Gene name: IDH1
Protein name: Isocitrate dehydrogenase [NADP]
List of molecules and drugs that interact with protein O75874
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O75874_1BX | 1BX | n/a | 71816506 | CHEMBL2386127 | 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one | n/a | |
| 2 | O75874_1BZ | 1BZ | n/a | 13590964 | CHEMBL2386126 | 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one | n/a | |
| 3 | O75874_33O | 33O | n/a | 87168 | n/a | 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol | n/a | |
| 4 | O75874_42V | 42V | n/a | 122186453 | CHEMBL3605382 | 5-[(E)-(1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl]pyridin-2(1H)-one | n/a | |
| 5 | O75874_42W | 42W | n/a | 122186459 | CHEMBL3605388 | (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one | n/a | |
| 6 | O75874_59D | 59D | n/a | 91864709 | CHEMBL4215717 | (7R)-1-(4-fluorobenzyl)-N-{3-[(1S)-1-hydroxyethyl]phenyl}-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide | n/a | |
| 7 | O75874_6MX | 6MX | n/a | n/a | n/a | 2-[(3~{R})-1-[6-cyclohexylsulfanyl-5-[[(1~{R},3~{S})-5-oxidanyl-2-adamantyl]carbamoyl]pyridin-2-yl]pyrrolidin-3-yl]ethanoic acid | n/a | |
| 8 | O75874_6N3 | 6N3 | n/a | n/a | n/a | (1~{R},5~{S})-3-[6-(3-methylbutoxy)-5-[[(1~{R},3~{S})-5-oxidanyl-2-adamantyl]carbamoyl]pyridin-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid | n/a | |
| 9 | O75874_6VN | 6VN | n/a | 118311107 | n/a | 2-[(4-propan-2-ylphenyl)amino]-1-[(1~{S},5~{S})-3,3,5-trimethylcyclohexyl]benzimidazole-5-carboxylic acid | n/a | |
| 10 | O75874_70P | 70P | n/a | 89490055 | CHEMBL3672097 | (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one | n/a | |
| 11 | O75874_70Q | 70Q | n/a | 4986091 | n/a | 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide | n/a | |
| 12 | O75874_7J2 | 7J2 | n/a | 71542286 | CHEMBL4169151 | (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one | n/a | |
| 13 | O75874_7SU | 7SU | DB18745 | 130306983 | CHEMBL4651002 | (E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbonyl)-3-methyl-1H-indol-4-yl)acrylic acid | n/a | |
| 14 | O75874_9UO | 9UO | DB17097 | 117817422 | CHEMBL4279047 | 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine | inhibitor | |
| 15 | O75874_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 16 | O75874_AKG | AKG | DB08845 | 51;156274072; | CHEMBL1686 | 2-OXOGLUTARIC ACID | n/a | |
| 17 | O75874_AOU | AOU | n/a | 139582006 | n/a | (2E)-3-{3-[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbonyl]-1-methyl-1H-indol-7-yl}prop-2-enoic acid | n/a | |
| 18 | O75874_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 19 | O75874_C81 | C81 | n/a | 90415637 | CHEMBL3947537 | (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one | n/a | |
| 20 | O75874_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 21 | O75874_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 22 | O75874_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 23 | O75874_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 24 | O75874_DWG | DWG | n/a | 118291647 | CHEMBL4551778 | (6aS,7S,9S,10aS)-7-methyl-8-oxo-10a-phenyl-2-(phenylamino)-5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazoline-9-carbonitrile | n/a | |
| 25 | O75874_DWJ | DWJ | n/a | 137349209 | n/a | (5aS,6S,8S,9aS)-2-(benzenecarbonyl)-6-methyl-7-oxo-9a-phenyl-4,5,5a,6,7,8,9,9a-octahydro-2H-benzo[g]indazole-8-carbonitrile | n/a | |
| 26 | O75874_DWM | DWM | n/a | 134693801 | CHEMBL4515358 | (7R)-1-[(4-fluorophenyl)methyl]-N-{3-[(1R)-1-hydroxyethyl]phenyl}-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide | n/a | |
| 27 | O75874_DWP | DWP | n/a | 134693800 | n/a | (6aS,7S,9R,10aS)-7,10a-dimethyl-8-oxo-2-(phenylamino)-5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazoline-9-carbonitrile | n/a | |
| 28 | O75874_DWS | DWS | n/a | 134693805 | n/a | 3-[(6aS,7S,9S,10aS)-9-cyano-7-methyl-8-oxo-2-(phenylamino)-6,6a,7,8,9,10-hexahydrobenzo[h]quinazolin-10a(5H)-yl]benzoic acid | n/a | |
| 29 | O75874_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 30 | O75874_FLC | FLC | n/a | 31348 | n/a | CITRATE ANION | n/a | |
| 31 | O75874_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 32 | O75874_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 33 | O75874_HJQ | HJQ | n/a | 86567576 | n/a | (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine | n/a | |
| 34 | O75874_ICT | ICT | n/a | 5318532 | CHEMBL390356 | ISOCITRIC ACID | n/a | |
| 35 | O75874_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 36 | O75874_K32 | K32 | n/a | 10389037 | CHEMBL221360 | 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-ONE | n/a | |
| 37 | O75874_LJV | LJV | n/a | 118956132 | CHEMBL4472519 | 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile | n/a | |
| 38 | O75874_LJY | LJY | n/a | 118955625 | CHEMBL4440107 | 4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methoxybenzonitrile | n/a | |
| 39 | O75874_LMR | LMR | n/a | 222656;138628585; | CHEMBL1234046 | (2S)-2-hydroxybutanedioic acid | n/a | |
| 40 | O75874_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 41 | O75874_MLA | MLA | DB02175 | 867;23511544; | CHEMBL7942 | MALONIC ACID | n/a | |
| 42 | O75874_MLT | MLT | DB03499 | 92824 | CHEMBL225986 | D-MALATE | n/a | |
| 43 | O75874_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 44 | O75874_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 45 | O75874_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 46 | O75874_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 47 | O75874_PWV | PWV | DB16267 | 118955396 | CHEMBL4297610 | 5-{[(1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile | inhibitor | |
| 48 | O75874_QD8 | QD8 | n/a | 165416421 | n/a | (S)-3-butyl-2-oxopentanedioic acid | n/a | |
| 49 | O75874_QDC | QDC | n/a | 165416420 | n/a | (R)-3-butyl-2-oxopentanedioic acid | n/a | |
| 50 | O75874_QWM | QWM | n/a | 117817076 | CHEMBL4278828 | N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | n/a | |
| 51 | O75874_R1R | R1R | n/a | n/a | n/a | [2-[2-[[1-[4-[(1S)-1-[[5-fluoranyl-4-[(4S)-2-oxidanylidene-4-propan-2-yl-1,3-oxazolidin-3-yl]pyrimidin-2-yl]amino]ethyl]phenyl]piperidin-4-yl]sulfamoyl]ethylsulfanylmethyl]-3-oxidanylidene-propyl]-trimethyl-azanium | n/a | |
| 52 | O75874_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 53 | O75874_VVS | VVS | n/a | 73427242 | CHEMBL4208002 | 2,6-bis(1H-imidazol-1-ylmethyl)-4-(2,4,4-trimethylpentan-2-yl)phenol | n/a | |
| 54 | O75874_N81 | N81 | DB01727 | 447805 | n/a | Isocitric Acid | n/a | |
| 55 | O75874_DB14568 | n/a | DB14568 | n/a | n/a | Ivosidenib | inhibitor |