Gene name: PDPK1
Protein name: 3-phosphoinositide-dependent protein kinase
List of molecules and drugs that interact with protein O15530
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O15530_1F8 | 1F8 | n/a | 50937461 | n/a | 2-methyl-N-(2-sulfanylethyl)-1-benzofuran-3-carboxamide | n/a | |
| 2 | O15530_21O | 21O | n/a | 60196221 | CHEMBL2177665 | {(1R)-3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl}propanedioic acid | n/a | |
| 3 | O15530_253 | 253 | DB06932 | 17754396 | CHEMBL235157 | 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine | n/a | IC50(nM) = 60.0 |
| 4 | O15530_2A2 | 2A2 | n/a | 50937462 | n/a | 4-[4-(3-chlorophenyl)piperazin-1-yl]-4-oxobutane-1-thiol | n/a | |
| 5 | O15530_31S | 31S | n/a | 45381796 | n/a | (2Z)-3-(biphenyl-4-yl)-5-(4-chlorophenyl)pent-2-enoic acid | n/a | |
| 6 | O15530_39Z | 39Z | DB07033 | 46937045 | n/a | 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE | n/a | |
| 7 | O15530_3Q0 | 3Q0 | n/a | 46214652 | CHEMBL1614771 | 6-(3-amino-2H-indazol-6-yl)-N~4~-ethylpyrimidine-2,4-diamine | n/a | |
| 8 | O15530_3Q1 | 3Q1 | n/a | 46214653 | CHEMBL1614772 | 6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2H-indazol-3-amine | n/a | |
| 9 | O15530_3Q2 | 3Q2 | n/a | 46215988 | CHEMBL1614773 | 6-{2-amino-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl}-2H-indazol-3-amine | n/a | |
| 10 | O15530_3Q3 | 3Q3 | n/a | 50909914 | CHEMBL1614774 | (2S)-4-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-N-phenylmorpholine-2-carboxamide | n/a | |
| 11 | O15530_3Q4 | 3Q4 | n/a | 50909915 | CHEMBL1614775 | (3S,6R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide | n/a | |
| 12 | O15530_3Q5 | 3Q5 | n/a | 50909916 | CHEMBL1614776 | tert-butyl {(3R,6S)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-6-methylpiperidin-3-yl}carbamate | n/a | |
| 13 | O15530_3Q6 | 3Q6 | n/a | 50909917 | CHEMBL1614777 | tert-butyl {(3R,5R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl}carbamate | n/a | |
| 14 | O15530_3RC | 3RC | n/a | 49784217 | n/a | 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | n/a | |
| 15 | O15530_3RW | 3RW | n/a | 53488414 | CHEMBL1940244 | [4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl](6-{[2-(pyridin-3-yl)ethyl]amino}pyrazin-2-yl)methanone | n/a | |
| 16 | O15530_3S1 | 3S1 | n/a | 53393807 | n/a | 6-[2-(hydroxymethyl)phenyl]isoquinolin-1(2H)-one | n/a | |
| 17 | O15530_464 | 464 | n/a | 16129585 | n/a | 3-[5-({5-[(AMINOCARBONYL)AMINO]-2-OXO-2H-INDOL-3-YL}METHYL)-1H-PYRROL-3-YL]-N-(2-PIPERIDIN-1-YLETHYL)BENZAMIDE | n/a | |
| 18 | O15530_4IP | 4IP | DB01863 | n/a | CHEMBL23552 | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | n/a | |
| 19 | O15530_4PT | 4PT | n/a | n/a | n/a | (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE | n/a | |
| 20 | O15530_517 | 517 | DB07132 | 46937053 | n/a | 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA | n/a | |
| 21 | O15530_537 | 537 | DB01782 | 8515 | CHEMBL7064 | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE | n/a | |
| 22 | O15530_61Y | 61Y | n/a | 25165773 | CHEMBL3813865 | 4-ethyl-6-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine | n/a | |
| 23 | O15530_62O | 62O | n/a | 135567140 | CHEMBL3815097 | 6-methoxy-2-(1H-pyrazol-5-yl)-1H-benzimidazole | n/a | |
| 24 | O15530_63E | 63E | n/a | 25110819 | CHEMBL3814340 | 4-butyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine | n/a | |
| 25 | O15530_63L | 63L | n/a | 119081690 | CHEMBL3814512 | 5-amino-3-(methylsulfanyl)-1H-pyrazole-1,4-dicarboxamide | n/a | |
| 26 | O15530_78W | 78W | n/a | 2726483;5836033;135472998; | n/a | 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate | n/a | |
| 27 | O15530_8H1 | 8H1 | n/a | 44608012 | CHEMBL1097602 | 2-(5-{[(2S)-2-amino-3-phenylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine | n/a | |
| 28 | O15530_8I1 | 8I1 | n/a | 44620952 | CHEMBL1095294 | 2-(5-{[(2R)-2-amino-3-phenylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine | n/a | |
| 29 | O15530_9BD | 9BD | DB07300 | 44176356 | CHEMBL571159 | 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine | n/a | IC50(nM) = 70.0 |
| 30 | O15530_A06 | A06 | n/a | 45380882 | CHEMBL1829819 | (3S)-4-(5-chloro-1H-benzimidazol-2-yl)-3-(4-chlorophenyl)butanoic acid | n/a | |
| 31 | O15530_ABQ | ABQ | n/a | 45139233 | CHEMBL1938415 | [4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl](6-{[(3S,4R)-4-(4-fluorophenyl)tetrahydrofuran-3-yl]amino}pyrazin-2-yl)methanone | n/a | |
| 32 | O15530_ADE | ADE | DB00173 | 190 | CHEMBL226345 | ADENINE | n/a | |
| 33 | O15530_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | n/a | |
| 34 | O15530_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 35 | O15530_AU | AU | n/a | 114945 | n/a | GOLD ION | n/a | |
| 36 | O15530_AZ7 | AZ7 | n/a | 137348961 | n/a | (3S)-3-(4-CHLOROPHENYL)-4-(5,7-DICHLORO-1H-BENZIMIDAZOL-2-YL)BUTANOIC ACID | n/a | |
| 37 | O15530_BI1 | BI1 | DB03777 | 2396 | CHEMBL7463 | 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | n/a | IC50(nM) = 9000.0 |
| 38 | O15530_BI2 | BI2 | DB07456 | 448943 | n/a | 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | n/a | |
| 39 | O15530_BI3 | BI3 | DB07457 | 2398 | CHEMBL270875 | 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | n/a | IC50(nM) = 2000.0 |
| 40 | O15530_BI4 | BI4 | DB07458 | 448642 | n/a | 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE | n/a | |
| 41 | O15530_BI8 | BI8 | DB01946 | 2403 | CHEMBL269264 | 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | n/a | IC50(nM) = 1000.0 |
| 42 | O15530_CKG | CKG | n/a | 49866796 | n/a | 8-(CYCLOHEXA-2,5-DIEN-1-YLIDENEAMINO)-1-(PIPERIDIN-4-YLMETHYL)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | n/a | |
| 43 | O15530_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 44 | O15530_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 45 | O15530_DTD | DTD | DB01822 | 439407 | n/a | DITHIANE DIOL | n/a | |
| 46 | O15530_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 47 | O15530_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 48 | O15530_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 49 | O15530_J30 | J30 | n/a | 50937463 | n/a | 4-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-4-oxobutane-1-thiol | n/a | |
| 50 | O15530_LI8 | LI8 | n/a | 657138 | CHEMBL573108 | N-(3-{[5-BROMO-2-({3-[(PYRROLIDIN-1-YLCARBONYL)AMINO]PHENYL}AMINO)PYRIMIDIN-4-YL]AMINO}PROPYL)-2,2-DIMETHYLMALONAMIDE | n/a | |
| 51 | O15530_LY4 | LY4 | DB11829 | 153999 | CHEMBL91829 | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE | n/a | |
| 52 | O15530_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 53 | O15530_MH4 | MH4 | n/a | 46829290 | CHEMBL1169805 | 1-METHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-N-[(2-METHYLPYRIDIN-4-YL)METHYL]-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | n/a | |
| 54 | O15530_MJF | MJF | n/a | 60196220 | n/a | [(1R)-3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]propanedioic acid | n/a | |
| 55 | O15530_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 56 | O15530_MP6 | MP6 | n/a | 49867326 | n/a | 4-(2-cyclopropylethylidene)-9-(1H-pyrazol-4-yl)-6-{[(1R)-1,2,2-trimethylpropyl]amino}benzo[c][1,6]naphthyridin-1(4H)-one | n/a | |
| 57 | O15530_MP7 | MP7 | n/a | 49766501 | CHEMBL1234429 | 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide | n/a | |
| 58 | O15530_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 59 | O15530_P47 | P47 | n/a | 44141940 | CHEMBL539134 | (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid | n/a | |
| 60 | O15530_R1S | R1S | n/a | 86290241 | CHEMBL4592040 | N-(6-chloro-1,3-benzothiazol-2-yl)-1-benzothiophene-3-sulfonamide | n/a | |
| 61 | O15530_R2S | R2S | n/a | 86290242 | n/a | N-(6-chloro-1,3-benzothiazol-2-yl)-1-benzothiophene-2-sulfonamide | n/a | |
| 62 | O15530_RF4 | RF4 | n/a | 1718009;2849295; | CHEMBL1439113 | (2-{[2-(2,6-dimethylphenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid | n/a | |
| 63 | O15530_S26 | S26 | n/a | 137349978 | n/a | ethyl (2~{S})-1-(6-chloranyl-1,3-benzothiazol-2-yl)-4-oxidanyl-5-oxidanylidene-2-thiophen-2-yl-2~{H}-pyrrole-3-carboxylate | n/a | |
| 64 | O15530_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 65 | O15530_U35 | U35 | DB00177 | 60846 | CHEMBL1069 | (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid | n/a | |
| 66 | O15530_UCN | UCN | DB01933 | 72271 | CHEMBL1236539 | 7-HYDROXYSTAUROSPORINE | n/a | |
| 67 | O15530_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 68 | O15530_SVQ | SVQ | n/a | 91971262 | n/a | 1-(4-CHLOROPHENETHYL)-2-(2-CHLOROPHENYL)-6-OXOPIPERIDINE-3-CARBOXYLIC ACID | n/a | |
| 69 | O15530_SYP | SYP | n/a | 53321607 | n/a | N-[2-({6-[(2-sulfanylethyl)amino]pyrimidin-4-yl}amino)ethyl]propanamide | n/a | |
| 70 | O15530_CEL | CEL | DB00482 | 2662 | CHEMBL118 | Celecoxib | inhibitor | IC50(nM) = 48000.0 |
| 71 | O15530_SEP | SEP | DB04522 | 68841;57689797; | CHEMBL284377 | Dexfosfoserine | inhibitor | |
| 72 | O15530_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |