Gene name: NR1I2
Protein name: Nuclear receptor subfamily
List of molecules and drugs that interact with protein O75469
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O75469_07F | 07F | n/a | 136334632 | CHEMBL4866041 | 5-benzyl-2-(3-fluoro-2-hydroxyphenyl)-6-methyl-3-(2-phenylethyl)pyrimidin-4(3H)-one | n/a | |
| 2 | O75469_27H | 27H | n/a | 354654 | CHEMBL465040 | ferutinine | n/a | |
| 3 | O75469_27J | 27J | DB11478 | 2999413 | CHEMBL450613 | alpha-zearalanol | n/a | |
| 4 | O75469_2Q4 | 2Q4 | n/a | 57889181 | CHEMBL2398716 | N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide | n/a | |
| 5 | O75469_3WF | 3WF | DB00977 | 5991 | CHEMBL691 | Ethinyl estradiol | agonist | |
| 6 | O75469_3WG | 3WG | n/a | n/a | n/a | Trans-nonachlor | n/a | |
| 7 | O75469_40U | 40U | n/a | 57889327 | CHEMBL2398717 | N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-cyclopropylacetamide | n/a | |
| 8 | O75469_444 | 444 | DB07080 | 447912 | CHEMBL62136 | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | n/a | IC50(nM) = 26.0 EC50(nM) = 8.0 |
| 9 | O75469_4WH | 4WH | n/a | 130471921 | CHEMBL4848816 | 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole | n/a | |
| 10 | O75469_5YU | 5YU | n/a | 57989874 | n/a | N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}thiophene-3-sulfonamide | n/a | |
| 11 | O75469_5YX | 5YX | n/a | 57989748 | n/a | N-[3-(2-tert-butyl-5-{2-[2-(methanesulfonyl)ethyl]pyrimidin-4-yl}-1,3-thiazol-4-yl)-2-fluorophenyl]-2,5-difluorobenzene-1-sulfonamide | n/a | |
| 12 | O75469_CDZ | CDZ | n/a | 373677 | n/a | 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one | n/a | |
| 13 | O75469_CL6 | CL6 | DB00257 | 2812 | CHEMBL104 | 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE | activator | EC50(nM) = 2700.0 |
| 14 | O75469_D7E | D7E | n/a | 59177179 | CHEMBL3605516 | 4-chloro-N-[(1R)-1-[1-ethyl-6-(trifluoromethyl)benzimidazol-2-yl]ethyl]benzenesulfonamide | n/a | |
| 15 | O75469_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 16 | O75469_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 17 | O75469_EST | EST | DB00783 | 5757 | CHEMBL135 | ESTRADIOL | binder | |
| 18 | O75469_G3L | G3L | n/a | 72320 | CHEMBL4740267 | Nomilin | n/a | |
| 19 | O75469_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 20 | O75469_GRH | GRH | n/a | 124125518 | n/a | (2~{R})-~{N}-[4-(3-chloranylphenoxy)-3-sulfamoyl-phenyl]-2-phenyl-propanamide | n/a | |
| 21 | O75469_HCJ | HCJ | n/a | 67060124 | CHEMBL4283963 | (2S)-2-({[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy}methyl)-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one | n/a | |
| 22 | O75469_HYF | HYF | DB01892 | n/a | n/a | 4-HYDROXY-5-ISOBUTYRYL-6-METHYL-1,3,7-TRIS-(3-METHYL-BUT-2-ENYL)-6-(4-METHYL-PENT-3-ENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE | n/a | |
| 23 | O75469_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | n/a | |
| 24 | O75469_KUB | KUB | n/a | 134585452 | CHEMBL4580996 | 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide | n/a | |
| 25 | O75469_L7D | L7D | n/a | 118212096 | CHEMBL4591380 | 1,1,1,3,3,3-hexafluoro-2-(4-{1-[(4-fluorophenyl)sulfonyl]cyclopentyl}phenyl)propan-2-ol | n/a | |
| 26 | O75469_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 27 | O75469_N6H | N6H | n/a | 154573643 | CHEMBL4740641 | [2-[(3-chlorophenyl)methylamino]-7-methoxy-1,3-benzoxazol-5-yl]-(2,2-dimethylmorpholin-4-yl)methanone | n/a | |
| 28 | O75469_NQD | NQD | n/a | 146014941 | n/a | (2Z,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-1-benzopyran-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid | n/a | |
| 29 | O75469_P06 | P06 | DB08912 | 44462760 | CHEMBL2028663 | Dabrafenib | n/a | EC50(nM) = 87.0 |
| 30 | O75469_PNU | PNU | DB08414 | 446309 | CHEMBL280541 | 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE | n/a | |
| 31 | O75469_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 32 | O75469_QCG | QCG | n/a | 56929814 | CHEMBL4454255 | (2S)-tert-butoxy[7-(8-fluoro-5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid | n/a | |
| 33 | O75469_RFP | RFP | DB01045 | 135398735;136262914; | CHEMBL374478 | RIFAMPICIN | agonist | EC50(nM) = 190.0 |
| 34 | O75469_S65 | S65 | n/a | 71317194 | n/a | heptachlor endo-epoxide | n/a | |
| 35 | O75469_S68 | S68 | n/a | n/a | n/a | endosulfan | n/a | |
| 36 | O75469_S6E | S6E | n/a | 12303028 | n/a | (-)cis-chlordane | n/a | |
| 37 | O75469_S6H | S6H | n/a | 1550472 | n/a | (+)cis-chlordane | n/a | |
| 38 | O75469_S6T | S6T | n/a | 91644 | CHEMBL1867271 | pretilachlor | n/a | |
| 39 | O75469_S6W | S6W | n/a | 15278226 | n/a | fipronil | n/a | |
| 40 | O75469_S6Z | S6Z | n/a | 29732 | CHEMBL1080648 | oxadiazon | n/a | |
| 41 | O75469_TBY | TBY | DB08601 | 5948 | n/a | tributylstannanyl | n/a | |
| 42 | O75469_VA0 | VA0 | n/a | n/a | n/a | Rifamycin S | n/a | |
| 43 | O75469_WQB | WQB | n/a | 166642336 | n/a | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylbenzenesulfonamide | n/a | |
| 44 | O75469_X1D | X1D | n/a | 168654834 | n/a | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-[(4-phenoxyphenyl)methyl]benzenesulfonamide | n/a | |
| 45 | O75469_XGH | XGH | n/a | 131953519 | CHEMBL4214210 | 2-[(2S)-4-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide | n/a | |
| 46 | O75469_Y5B | Y5B | n/a | 166642337 | n/a | N-[([1,1'-biphenyl]-4-yl)methyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamide | n/a | |
| 47 | O75469_SRL | SRL | DB04466 | 446313 | CHEMBL458767 | [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER | n/a | EC50(nM) = 60.0 |
| 48 | O75469_VIV | VIV | DB00163 | 14985 | CHEMBL47 | Vitamin E | n/a | |
| 49 | O75469_DB00239 | n/a | DB00239 | n/a | n/a | Oxiconazole | partial agonist | |
| 50 | O75469_DB00252 | n/a | DB00252 | n/a | n/a | Phenytoin | n/a | |
| 51 | O75469_DES | DES | DB00255 | 448537 | CHEMBL411 | Diethylstilbestrol | n/a | |
| 52 | O75469_DB00312 | n/a | DB00312 | n/a | n/a | Pentobarbital | activator | |
| 53 | O75469_SNL | SNL | DB00421 | 5833 | CHEMBL1393 | Spironolactone | agonist | |
| 54 | O75469_DB00431 | n/a | DB00431 | n/a | n/a | Lindane | n/a | |
| 55 | O75469_DB00499 | n/a | DB00499 | n/a | n/a | Flutamide | n/a | |
| 56 | O75469_RIT | RIT | DB00503 | 392622 | CHEMBL163 | Ritonavir | activator | EC50(nM) = 4000.0 |
| 57 | O75469_AQ4 | AQ4 | DB00530 | 176870 | CHEMBL553 | Erlotinib | agonist | |
| 58 | O75469_DB00531 | n/a | DB00531 | n/a | n/a | Cyclophosphamide | n/a | |
| 59 | O75469_DB00532 | n/a | DB00532 | n/a | n/a | Mephenytoin | activator | |
| 60 | O75469_N6W | N6W | DB00564 | 2554 | CHEMBL108 | Carbamazepine | activator | |
| 61 | O75469_CTX | CTX | DB00675 | 2733526 | CHEMBL83 | Tamoxifen | n/a | |
| 62 | O75469_DB00682 | n/a | DB00682 | n/a | n/a | Warfarin | n/a | |
| 63 | O75469_DB00754 | n/a | DB00754 | n/a | n/a | Ethotoin | activator | |
| 64 | O75469_486 | 486 | DB00834 | 55245 | CHEMBL1276308 | Mifepristone | n/a | |
| 65 | O75469_DB00849 | n/a | DB00849 | n/a | n/a | Methylphenobarbital | activator | |
| 66 | O75469_DB01026 | n/a | DB01026 | n/a | n/a | Ketoconazole | antagonist | |
| 67 | O75469_DB01039 | n/a | DB01039 | n/a | n/a | Fenofibrate | partial agonist | |
| 68 | O75469_DB01068 | n/a | DB01068 | n/a | n/a | Clonazepam | partial agonist | |
| 69 | O75469_DB01110 | n/a | DB01110 | n/a | n/a | Miconazole | partial agonist | |
| 70 | O75469_C5U | C5U | DB01115 | 4485 | CHEMBL193 | Nifedipine | agonist | |
| 71 | O75469_DB01127 | n/a | DB01127 | n/a | n/a | Econazole | partial agonist | |
| 72 | O75469_DB01138 | n/a | DB01138 | n/a | n/a | Sulfinpyrazone | activator | |
| 73 | O75469_UQA | UQA | DB01174 | 4763 | CHEMBL40 | Phenobarbital | activator | |
| 74 | O75469_DB01181 | n/a | DB01181 | n/a | n/a | Ifosfamide | n/a | |
| 75 | O75469_RXM | RXM | DB01220 | 6436173 | CHEMBL1617 | Rifaximin | agonist | EC50(nM) = 2200.0 |
| 76 | O75469_TA1 | TA1 | DB01229 | 36314 | CHEMBL428647 | Paclitaxel | inducer | |
| 77 | O75469_DEX | DEX | DB01234 | 5743 | CHEMBL384467 | Dexamethasone | agonist | |
| 78 | O75469_TXL | TXL | DB01248 | 148124 | CHEMBL92 | Docetaxel | binder | |
| 79 | O75469_PEM | PEM | DB01393 | 39042 | CHEMBL264374 | Bezafibrate | partial agonist | |
| 80 | O75469_GEN | GEN | DB01645 | 5280961 | CHEMBL44 | Genistein | n/a | |
| 81 | O75469_AND | AND | DB01708 | 5881 | CHEMBL90593 | Prasterone | activator | |
| 82 | O75469_DB01892 | n/a | DB01892 | n/a | n/a | Hyperforin | n/a | |
| 83 | O75469_STL | STL | DB02709 | 445154 | CHEMBL165 | Resveratrol | n/a | |
| 84 | O75469_PLO | PLO | DB02789 | 8955 | CHEMBL253363 | Pregnenolone | n/a | |
| 85 | O75469_QUE | QUE | DB04216 | 5280343 | CHEMBL50 | Quercetin | activator | |
| 86 | O75469_OHT | OHT | DB04468 | 449459 | CHEMBL489 | Afimoxifene | n/a | |
| 87 | O75469_FGT | FGT | DB04824 | 4764 | CHEMBL63857 | Phenolphthalein | n/a | |
| 88 | O75469_DB04930 | n/a | DB04930 | n/a | n/a | Permethrin | n/a | |
| 89 | O75469_38O | 38O | DB05928 | 135398510 | CHEMBL522892 | Dovitinib | suppressor | |
| 90 | O75469_JN3 | JN3 | DB06777 | 10133 | CHEMBL240597 | Chenodeoxycholic acid | n/a | |
| 91 | O75469_HXS | HXS | DB07931 | 192197 | CHEMBL9225 | Hexestrol | n/a | |
| 92 | O75469_TCL | TCL | DB08604 | 5564 | CHEMBL849 | Triclosan | n/a | |
| 93 | O75469_T27 | T27 | DB08864 | 6451164 | CHEMBL175691 | Rilpivirine | agonist | |
| 94 | O75469_AYR | AYR | DB12582 | 638024 | CHEMBL43185 | Piperine | n/a | |
| 95 | O75469_DB13179 | n/a | DB13179 | n/a | n/a | Troleandomycin | activator | |
| 96 | O75469_F5A | F5A | DB13873 | 64929 | CHEMBL981 | Fenofibric acid | partial agonist | |
| 97 | O75469_DB13952 | n/a | DB13952 | n/a | n/a | Estradiol acetate | n/a | |
| 98 | O75469_DB13953 | n/a | DB13953 | n/a | n/a | Estradiol benzoate | n/a | |
| 99 | O75469_DB13954 | n/a | DB13954 | n/a | n/a | Estradiol cypionate | n/a | |
| 100 | O75469_DB13955 | n/a | DB13955 | n/a | n/a | Estradiol dienanthate | n/a | |
| 101 | O75469_DB13956 | n/a | DB13956 | n/a | n/a | Estradiol valerate | n/a | |
| 102 | O75469_DB14001 | n/a | DB14001 | n/a | n/a | alpha-Tocopherol succinate | n/a | |
| 103 | O75469_DB14002 | n/a | DB14002 | n/a | n/a | D-alpha-Tocopherol acetate | n/a | |
| 104 | O75469_DB14649 | n/a | DB14649 | n/a | n/a | Dexamethasone acetate | agonist |