Gene name: ROCK2
Protein name: Rho-associated protein kinase
List of molecules and drugs that interact with protein O75116
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O75116_1WU | 1WU | n/a | 58333270 | CHEMBL3546188 | 6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3H)-ol | n/a | |
| 2 | O75116_3SG | 3SG | n/a | 71505859 | CHEMBL3426633 | methyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoate | n/a | |
| 3 | O75116_5YS | 5YS | n/a | 164575485 | CHEMBL5171140 | ~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide | n/a | |
| 4 | O75116_81G | 81G | n/a | n/a | CHEMBL4213805 | (1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one | n/a | |
| 5 | O75116_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 6 | O75116_J0P | J0P | n/a | 134823958 | CHEMBL4522042 | N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide | n/a | |
| 7 | O75116_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 8 | O75116_O1S | O1S | n/a | 71147224;136333907; | CHEMBL4083927 | 6-(5-methyl-1H-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3H)-one | n/a | |
| 9 | O75116_O1V | O1V | DB16330 | 53358083;135564531; | CHEMBL4297644 | 2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one | n/a | |
| 10 | O75116_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 11 | O75116_VFA | VFA | n/a | 121363591 | CHEMBL4797055 | N-[(3-methoxyphenyl)methyl]-5H-[1]benzopyrano[3,4-c]pyridine-8-carboxamide | n/a | |
| 12 | O75116_VFS | VFS | n/a | 85469696 | CHEMBL3955445 | N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide | n/a | |
| 13 | O75116_Z8O | Z8O | n/a | 118556629 | CHEMBL5268152 | 4-{4-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]phenyl}phthalazin-1(2H)-one | n/a | |
| 14 | O75116_M77 | M77 | DB08162 | 3547 | CHEMBL38380 | Fasudil | n/a | Ki(nM) = 330.0 IC50(nM) = 71.0 Kd(nM) = 45.0 |
| 15 | O75116_Y27 | Y27 | DB08756 | n/a | CHEMBL559147 | Y-27632 | n/a | Ki(nM) = 60.0 IC50(nM) = 8.3 |
| 16 | O75116_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 17 | O75116_DB13165 | n/a | DB13165 | n/a | n/a | Ripasudil | inhibitor | |
| 18 | O75116_DB13931 | n/a | DB13931 | n/a | n/a | Netarsudil | inhibitor | |
| 19 | O75116_ICQ | ICQ | DB16703 | 11950170 | CHEMBL2005186 | Belumosudil | inhibitor |