Gene name: PNP
Protein name: Purine nucleoside phosphorylase
List of molecules and drugs that interact with protein P00491
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P00491_229 | 229 | n/a | 16724046;135566506; | CHEMBL475537 | 7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE | n/a | |
| 2 | P00491_22A | 22A | n/a | 16724166;135723758; | CHEMBL505564 | 7-({[2-hydroxy-1-(hydroxymethyl)ethyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | n/a | |
| 3 | P00491_2DI | 2DI | DB00900 | 50599;5273537;135398739; | CHEMBL1460 | 9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE | substrate | |
| 4 | P00491_2FD | 2FD | DB02947 | 447864 | CHEMBL1229920 | 5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL | n/a | |
| 5 | P00491_3DG | 3DG | DB03609 | 165138;5287497;135440068; | CHEMBL73502 | 9-(3-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE | inhibitor | |
| 6 | P00491_7DG | 7DG | DB02245 | 4470573;5287552;135497479; | CHEMBL219544 | 7-DEAZAGUANINE | n/a | |
| 7 | P00491_A2F | A2F | n/a | 12790 | CHEMBL580404 | 2-fluoroadenine | n/a | |
| 8 | P00491_AC2 | AC2 | DB00787 | 2022;5280999;135398513; | CHEMBL184 | 9-HYROXYETHOXYMETHYLGUANINE | n/a | |
| 9 | P00491_AZG | AZG | DB01667 | 8646;135403646; | CHEMBL374107 | 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL | inhibitor | |
| 10 | P00491_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 11 | P00491_D1V | D1V | n/a | 83804;683940; | CHEMBL1232053 | 2-mercapto(3H)quinazolinone | n/a | |
| 12 | P00491_DIH | DIH | DB03551 | 44629480;135927341; | n/a | 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one | n/a | |
| 13 | P00491_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 14 | P00491_GMP | GMP | DB02857 | 6802;5274256;135398635; | CHEMBL375655 | GUANOSINE | inhibitor | |
| 15 | P00491_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 16 | P00491_GUN | GUN | DB02377 | 764;5274253;135398634; | CHEMBL219568 | GUANINE | n/a | |
| 17 | P00491_IM5 | IM5 | n/a | 10171607;135415984; | CHEMBL475750 | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | n/a | |
| 18 | P00491_IMH | IMH | DB06185 | 444499;5288627;135409409; | CHEMBL218291 | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL | inhibitor | |
| 19 | P00491_JSI | JSI | n/a | 156316540 | CHEMBL5499373 | [(~{E})-2-[5-bromanyl-2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenyl]ethenyl]phosphonic acid | n/a | |
| 20 | P00491_JT3 | JT3 | n/a | 168059294 | CHEMBL5500028 | [(~{E})-2-[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]-6-[2,3,4,5,6-pentakis(fluoranyl)phenoxy]phenyl]ethenyl]phosphonic acid | n/a | |
| 21 | P00491_JTC | JTC | n/a | 156316535 | CHEMBL5499212 | [(~{E})-2-[2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]-5-[2,3,4,5,6-pentakis(fluoranyl)phenoxy]phenyl]ethenyl]phosphonic acid | n/a | |
| 22 | P00491_JTO | JTO | n/a | 161351852 | CHEMBL5499996 | [2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic acid | n/a | |
| 23 | P00491_JU9 | JU9 | n/a | 159155854 | CHEMBL5499224 | [(~{E})-2-[4-methoxy-2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenyl]ethenyl]phosphonic acid | n/a | |
| 24 | P00491_MSG | MSG | n/a | 5494430 | CHEMBL1234483 | 7-METHYL-6-THIO-GUANOSINE | n/a | |
| 25 | P00491_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 26 | P00491_NOS | NOS | DB04335 | 6021;5274258;135398641; | CHEMBL1556 | INOSINE | n/a | |
| 27 | P00491_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 28 | P00491_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 29 | P00491_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 30 | P00491_TEW | TEW | n/a | n/a | n/a | 6-tungstotellurate(VI) | n/a | |
| 31 | P00491_CL9 | CL9 | DB00242 | 20279 | CHEMBL1619 | Cladribine | inducer | |
| 32 | P00491_9PP | 9PP | DB02222 | 5287571 | n/a | 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine | n/a | |
| 33 | P00491_IMG | IMG | DB02230 | 444498;5288626;135445969; | CHEMBL473922 | Immucillin-G | inhibitor | |
| 34 | P00491_GU7 | GU7 | DB02391 | 445732;135488878; | n/a | 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One | n/a | |
| 35 | P00491_BC3 | BC3 | DB02568 | 60817;135413525; | CHEMBL311300 | Peldesine | inhibitor | |
| 36 | P00491_9DI | 9DI | DB02796 | 122671;5287567;135483765; | n/a | 9-deazainosine | inhibitor | |
| 37 | P00491_R1P | R1P | DB03101 | 439236 | CHEMBL603367 | Ribose-1-Phosphate | inhibitor | |
| 38 | P00491_MTI | MTI | DB03881 | 5288855;6323421;131704261;135509130;135678090; | n/a | (2S,3R,4S,5S)-3,4-Dihydroxy-2-[(methylsulfanyl)methyl]-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidinium | n/a | |
| 39 | P00491_HPA | HPA | DB04076 | 790;5274269;135398638; | CHEMBL1427 | Hypoxanthine | inhibitor | |
| 40 | P00491_HA1 | HA1 | DB04260 | 448999;5288506;135460987; | CHEMBL236708 | 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine | inhibitor | Ki(nM) = 10.8 IC50(nM) = 20.2 |
| 41 | P00491_P1D | P1D | DB04753 | 5289092;5327013;135464487; | n/a | 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE | inhibitor | |
| 42 | P00491_P1G | P1G | DB04754 | 5289093;5327012;135464486; | n/a | GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE | inhibitor | |
| 43 | P00491_P2G | P2G | DB04757 | 5289094;5327014;135464488; | n/a | GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE | inhibitor |