Gene name: thyA
Protein name: Thymidylate synthase (TS)
List of molecules and drugs that interact with protein P00469
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P00469_14C | 14C | DB06860 | 25134265 | CHEMBL1229651 | 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione | n/a | Ki(nM) = 23000.0 |
| 2 | P00469_15C | 15C | n/a | 46840165 | CHEMBL1229661 | 2-(4-acetylphenyl)-4-methyl-1H-isoindole-1,3(2H)-dione | n/a | |
| 3 | P00469_20C | 20C | n/a | 46840167 | CHEMBL1229792 | 2-hydroxy-4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid | n/a | |
| 4 | P00469_7C1 | 7C1 | n/a | n/a | CHEMBL1230558 | 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenecarboximidamide | n/a | |
| 5 | P00469_A15 | A15 | n/a | 448780 | CHEMBL67116 | 3'-3"-DICHLOROPHENOL-1,8-3H-BENZO[DE]ISOCHROMEN-1-ONE | n/a | |
| 6 | P00469_C00 | C00 | DB07507 | 25134257 | CHEMBL1231545 | 2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione | n/a | Ki(nM) = 3000.0 |
| 7 | P00469_C16 | C16 | DB07511 | 25113145 | CHEMBL1231557 | 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile | n/a | Ki(nM) = 22000.0 |
| 8 | P00469_CB3 | CB3 | DB03541 | 443388;5281971;135438608; | CHEMBL389051 | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | n/a | |
| 9 | P00469_DCM | DCM | DB03798 | 13945 | CHEMBL374699 | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE | n/a | |
| 10 | P00469_DHF | DHF | DB02015 | 98792;5280349;135398604; | CHEMBL46294 | DIHYDROFOLIC ACID | n/a | |
| 11 | P00469_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 12 | P00469_MR2 | MR2 | DB08204 | 448781 | CHEMBL303950 | 3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE | n/a | |
| 13 | P00469_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 14 | P00469_THF | THF | DB02800 | 5289464;6323516;135403828; | n/a | 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID | n/a | |
| 15 | P00469_TMF | TMF | DB02301 | 5289479;6323520;135403830; | n/a | 5,10-METHYLENE-6-HYDROFOLIC ACID | n/a | |
| 16 | P00469_TMP | TMP | DB01643 | 9700 | CHEMBL394429 | THYMIDINE-5'-PHOSPHATE | product of | Ki(nM) = 8690.0 |
| 17 | P00469_U5P | U5P | DB03685 | 6030 | CHEMBL214393 | URIDINE-5'-MONOPHOSPHATE | n/a | |
| 18 | P00469_UFP | UFP | DB03761 | 8642 | CHEMBL886 | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | n/a | |
| 19 | P00469_UMP | UMP | DB03800 | 65063 | CHEMBL211312 | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | n/a | Ki(nM) = 2260.0 |