242 | 11152667 | CHEMBL2041933 | 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | inhibitor | |
| 139 | O14757_YDK | YDK | n/a | 11313946 | CHEMBL487273 | 2-(CARBAMOYLAMINO)-5-PHENYL-N-[(3S)-PIPERIDIN-3-YL]THIOPHENE-3-CARBOXAMIDE | n/a | |
| 140 | O14757_YEX | YEX | n/a | 46934729 | CHEMBL1223526 | 5-METHYL-8-(1H-PYRROL-2-YL)[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE | n/a | |
| 141 | O14757_YM3 | YM3 | n/a | 54759150 | n/a | ETHYL 4-(2-(AMINOMETHYL)MORPHOLINO)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE | n/a | |
| 142 | O14757_YM5 | YM5 | n/a | 54759152 | n/a | (3-{4-[(2S)-2-(AMINOMETHYL)MORPHOLIN-4-YL]-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL}PHENYL)METHANOL | n/a | |
| 143 | O14757_YM6 | YM6 | n/a | 25222086 | n/a | 1-[(2R)-4-(9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-4-yl)morpholin-2-yl]methanamine | n/a | |
| 144 | O14757_YM7 | YM7 | n/a | 42610483 | CHEMBL1928689 | 5-({6-[(piperidin-4-ylmethyl)amino]pyrimidin-4-yl}amino)pyrazine-2-carbonitrile | n/a | |
| 145 | O14757_YM8 | YM8 | n/a | 44203948 | CHEMBL1928705 | (R)-5-(8-CHLOROISOQUINOLIN-3-YLAMINO)-3-(1-(DIMETHYLAMINO)PROPAN-2-YLOXY)PYRAZINE-2-CARBONITRILE | n/a | |
| 146 | O14757_YVQ | YVQ | n/a | 136016456 | CHEMBL1170126 | 3-(1H-INDOL-3-YL)-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE | n/a | |
| 147 | O14757_YXD | YXD | n/a | 155923505 | n/a | N-{5-[(3S)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)pyridine-2-carboxamide | n/a | |
| 148 | O14757_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 149 | O14757_ZXH | ZXH | n/a | 168719780 | CHEMBL5407732 | N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)cyclopropanecarboxamide | n/a | |
| 150 | O14757_ZXL | ZXL | n/a | 168719781 | CHEMBL5419587 | (1S,2S)-N-(7-chloro-6-{1-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperidin-4-yl}isoquinolin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)cyclopropane-1-carboxamide | n/a | |
| 151 | O14757_ZXP | ZXP | n/a | 163277830 | CHEMBL5408287 | (1S)-N-(7-chloro-6-{4-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperazin-1-yl}isoquinolin-3-yl)-6-oxaspiro[2.5]octane-1-carboxamide | n/a | |
| 152 | O14757_ZY6 | ZY6 | DB08774 | 44129608 | CHEMBL562314 | 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine | n/a | IC50(nM) = 860.0 |
| 153 | O14757_ZYQ | ZYQ | DB08776 | 739358 | CHEMBL562743 | N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE | n/a | |
| 154 | O14757_ZYR | ZYR | DB08777 | 98614;5285009; | CHEMBL539906 | 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE | n/a | IC50(nM) = 52000.0 |
| 155 | O14757_ZYS | ZYS | DB08778 | 1484819 | CHEMBL570537 | [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone | n/a | |
| 156 | O14757_ZYT | ZYT | DB08779 | 46937179 | n/a | 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol | n/a | |
| 157 | O14757_ZYU | ZYU | DB08780 | 76098 | CHEMBL271138 | 6-MORPHOLIN-4-YL-9H-PURINE | inhibitor | |
| 158 | O14757_ZYV | ZYV | n/a | 44129607 | n/a | 1-[(2S)-4-(7H-PURIN-6-YL)MORPHOLIN-2-YL]METHANAMINE | n/a | |
| 159 | O14757_ZYW | ZYW | DB08781 | 44141939 | n/a | 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE | n/a | |
| 160 | O14757_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | Ki(nM) = 7.9 |
| 161 | O14757_DB06486 | n/a | DB06486 | n/a | n/a | Enzastaurin | n/a | |
| 162 | O14757_3B4 | 3B4 | DB07038 | 19826721 | n/a | 2-(cyclohexylamino)benzoic acid | inhibitor | |
| 163 | O14757_DB12008 | n/a | DB12008 | n/a | n/a | Prexasertib | inhibitor | |
| 164 | O14757_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 165 | O14757_DB12284 | n/a | DB12284 | n/a | n/a | LY-2608204 | inhibitor | |
| 166 | O14757_9DB | 9DB | DB12611 | 135565545 | CHEMBL3990456 | PF-477736 | inhibitor |