Gene name: JAK2
Protein name: Tyrosine-protein kinase JAK2
List of molecules and drugs that interact with protein O60674
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O60674_046 | 046 | n/a | 59596344 | CHEMBL4799398 | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide | n/a | |
| 2 | O60674_0NH | 0NH | n/a | 56973424 | CHEMBL2152409 | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | n/a | |
| 3 | O60674_0NU | 0NU | n/a | 53341457 | CHEMBL2152300 | 3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl]-3-oxopropanenitrile | n/a | |
| 4 | O60674_0NV | 0NV | n/a | 56973425 | CHEMBL2152305 | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | n/a | |
| 5 | O60674_0TP | 0TP | n/a | 53497571 | CHEMBL1938643 | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | n/a | |
| 6 | O60674_0X2 | 0X2 | n/a | 137347906 | n/a | 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | n/a | |
| 7 | O60674_0X5 | 0X5 | n/a | 49839561 | CHEMBL2387224 | 2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | n/a | |
| 8 | O60674_15V | 15V | n/a | 70496411 | CHEMBL2178806 | N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 9 | O60674_17P | 17P | n/a | 56594787 | n/a | 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide | n/a | |
| 10 | O60674_1J5 | 1J5 | n/a | n/a | CHEMBL2386633 | trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | n/a | |
| 11 | O60674_1K3 | 1K3 | n/a | 44556112 | CHEMBL2414544 | 5-(4-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | n/a | |
| 12 | O60674_1M3 | 1M3 | n/a | 16722832 | CHEMBL1995703 | N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | n/a | |
| 13 | O60674_1P5 | 1P5 | n/a | 44251513 | n/a | (3S)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-N,N-diethylpiperidine-3-carboxamide | n/a | |
| 14 | O60674_1P6 | 1P6 | n/a | 44159834 | n/a | 3-(6-{[(1S)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | n/a | |
| 15 | O60674_1RS | 1RS | n/a | 57339438 | CHEMBL2152306 | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | n/a | |
| 16 | O60674_2HB | 2HB | DB14845 | 49831257 | CHEMBL3301607 | N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | n/a | |
| 17 | O60674_2TA | 2TA | DB12500 | 16722836 | CHEMBL1287853 | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | inhibitor | |
| 18 | O60674_35R | 35R | DB05169 | 135398495 | CHEMBL495727 | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea | n/a | |
| 19 | O60674_36H | 36H | n/a | 139600335 | CHEMBL4447631 | 2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol | n/a | |
| 20 | O60674_3JW | 3JW | DB11817 | 44205240 | CHEMBL2105759 | Baricitinib | inhibitor | |
| 21 | O60674_3KC | 3KC | n/a | 135566507 | n/a | 3-chloro-4-(4H-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | n/a | |
| 22 | O60674_3O4 | 3O4 | n/a | 24877326 | CHEMBL1077458 | N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | n/a | |
| 23 | O60674_3YT | 3YT | n/a | 44462758 | CHEMBL2177736 | 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | n/a | |
| 24 | O60674_467 | 467 | n/a | 24887096 | n/a | N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-N-(2,2,2-trifluoroethyl)-D-alaninamide | n/a | |
| 25 | O60674_4HW | 4HW | n/a | 58976958 | n/a | N~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1H-1,2,4-triazole-3,5-diamine | n/a | |
| 26 | O60674_4HZ | 4HZ | n/a | 57597892 | n/a | N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N-(2,2,2-trifluoroethyl)-L-alaninamide | n/a | |
| 27 | O60674_4LY | 4LY | n/a | 156587306 | n/a | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | n/a | |
| 28 | O60674_4OK | 4OK | n/a | 66604359 | CHEMBL3589164 | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9H-carbazole-1-carboxamide | n/a | |
| 29 | O60674_4SP | 4SP | DB07126 | 4566 | CHEMBL319467 | O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE | n/a | |
| 30 | O60674_50O | 50O | n/a | 91827515 | CHEMBL3622127 | N,N-dicyclopropyl-6-[(2S)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | n/a | |
| 31 | O60674_50V | 50V | DB12591 | 50922691 | CHEMBL3545215 | N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | modulator | |
| 32 | O60674_50W | 50W | n/a | 58180596 | CHEMBL3622137 | N,N-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | n/a | |
| 33 | O60674_50Y | 50Y | n/a | 91827514 | CHEMBL3622131 | N,N-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | n/a | |
| 34 | O60674_584 | 584 | n/a | 44141269 | CHEMBL3604889 | (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one | n/a | |
| 35 | O60674_5B1 | 5B1 | n/a | 817910 | CHEMBL465091 | 5-bromo-1H-indazol-3-amine | n/a | |
| 36 | O60674_5B2 | 5B2 | DB07161 | 11492186 | CHEMBL500779 | 5-phenyl-1H-indazol-3-amine | inhibitor | IC50(nM) = 1600.0 |
| 37 | O60674_5B3 | 5B3 | DB07162 | 24963047 | CHEMBL480411 | 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide | n/a | IC50(nM) = 78.0 |
| 38 | O60674_5BS | 5BS | n/a | 121499143 | CHEMBL4554938 | 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide | n/a | |
| 39 | O60674_5W2 | 5W2 | n/a | 118889467 | CHEMBL4760892 | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide | n/a | |
| 40 | O60674_6DP | 6DP | n/a | 1481965 | CHEMBL1703303 | ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide | n/a | |
| 41 | O60674_6TP | 6TP | n/a | 53497572 | CHEMBL1938654 | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide | n/a | |
| 42 | O60674_7DZ | 7DZ | n/a | 44141268 | n/a | (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one | n/a | |
| 43 | O60674_7GS | 7GS | n/a | 135567296 | CHEMBL3644620 | {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone | n/a | |
| 44 | O60674_7GT | 7GT | n/a | 123132925 | n/a | {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3R)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | n/a | |
| 45 | O60674_7GV | 7GV | n/a | 53344620 | CHEMBL4068357 | {(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | n/a | |
| 46 | O60674_7GX | 7GX | n/a | 135567295 | CHEMBL4101534 | 6-(2-ethyl-4-hydroxyphenyl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide | n/a | |
| 47 | O60674_7GY | 7GY | n/a | 135567294 | CHEMBL4096219 | 6-(2-ethyl-4-hydroxyphenyl)-1H-indazole-3-carboxamide | n/a | |
| 48 | O60674_7GZ | 7GZ | n/a | 135567293 | CHEMBL3928932 | 4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-ethylphenol | n/a | |
| 49 | O60674_88A | 88A | n/a | 49838138 | CHEMBL2062803 | 8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | n/a | |
| 50 | O60674_8MY | 8MY | n/a | 127053606 | CHEMBL4072814 | 4-({4-amino-6-[3-(hydroxymethyl)-1H-pyrazol-1-yl]pyrimidin-2-yl}amino)benzonitrile | n/a | |
| 51 | O60674_953 | 953 | n/a | 66570958 | CHEMBL3330125 | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide | n/a | |
| 52 | O60674_9HR | 9HR | n/a | 162423122 | CHEMBL5075556 | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{S})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | n/a | |
| 53 | O60674_9I2 | 9I2 | n/a | 162423121 | CHEMBL5078647 | 4-[2-azanyl-8-[[(2~{S})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | n/a | |
| 54 | O60674_9I5 | 9I5 | n/a | 162423120 | CHEMBL5088804 | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | n/a | |
| 55 | O60674_9I8 | 9I8 | n/a | 162423119 | CHEMBL5084861 | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | n/a | |
| 56 | O60674_9T6 | 9T6 | n/a | n/a | n/a | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | n/a | |
| 57 | O60674_9ZS | 9ZS | n/a | 67387753 | CHEMBL4064189 | N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | n/a | |
| 58 | O60674_ACE | ACE | n/a | 177 | CHEMBL170365 | ACETYL GROUP | n/a | |
| 59 | O60674_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 60 | O60674_AD5 | AD5 | DB07340 | 210332 | CHEMBL188343 | N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine | n/a | |
| 61 | O60674_AQG | AQG | n/a | 10202471 | CHEMBL1802728 | 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide | n/a | |
| 62 | O60674_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 63 | O60674_AZ5 | AZ5 | DB12588 | 16659841 | CHEMBL1231124 | 5-CHLORO-N2-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHYL]-N4-(5-METHYL-1H-PYRAZOL-3-YL)PYRIMIDINE-2,4-DIAMINE | modulator | |
| 64 | O60674_BJG | BJG | n/a | 76210601 | CHEMBL3330121 | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1H-pyrrole-3-carboxamide | n/a | |
| 65 | O60674_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 66 | O60674_D7D | D7D | DB14973 | n/a | CHEMBL3655081 | N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | inhibitor | |
| 67 | O60674_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 68 | O60674_DQX | DQX | n/a | 46398810 | CHEMBL1092926 | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline | n/a | |
| 69 | O60674_E3W | E3W | n/a | 163359801 | CHEMBL5191140 | 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid | n/a | |
| 70 | O60674_E4V | E4V | n/a | 56903404 | n/a | 4-(5-aminopyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine | n/a | |
| 71 | O60674_E8I | E8I | n/a | 163321785 | CHEMBL5196142 | (2S)-2-[({4-[(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}carbamoyl)amino]-4-phenylbutanoic acid | n/a | |
| 72 | O60674_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 73 | O60674_F9J | F9J | n/a | 71300296 | CHEMBL2381980 | 5-FLUORO-4-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHOXY]-N-(5-METHYL-1H-PYRAZOL-3-YL)-6-MORPHOLINO-PYRIMIDIN-2-AMINE | n/a | |
| 74 | O60674_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 75 | O60674_I6C | I6C | n/a | 153583901 | n/a | 3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | n/a | |
| 76 | O60674_IK1 | IK1 | n/a | 6419765 | CHEMBL404609 | 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE | n/a | |
| 77 | O60674_IZA | IZA | DB04716 | 5494425 | CHEMBL21156 | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE | inhibitor | IC50(nM) = 1.0 |
| 78 | O60674_J2I | J2I | n/a | 49859752 | CHEMBL1615027 | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | n/a | |
| 79 | O60674_J9D | J9D | n/a | 134812755 | n/a | 4-({4-amino-6-[4-(2-hydroxyethyl)-1H-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrile | n/a | |
| 80 | O60674_JAK | JAK | n/a | 57339437 | CHEMBL2159141 | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | n/a | |
| 81 | O60674_JZH | JZH | n/a | 49867181 | n/a | (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one | n/a | |
| 82 | O60674_L0I | L0I | DB08067 | 135566363 | n/a | 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM | n/a | |
| 83 | O60674_LMM | LMM | n/a | 45275254 | CHEMBL3116056 | N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-N4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | n/a | |
| 84 | O60674_M3A | M3A | n/a | 145998260 | n/a | 5-amino-3-[(4-cyanophenyl)amino]-N-phenyl-1H-1,2,4-triazole-1-carboxamide | n/a | |
| 85 | O60674_M3Y | M3Y | n/a | 145998262 | CHEMBL4475907 | 5-amino-N-phenyl-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carboxamide | n/a | |
| 86 | O60674_M4G | M4G | n/a | 145998263 | CHEMBL4476380 | [4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acid | n/a | |
| 87 | O60674_M4P | M4P | n/a | 145998264 | CHEMBL4539227 | [4-({5-amino-3-[(4-cyanophenyl)amino]-1H-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acid | n/a | |
| 88 | O60674_M57 | M57 | n/a | 145998265 | CHEMBL4449644 | 2-[4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbonyl}amino)phenyl]-1,3-oxazole-4-carboxylic acid | n/a | |
| 89 | O60674_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 90 | O60674_MI1 | MI1 | DB08895 | 9926791 | CHEMBL221959 | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | antagonist | |
| 91 | O60674_MLI | MLI | DB02201 | 9084 | n/a | MALONATE ION | n/a | |
| 92 | O60674_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 93 | O60674_NVB | NVB | n/a | 25128110 | CHEMBL1093749 | N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | n/a | |
| 94 | O60674_O19 | O19 | n/a | 57991377 | CHEMBL2208034 | (2R)-N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | n/a | |
| 95 | O60674_OV0 | OV0 | n/a | 164885969 | n/a | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5H-pyrrolo[3,4-b]pyridin-5-one | n/a | |
| 96 | O60674_Q2Q | Q2Q | n/a | 166513901 | n/a | 3,5-diphenyl-2-(trifluoromethyl)-6~{H}-pyrazolo[1,5-a]pyrimidin-7-one | n/a | |
| 97 | O60674_Q7F | Q7F | n/a | 17449326 | n/a | 6-[[methyl-[(3-methylthiophen-2-yl)methyl]amino]methyl]-~{N}4-phenyl-1,3,5-triazine-2,4-diamine | n/a | |
| 98 | O60674_Q8N | Q8N | n/a | 895487 | CHEMBL1549837 | 6-[(1-methylimidazol-2-yl)sulfanylmethyl]-~{N}4-(3-methylphenyl)-1,3,5-triazine-2,4-diamine | n/a | |
| 99 | O60674_Q8U | Q8U | DB12411 | 46215462 | CHEMBL3809489 | 1-(3,4-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2(7),3,5,12,14-hexaen-5-yl)-~{N}3-[(7~{S})-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5~{H}-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine | n/a | |
| 100 | O60674_Q9X | Q9X | n/a | 16303684 | n/a | 6-[[(5-bromanylthiophen-2-yl)methyl-methyl-amino]methyl]-~{N}4-(4-methylphenyl)-1,3,5-triazine-2,4-diamine | n/a | |
| 101 | O60674_QQC | QQC | DB13040 | 46213929 | CHEMBL2107823 | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{N}-(5-methyl-1~{H}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | modulator | |
| 102 | O60674_QUP | QUP | n/a | 118129292 | CHEMBL3403542 | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-2-carboxamide | n/a | |
| 103 | O60674_QZ8 | QZ8 | n/a | 141335958 | CHEMBL4635464 | 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one | n/a | |
| 104 | O60674_R5S | R5S | n/a | 155804521 | n/a | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | n/a | |
| 105 | O60674_R5Y | R5Y | n/a | 155570100 | CHEMBL4745155 | 4-[1-(but-3-en-1-yl)-1H-pyrazol-4-yl]-N-[4-(piperidin-4-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine | n/a | |
| 106 | O60674_R61 | R61 | n/a | 155570098 | n/a | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | n/a | |
| 107 | O60674_R6M | R6M | n/a | 149619121 | CHEMBL4785050 | N-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | n/a | |
| 108 | O60674_R6P | R6P | n/a | 155570095 | CHEMBL4743499 | (3S)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | n/a | |
| 109 | O60674_R6S | R6S | n/a | 149905725 | CHEMBL4762807 | N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | n/a | |
| 110 | O60674_R6V | R6V | n/a | 155570096 | CHEMBL4750568 | (3R)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | n/a | |
| 111 | O60674_RG4 | RG4 | n/a | 50878566 | CHEMBL1287854 | (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | n/a | |
| 112 | O60674_RXT | RXT | DB08877 | 25126798 | CHEMBL1789941 | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | inhibitor | Ki(nM) = 0.1 IC50(nM) = 0.036 Kd(nM) = 0.036 EC50(nM) = 12.0 |
| 113 | O60674_SKE | SKE | n/a | 5330790 | CHEMBL191003 | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide | n/a | |
| 114 | O60674_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 115 | O60674_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 116 | O60674_U8J | U8J | n/a | 155907149 | n/a | N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | n/a | |
| 117 | O60674_U8P | U8P | n/a | 155599226 | n/a | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | n/a | |
| 118 | O60674_UWP | UWP | n/a | 155804555 | CHEMBL4778704 | [3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | n/a | |
| 119 | O60674_V4D | V4D | n/a | 155289126 | CHEMBL5440296 | 4-({4-amino-6-[(1H-indol-5-yl)oxy]-1,3,5-triazin-2-yl}amino)benzene-1-sulfonamide | n/a | |
| 120 | O60674_VJK | VJK | DB12566 | 59422203 | CHEMBL3039513 | (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-[2,2,2-tris(fluoranyl)ethyl]butanamide | n/a | |
| 121 | O60674_VPJ | VPJ | n/a | 16335711 | n/a | N~2~-(4-fluorophenyl)-6-{[(5-{[(oxolan-2-yl)methyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-1,3,5-triazine-2,4-diamine | n/a | |
| 122 | O60674_VPS | VPS | n/a | 155937486 | n/a | 3-({4-amino-6-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}oxy)benzoic acid | n/a | |
| 123 | O60674_VVQ | VVQ | n/a | 57659335 | CHEMBL3330104 | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1H-pyrrole-3-carboxamide | n/a | |
| 124 | O60674_XWW | XWW | n/a | 67300255 | n/a | N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | n/a | |
| 125 | O60674_XZS | XZS | n/a | 149370917 | CHEMBL4744236 | N-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | n/a | |
| 126 | O60674_Y5D | Y5D | n/a | 162394476 | n/a | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile | n/a | |
| 127 | O60674_Y5G | Y5G | n/a | 162394477 | n/a | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile | n/a | |
| 128 | O60674_YDJ | YDJ | DB12242 | 11152667 | CHEMBL2041933 | 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | n/a | |
| 129 | O60674_YSI | YSI | n/a | 168301725 | CHEMBL5395308 | (3R)-3-cyclopentyl-3-[(4M)-4-{5-methyl-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1H-pyrazol-1-yl]propanenitrile | n/a | |
| 130 | O60674_YT0 | YT0 | n/a | 166462621 | CHEMBL5396135 | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | n/a | |
| 131 | O60674_YT8 | YT8 | n/a | 168301726 | CHEMBL5434489 | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | n/a | |
| 132 | O60674_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 133 | O60674_T7I | T7I | n/a | 2810970 | CHEMBL5438956 | 3,5-diphenyl-2-(trifluoromethyl)-1~{H}-pyrazolo[1,5-a]pyrimidin-7-one | n/a | |
| 134 | O60674_6T3 | 6T3 | DB11697 | 46216796 | CHEMBL2035187 | Pacritinib | inhibitor | |
| 135 | O60674_YMX | YMX | DB11986 | 25141092 | CHEMBL1983268 | Entrectinib | inhibitor | |
| 136 | O60674_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 137 | O60674_DB15035 | n/a | DB15035 | n/a | n/a | Zanubrutinib | inhibitor | |
| 138 | O60674_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor |