Gene name: EED
Protein name: Polycomb protein EED
List of molecules and drugs that interact with protein O75530
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O75530_51A | 51A | n/a | 156340524 | CHEMBL4856470 | N-[5-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methylamino]-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzamide | n/a | |
| 2 | O75530_52R | 52R | n/a | 162368300 | CHEMBL4860329 | N5-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-N8-methyl-N8-(1-methylpyrazol-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidine-5,8-diamine | n/a | |
| 3 | O75530_54N | 54N | n/a | 162368301 | CHEMBL4863385 | 8-[6-[(dimethylamino)methyl]-2-methyl-pyridin-3-yl]-5-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methylamino]-2H-pyrido[3,4-d]pyridazin-1-one | n/a | |
| 4 | O75530_6BN | 6BN | n/a | 118616826 | n/a | 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one | n/a | |
| 5 | O75530_6PU | 6PU | n/a | 124037107 | n/a | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine | n/a | |
| 6 | O75530_73K | 73K | n/a | 123132228 | CHEMBL4065484 | N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | n/a | |
| 7 | O75530_74D | 74D | n/a | 137348557 | n/a | 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide | n/a | |
| 8 | O75530_7VV | 7VV | n/a | 137348667 | n/a | (6S)-6-[(2-fluoro-5-methoxyphenyl)methyl]-1-(propan-2-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine | n/a | |
| 9 | O75530_7VY | 7VY | n/a | 40427923 | n/a | (3R)-3-[(3-methoxyphenyl)methyl]piperidine | n/a | |
| 10 | O75530_7W7 | 7W7 | n/a | 123132938 | n/a | (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide | n/a | |
| 11 | O75530_7WD | 7WD | n/a | 123132939 | n/a | (6S)-6-[(2H-1,3-benzodioxol-4-yl)methyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine | n/a | |
| 12 | O75530_7XG | 7XG | n/a | 124220775 | CHEMBL4068192 | 2-[4-(4-{(3S,4R)-4-(dimethylamino)-1-[(2-fluoro-6-methylphenyl)methyl]pyrrolidin-3-yl}phenyl)-1H-pyrazol-1-yl]acetamide | n/a | |
| 13 | O75530_82D | 82D | n/a | 124220776 | CHEMBL4075197 | (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | n/a | |
| 14 | O75530_82G | 82G | n/a | 123132216 | CHEMBL4080018 | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | n/a | |
| 15 | O75530_9JL | 9JL | n/a | 155788096 | n/a | (4S)-8-{4-[(dimethylamino)methyl]-2-methylphenyl}-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile | n/a | |
| 16 | O75530_9L0 | 9L0 | n/a | 152324986 | n/a | (4R)-8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile | n/a | |
| 17 | O75530_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | O75530_CJD | CJD | DB14799 | 118572065 | CHEMBL4080228 | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | n/a | |
| 19 | O75530_CJG | CJG | n/a | 86723730 | CHEMBL3911017 | 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | n/a | |
| 20 | O75530_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 21 | O75530_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | O75530_EJR | EJR | DB19205 | 121412508 | CHEMBL4755618 | N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | inhibitor | |
| 23 | O75530_EJU | EJU | n/a | 138742282 | n/a | 8-[4-[(dimethylamino)methyl]phenyl]-N-[(2-methoxyphenyl)methyl]-[1,2,4]triazolo[4,3-a]pyridin-5-amine | n/a | |
| 24 | O75530_EKF | EKF | n/a | 121432925 | CHEMBL5178353 | N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | n/a | |
| 25 | O75530_EKR | EKR | n/a | 163183785 | CHEMBL5179144 | N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | n/a | |
| 26 | O75530_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 27 | O75530_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 28 | O75530_L9T | L9T | n/a | 126463397 | CHEMBL5191512 | N-(1,3-benzodioxol-4-ylmethyl)-4-methyl-5-(1-methylpyrazol-3-yl)-1,3-thiazol-2-amine | n/a | |
| 29 | O75530_L9W | L9W | n/a | 121433042 | n/a | N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | n/a | |
| 30 | O75530_LQA | LQA | n/a | n/a | n/a | 4-azanylidene-2-(3-methoxy-4-propan-2-yloxy-phenyl)-6,7-dihydro-[1,3]benzodioxolo[6,5-a]quinolizine-3-carbonitrile | n/a | |
| 31 | O75530_LQB | LQB | n/a | 2905908 | CHEMBL5282599 | 2-[3-(3,5-dimethylpyrazol-1-yl)-4-nitro-phenyl]-3,4-dihydro-1H-isoquinoline | n/a | |
| 32 | O75530_LQD | LQD | n/a | 124037093 | CHEMBL4074159 | (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine | n/a | |
| 33 | O75530_LQE | LQE | n/a | 137349702 | CHEMBL4097892 | (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline | n/a | |
| 34 | O75530_LQF | LQF | n/a | 29111296 | CHEMBL4096234 | 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile | n/a | |
| 35 | O75530_LQG | LQG | n/a | 137349703 | CHEMBL4063655 | 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile | n/a | |
| 36 | O75530_LQH | LQH | n/a | 10015659 | CHEMBL310238 | 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline | n/a | |
| 37 | O75530_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 38 | O75530_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 39 | O75530_NDS | NDS | DB02618 | 5221296 | CHEMBL1234674 | ETHYL DIMETHYL AMMONIO PROPANE SULFONATE | n/a | |
| 40 | O75530_PR | PR | n/a | 185491 | n/a | PRASEODYMIUM ION | n/a | |
| 41 | O75530_PV5 | PV5 | n/a | 156022749 | CHEMBL4748924 | 5-fluoranyl-4-[[[8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl]amino]methyl]-2,3-dihydro-1-benzofuran-7-carbonitrile | n/a | |
| 42 | O75530_Q3A | Q3A | n/a | 146681125 | CHEMBL4635558 | 8-(2,6-dimethylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine | n/a | |
| 43 | O75530_Q3D | Q3D | n/a | 146681126 | CHEMBL4637520 | 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine | n/a | |
| 44 | O75530_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 45 | O75530_UNX | UNX | n/a | |||||
| 46 | O75530_XB7 | XB7 | DB00637 | 2247 | CHEMBL296419 | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine | n/a | Ki(nM) = 23010.0 IC50(nM) = 93800.0 |
| 47 | O75530_YT3 | YT3 | n/a | 168049 | n/a | YTTRIUM (III) ION | n/a | |
| 48 | O75530_ZMY | ZMY | n/a | 156621368 | n/a | (9aP,12aR)-4-(2,2-difluoropropyl)-12-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one | n/a | |
| 49 | O75530_ZNG | ZNG | n/a | 156621369 | n/a | (9aM,12aS)-12-{[(5-fluoro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,11,12a-tetraazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one | n/a |