Gene name: Dhfr
Protein name: Dihydrofolate reductase (EC
List of molecules and drugs that interact with protein P00375
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P00375_51P | 51P | n/a | 11687971 | CHEMBL606039 | 5-[(1Z)-2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | n/a | |
| 2 | P00375_D09 | D09 | n/a | 6477203 | CHEMBL610181 | 5-[(1E)-2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine | n/a | |
| 3 | P00375_DH3 | DH3 | n/a | 5271440 | CHEMBL300419 | 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE | n/a | |
| 4 | P00375_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 5 | P00375_MTX | MTX | DB00563 | 126941 | CHEMBL34259 | METHOTREXATE | n/a | Ki(nM) = 0.0 IC50(nM) = 6.6 |
| 6 | P00375_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 7 | P00375_Q22 | Q22 | DB08448 | 46937152 | n/a | (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol | n/a |