Gene name: PDE5A
Protein name: cGMP-specific 3',5'-cyclic phosphodiesterase
List of molecules and drugs that interact with protein O76074
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O76074_0H3 | 0H3 | n/a | 56587955 | CHEMBL1916290 | 7-(6-methoxypyridin-3-yl)-4-{[2-(propan-2-yloxy)ethyl]amino}-1-(2-propoxyethyl)pyrido[4,3-d]pyrimidin-2(1H)-one | n/a | |
| 2 | O76074_24E | 24E | n/a | 71765666 | CHEMBL4210889 | 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one | n/a | |
| 3 | O76074_2OI | 2OI | n/a | 163321745 | n/a | 2-[(4-chlorophenyl)methyl]-5-methoxy-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one | n/a | |
| 4 | O76074_2VI | 2VI | n/a | 163321746 | n/a | 5-[bis(fluoranyl)methoxy]-2-[(4-chlorophenyl)methyl]-10-(3-methoxypropyl)-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one | n/a | |
| 5 | O76074_3P4 | 3P4 | n/a | 11840908;135431464; | n/a | 5-[2-(BUT-3-EN-1-YLOXY)-5-(1-HYDROXYVINYL)PYRIDIN-3-YL]-3-ETHYL-2-(1-ETHYLAZETIDIN-3-YL)-1,2,6,7A-TETRAHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | n/a | |
| 6 | O76074_5BA | 5BA | n/a | 58538460;135566795; | CHEMBL2414314 | 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one | n/a | |
| 7 | O76074_5BB | 5BB | n/a | 67454187;135566796; | CHEMBL2414304 | 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one | n/a | |
| 8 | O76074_5BO | 5BO | n/a | 53338888;135566576; | CHEMBL1915519 | 5-bromo-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | n/a | |
| 9 | O76074_5CO | 5CO | n/a | 46836127;135566575; | CHEMBL1915518 | 5-chloro-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | n/a | |
| 10 | O76074_5EO | 5EO | n/a | 57392124;135566907; | CHEMBL1915516 | 6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | n/a | |
| 11 | O76074_5FO | 5FO | n/a | 46836318;135566574; | CHEMBL1915517 | 6-ethyl-5-fluoro-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | n/a | |
| 12 | O76074_5GP | 5GP | DB01972 | 6804;5280325;135398631; | CHEMBL283807 | GUANOSINE-5'-MONOPHOSPHATE | inhibitor | |
| 13 | O76074_5IO | 5IO | n/a | 46836131;135566906; | CHEMBL1915520 | 6-ethyl-5-iodo-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | n/a | |
| 14 | O76074_6LK | 6LK | n/a | 70355030 | n/a | 1-(5-chloro-6-methoxypyridin-3-yl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide | n/a | |
| 15 | O76074_7CA | 7CA | n/a | 6852214 | n/a | 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE | n/a | |
| 16 | O76074_9M0 | 9M0 | n/a | 134814217 | CHEMBL4206819 | 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one | n/a | |
| 17 | O76074_9T9 | 9T9 | n/a | 134814218 | n/a | 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-6-{[2-(4-methylpiperazin-1-yl)ethyl]amino}-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one | n/a | |
| 18 | O76074_AJR | AJR | n/a | 6918386 | CHEMBL80713 | 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol) | n/a | |
| 19 | O76074_B0C | B0C | n/a | 58538303;136197286; | CHEMBL4462192 | N-[3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide | n/a | |
| 20 | O76074_CIA | CIA | DB00820 | 110635 | CHEMBL779 | 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE | inhibitor | Ki(nM) = 5.2 IC50(nM) = 1.2 EC50(nM) = 5810.0 |
| 21 | O76074_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 22 | O76074_E6L | E6L | DB06237 | 9869929 | CHEMBL1963681 | 4-[(3-chloranyl-4-methoxy-phenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimid ine-5-carboxamide | inhibitor | Ki(nM) = 5.0 IC50(nM) = 5200.0 |
| 23 | O76074_FZA | FZA | n/a | 155804436 | CHEMBL4794748 | (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one | n/a | |
| 24 | O76074_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | O76074_IBM | IBM | DB07954 | 3758 | CHEMBL275084 | 3-ISOBUTYL-1-METHYLXANTHINE | inhibitor | Ki(nM) = 8500.0 IC50(nM) = 2100.0 |
| 26 | O76074_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 27 | O76074_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 28 | O76074_NI0 | NI0 | n/a | 46836255;135566745; | CHEMBL2180945 | 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one | n/a | |
| 29 | O76074_NI5 | NI5 | n/a | 71455605;135566746; | CHEMBL2180955 | 2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one | n/a | |
| 30 | O76074_PD4 | PD4 | n/a | 42628078 | CHEMBL564374 | 6-(6-methoxypyridin-3-yl)-2-[(2-morpholin-4-ylethyl)amino]-4-(2-propoxyethyl)pyrido[2,3-b]pyrazin-3(4H)-one | n/a | |
| 31 | O76074_PD6 | PD6 | n/a | 42628079 | n/a | 5-amino-1-butyl-7-phenyl-1,6-naphthyridin-4(1H)-one | n/a | |
| 32 | O76074_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 33 | O76074_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 34 | O76074_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 35 | O76074_TGE | TGE | n/a | 11993169 | CHEMBL551052 | 7-(6-methoxypyridin-3-yl)-3-{[2-(morpholin-4-yl)ethyl]amino}-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one | n/a | |
| 36 | O76074_VDN | VDN | DB00862 | 110634;135400189; | CHEMBL1520 | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE | inhibitor | Ki(nM) = 0.7 IC50(nM) = 0.029 |
| 37 | O76074_VIA | VIA | DB00203 | 5212;5281023;135398744; | CHEMBL192 | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | inhibitor | |
| 38 | O76074_VZF | VZF | n/a | 169410463 | n/a | 2-[bis(2-hydroxyethyl)amino]-6-[(4-methoxyphenyl)methylamino]-9-propan-2-yl-7~{H}-purin-8-one | n/a | |
| 39 | O76074_WAN | WAN | DB08729 | 24771758;135566412; | CHEMBL1236703 | 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide | n/a | |
| 40 | O76074_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 41 | O76074_TEP | TEP | DB00277 | 2153 | CHEMBL190 | Theophylline | inhibitor | |
| 42 | O76074_H9F | H9F | DB00975 | 3108 | CHEMBL932 | Dipyridamole | inhibitor | IC50(nM) = 500.0 |
| 43 | O76074_G | G | DB01972 | 6804;5280325;135398631; | CHEMBL283807 | Guanosine-5'-Monophosphate | inhibitor | |
| 44 | O76074_IBG | IBG | DB03597 | 447108 | n/a | gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine | inhibitor | |
| 45 | O76074_SLO | SLO | DB06246 | 5472495 | CHEMBL488025 | Exisulind | modulator | |
| 46 | O76074_DB06267 | n/a | DB06267 | n/a | n/a | Udenafil | inhibitor | |
| 47 | O76074_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |