Gene name: KDM1A
Protein name: Lysine-specific histone demethylase
List of molecules and drugs that interact with protein O60341
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O60341_12F | 12F | n/a | 46224505 | n/a | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3R,3aS)-3-[2-(benzyloxy)-3-fluorophenyl]-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate | n/a | |
| 2 | O60341_2PF | 2PF | n/a | 46224504 | n/a | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-(pentafluorophenyl)-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate | n/a | |
| 3 | O60341_3PL | 3PL | n/a | 7707 | CHEMBL440161 | 3-PHENYLPROPANAL | n/a | |
| 4 | O60341_6W0 | 6W0 | n/a | 51049245 | CHEMBL4066708 | ~{N}-[3-(methoxymethyl)phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide | n/a | |
| 5 | O60341_6W1 | 6W1 | n/a | 118913652 | CHEMBL4081995 | 4-methyl-~{N}-[2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide | n/a | |
| 6 | O60341_6W3 | 6W3 | n/a | 118913699 | CHEMBL4068323 | 4-methyl-~{N}-[2-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide | n/a | |
| 7 | O60341_6X0 | 6X0 | n/a | 118918087 | CHEMBL4069817 | 4-ethyl-~{N}-[3-(methoxymethyl)-2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide | n/a | |
| 8 | O60341_6X3 | 6X3 | n/a | 118913697 | CHEMBL4061953 | 4-methyl-N-[4-[[4-[(1-methyl-4-piperidyl)oxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide | n/a | |
| 9 | O60341_6X5 | 6X5 | n/a | 118931167 | CHEMBL4090812 | ~{N}-[3-(ethoxymethyl)-2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide | n/a | |
| 10 | O60341_767 | 767 | n/a | 137348568 | CHEMBL5419693 | N2-(3-(dimethylamino)propyl)-6,7-dimethoxy-N4,N4-dimethylquinazoline-2,4-diamine | n/a | |
| 11 | O60341_7UQ | 7UQ | n/a | 163321756 | n/a | 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-3-yl)methoxy]phenyl]propanal | n/a | |
| 12 | O60341_7UW | 7UW | n/a | 163321757 | n/a | 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-4-yl)methoxy]phenyl]propanal | n/a | |
| 13 | O60341_8A2 | 8A2 | n/a | 164889268 | n/a | 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal | n/a | |
| 14 | O60341_8WC | 8WC | n/a | 127027348 | CHEMBL3759201 | 4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzenecarbonitrile | n/a | |
| 15 | O60341_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 16 | O60341_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 17 | O60341_CW0 | CW0 | n/a | 130453587 | n/a | piperidin-4-ylmethyl 4-fluoranyl-4-[[[(1~{R},2~{S})-2-phenylcyclopropyl]amino]methyl]piperidine-1-carboxylate | n/a | |
| 18 | O60341_D3U | D3U | n/a | 146672915 | n/a | 2-PCPA derivative | n/a | |
| 19 | O60341_D51 | D51 | n/a | 137349155 | n/a | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate | n/a | |
| 20 | O60341_D52 | D52 | n/a | n/a | n/a | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-[(1S)-1-azanyl-1,3-diphenyl-propyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4aH-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate | n/a | |
| 21 | O60341_D69 | D69 | n/a | n/a | n/a | [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | n/a | |
| 22 | O60341_D70 | D70 | n/a | n/a | n/a | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate | n/a | |
| 23 | O60341_D73 | D73 | n/a | n/a | n/a | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate | n/a | |
| 24 | O60341_DJ0 | DJ0 | n/a | 146018668 | n/a | 3-[3,5-bis(fluoranyl)-2-phenylmethoxy-phenyl]propanal | n/a | |
| 25 | O60341_DJC | DJC | n/a | 146018669 | n/a | 3-[4-[5-fluoranyl-2-(trifluoromethyl)phenyl]phenyl]propanal | n/a | |
| 26 | O60341_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 27 | O60341_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 28 | O60341_E11 | E11 | n/a | 46174171 | CHEMBL1232432 | N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6,7-dimethoxyquinazoline-2,4-diamine | n/a | |
| 29 | O60341_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 30 | O60341_F2N | F2N | n/a | 23631921 | n/a | [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE | n/a | |
| 31 | O60341_FA8 | FA8 | n/a | 49866964 | n/a | [[(2R,3S,4S)-5-[(4AS)-7,8-DIMETHYL-2,4-DIOXO-4A,5-DIHYDROBENZO[G]PTERIDIN-10-YL]-2,3,4-TRIHYDROXY-PENTOXY]-HYDROXY-PHOSPHORYL] [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL HYDROGEN PHOSPHATE | n/a | |
| 32 | O60341_FAD | FAD | DB03147 | 643975 | CHEMBL1232653 | FLAVIN-ADENINE DINUCLEOTIDE | n/a | |
| 33 | O60341_FAJ | FAJ | n/a | 16750117 | n/a | FAD-trans-2-Phenylcyclopropylamine Adduct | n/a | |
| 34 | O60341_FDA | FDA | n/a | 446013;5288205;101960651; | n/a | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE | n/a | |
| 35 | O60341_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 36 | O60341_HG | HG | n/a | 26623 | n/a | MERCURY (II) ION | n/a | |
| 37 | O60341_HUF | HUF | n/a | 155818543 | n/a | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate | n/a | |
| 38 | O60341_I00 | I00 | n/a | 165368445 | n/a | ~{N}-(oxan-4-yl)-5-(3-oxidanylidenepropyl)thiophene-3-carboxamide | n/a | |
| 39 | O60341_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
| 40 | O60341_KWM | KWM | n/a | 137349665 | n/a | [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[(9~{S},11~{R})-15,16-dimethyl-11-oxidanyl-5,7-bis(oxidanylidene)-9-phenyl-2,4,6,12-tetrazabicyclo[11.4.0]heptadeca-1(17),13,15-trien-2-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate | n/a | |
| 41 | O60341_KXM | KXM | n/a | 138455176 | n/a | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3R,4R)-5-[(4aR)-7,8-dimethyl-2,4-dioxo-5-(2-phenylethyl)-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) | n/a | |
| 42 | O60341_M80 | M80 | n/a | 49867278 | n/a | 3-[4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)PHENYL]PROPANOIC ACID | n/a | |
| 43 | O60341_M84 | M84 | n/a | 17341529 | CHEMBL1234186 | 3-{4-[(PHENYLCARBONYL)AMINO]PHENYL}PROPANOIC ACID | n/a | |
| 44 | O60341_M8A | M8A | n/a | 137349736 | n/a | benzyl (2R)-2-{[4-(3-oxopropyl)phenyl]carbamoyl}pyrrolidine-1-carboxylate | n/a | |
| 45 | O60341_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 46 | O60341_MLA | MLA | DB02175 | 867;23511544; | CHEMBL7942 | MALONIC ACID | n/a | |
| 47 | O60341_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 48 | O60341_N4K | N4K | n/a | 132138957 | CHEMBL4639413 | 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole | n/a | |
| 49 | O60341_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 50 | O60341_NH4 | NH4 | n/a | 223;16741146; | n/a | AMMONIUM ION | n/a | |
| 51 | O60341_NY8 | NY8 | n/a | 156009002 | CHEMBL5178765 | ~{N}2-[3-(dimethylamino)propyl]-6,7-dimethoxy-~{N}4-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]quinazoline-2,4-diamine | n/a | |
| 52 | O60341_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 53 | O60341_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 54 | O60341_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 55 | O60341_TCA | TCA | DB18313 | 444539 | CHEMBL27246 | PHENYLETHYLENECARBOXYLIC ACID | n/a | |
| 56 | O60341_TCF | TCF | n/a | 12273139 | n/a | 3-(4-BROMOPHENYL)PROPANAMIDE | n/a | |
| 57 | O60341_THG | THG | DB02031 | 5289465;5460413;135398650; | n/a | (6S)-5,6,7,8-TETRAHYDROFOLATE | n/a | |
| 58 | O60341_TLA | TLA | DB09459 | 444305 | CHEMBL1236315 | L(+)-TARTARIC ACID | n/a | |
| 59 | O60341_V0Y | V0Y | n/a | 118483201 | CHEMBL4651180 | 4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile | n/a | |
| 60 | O60341_DB16446 | n/a | DB16446 | n/a | n/a | Vafidemstat | inhibitor |