Gene name: PDE9A
Protein name: High affinity cGMP-specific
List of molecules and drugs that interact with protein O76083
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O76083_06A | 06A | n/a | 163183770 | CHEMBL5075032 | 1-cyclopentyl-6-[[(2R)-1-(6-fluoranyl-2-azaspiro[3.3]heptan-2-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 2 | O76083_0WF | 0WF | n/a | 135566743 | CHEMBL2180072 | 1-cyclopentyl-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 3 | O76083_0WL | 0WL | n/a | 135566744 | CHEMBL2180070 | 1-cyclopentyl-6-{(1R)-1-[3-(pyrimidin-2-yl)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 4 | O76083_49D | 49D | n/a | 135567003 | CHEMBL5285855 | 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 5 | O76083_49E | 49E | n/a | 135567004 | CHEMBL4644938 | 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 6 | O76083_5GP | 5GP | DB01972 | 6804;5280325;135398631; | CHEMBL283807 | GUANOSINE-5'-MONOPHOSPHATE | n/a | |
| 7 | O76083_7RG | 7RG | DB11953 | 135564558 | CHEMBL2179105 | 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | inhibitor | |
| 8 | O76083_9Q9 | 9Q9 | n/a | 137700754 | CHEMBL4580164 | 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 9 | O76083_BYE | BYE | n/a | 135566505 | CHEMBL4636079 | 1-(2-chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 10 | O76083_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 11 | O76083_EZU | EZU | n/a | 155801588 | n/a | 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 12 | O76083_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 13 | O76083_IBM | IBM | DB07954 | 3758 | CHEMBL275084 | 3-ISOBUTYL-1-METHYLXANTHINE | n/a | IC50(nM) = 117000.0 |
| 14 | O76083_JAR | JAR | n/a | 135566501 | CHEMBL572517 | 6-[(3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(1-methylethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 15 | O76083_LUO | LUO | n/a | 135566753 | n/a | N-(4-methoxyphenyl)-N~2~-[1-(2-methylphenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-L-alaninamide | n/a | |
| 16 | O76083_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 17 | O76083_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 18 | O76083_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 19 | O76083_PCG | PCG | DB02315 | 24316;5280386;135398570; | CHEMBL395336 | CYCLIC GUANOSINE MONOPHOSPHATE | n/a | |
| 20 | O76083_R4I | R4I | n/a | 166449483 | n/a | (8~{S})-6-[2-(2,3-dihydroindol-1-yl)-2-oxidanylidene-ethyl]-4-(4-methylphenyl)-2-oxidanylidene-8-propyl-1,5,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile | n/a | |
| 21 | O76083_WTC | WTC | n/a | 135566500 | CHEMBL572934 | 6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 22 | O76083_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 23 | O76083_IBG | IBG | DB03597 | 447108 | n/a | gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine | n/a |