Gene name: HCRTR1
Protein name: Orexin/Hypocretin receptor type
List of molecules and drugs that interact with protein O43613
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O43613_4OT | 4OT | n/a | 10204153 | CHEMBL2110363 | [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone | n/a | |
| 2 | O43613_7MA | 7MA | n/a | 9981404 | CHEMBL2385132 | N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide | n/a | |
| 3 | O43613_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 4 | O43613_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 5 | O43613_CLR | CLR | DB04540 | 5997 | CHEMBL112570 | CHOLESTEROL | n/a | |
| 6 | O43613_JHC | JHC | n/a | 146675152 | n/a | [(2S)-2-[(2S)-butan-2-yl]-4-(5-chloro-1,3-benzoxazol-2-yl)-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone | n/a | |
| 7 | O43613_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 8 | O43613_NRE | NRE | n/a | 44463491 | CHEMBL2413522 | [(2~{S},5~{S})-2-[[(5-bromanylpyridin-2-yl)amino]methyl]-5-methyl-piperidin-1-yl]-(3-fluoranyl-2-methoxy-phenyl)methanone | n/a | |
| 9 | O43613_NRK | NRK | DB11951 | 56944144 | CHEMBL3545367 | (1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide | antagonist | |
| 10 | O43613_NRZ | NRZ | n/a | 40924317 | CHEMBL3597952 | (2~{S})-~{N}-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonyl-pyrrolidine-2-carboxamide | n/a | |
| 11 | O43613_NS2 | NS2 | DB15031 | 91801202 | CHEMBL4297590 | [(2~{S})-2-(6-chloranyl-7-methyl-1~{H}-benzimidazol-2-yl)-2-methyl-pyrrolidin-1-yl]-[5-methoxy-2-(1,2,3-triazol-2-yl)phenyl]methanone | antagonist | |
| 12 | O43613_NT5 | NT5 | DB12158 | 25128145 | CHEMBL2107822 | [(2~{R},5~{R})-5-[(5-fluoranylpyridin-2-yl)oxymethyl]-2-methyl-piperidin-1-yl]-(5-methyl-2-pyrimidin-2-yl-phenyl)methanone | n/a | |
| 13 | O43613_NV8 | NV8 | n/a | 16046844 | CHEMBL4590386 | 2-[1-(phenylsulfonyl)-1,8-diazaspiro[4.5]decan-8-yl]-1,3-benzoxazole | n/a | |
| 14 | O43613_NVH | NVH | n/a | n/a | CHEMBL4592653 | 2-(5-methylsulfonylpyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-e][1,2,4]thiadiazin-3-one | n/a | |
| 15 | O43613_NVK | NVK | n/a | 6604926 | CHEMBL291536 | 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea | n/a | |
| 16 | O43613_NVN | NVN | n/a | 4331799 | CHEMBL1334465 | 1-[6,8-bis(fluoranyl)-2-methyl-quinolin-4-yl]-3-[4-(dimethylamino)phenyl]urea | n/a | |
| 17 | O43613_OLA | OLA | n/a | 445639 | CHEMBL8659 | OLEIC ACID | n/a | |
| 18 | O43613_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 19 | O43613_PGW | PGW | n/a | 52941750 | n/a | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate | n/a | |
| 20 | O43613_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 21 | O43613_SOG | SOG | DB08558 | 656909 | n/a | octyl 1-thio-beta-D-glucopyranoside | n/a | |
| 22 | O43613_SUV | SUV | DB09034 | 24965990 | CHEMBL1083659 | [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone | antagonist | Ki(nM) = 0.398107 IC50(nM) = 50.0 |