Gene name: PRKACA
Protein name: cAMP-dependent protein kinase
List of molecules and drugs that interact with protein P00517
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P00517_0RW | 0RW | n/a | 820804 | CHEMBL1762732 | 3-methyl-2H-indazole | n/a | |
| 2 | P00517_15I | 15I | n/a | 70789255 | CHEMBL2420911 | 6-(2,9-Diazaspiro[5.5]undecan-9-yl)-9H-purine | n/a | |
| 3 | P00517_2EA | 2EA | DB06959 | 11840906 | n/a | (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE | n/a | |
| 4 | P00517_2PY | 2PY | DB06977 | 49866474 | n/a | (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE | n/a | |
| 5 | P00517_4EA | 4EA | DB07107 | 6914613 | CHEMBL383541 | (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE | n/a | IC50(nM) = 38.0 |
| 6 | P00517_4L7 | 4L7 | n/a | 118986993;135566977; | n/a | 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one | n/a | |
| 7 | P00517_4PY | 4PY | DB07124 | 46937052 | n/a | (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | n/a | |
| 8 | P00517_6EA | 6EA | DB07204 | 6914614 | CHEMBL207496 | (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE | n/a | |
| 9 | P00517_9CY | 9CY | n/a | 68513305 | CHEMBL4467869 | N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-4-(pyridin-4-yl)benzamide | n/a | |
| 10 | P00517_9D1 | 9D1 | n/a | 44253315 | n/a | 3-({[6-(pyridin-4-yl)-1,3-benzothiazol-2-yl][2-(pyrrolidin-1-yl)ethyl]amino}methyl)phenol | n/a | |
| 11 | P00517_9D4 | 9D4 | n/a | 44252286 | n/a | N-[(3-fluorophenyl)methyl]-6-(pyridin-4-yl)-1,3-benzothiazol-2-amine | n/a | |
| 12 | P00517_A02 | A02 | n/a | 25190767 | CHEMBL297394 | (10R,20R,23R)-10-(4-aminobutyl)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamidopropyl)-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide | n/a | |
| 13 | P00517_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 14 | P00517_ARX | ARX | n/a | 25141061 | CHEMBL450179 | (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-(6-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}butyl]amino}-6-oxohexyl)-3,4-dihydroxytetrahydrofuran-2-carboxamide | n/a | |
| 15 | P00517_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 16 | P00517_BI4 | BI4 | DB07458 | 448642 | n/a | 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE | n/a | |
| 17 | P00517_BU3 | BU3 | n/a | 225936 | n/a | (R,R)-2,3-BUTANEDIOL | n/a | |
| 18 | P00517_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 19 | P00517_CQP | CQP | DB07583 | 5327110 | n/a | (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE | n/a | IC50(nM) = 400.0 |
| 20 | P00517_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 21 | P00517_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | P00517_EMU | EMU | n/a | 62389 | CHEMBL228862 | N-BENZYL-9H-PURIN-6-AMINE | n/a | |
| 23 | P00517_G96 | G96 | n/a | 11857236 | CHEMBL1098938 | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | n/a | |
| 24 | P00517_G98 | G98 | n/a | n/a | n/a | 4-[2-(4-amino-2,5-dihydro-1,2,5-oxadiazol-3-yl)-6-{[(1S)-3-amino-1-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | n/a | |
| 25 | P00517_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 26 | P00517_GVG | GVG | n/a | 139601 | CHEMBL228114 | 3-METHYL-4-PHENYL-1H-PYRAZOLE | n/a | |
| 27 | P00517_GVH | GVH | n/a | 9222 | CHEMBL389685 | 1H-PYRROLO[2,3-B]PYRIDINE | n/a | |
| 28 | P00517_GVI | GVI | DB07854 | 11608401 | CHEMBL376388 | N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE | n/a | |
| 29 | P00517_GVJ | GVJ | DB07855 | 16122632 | n/a | (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE | n/a | |
| 30 | P00517_GVK | GVK | DB07856 | 16122633 | CHEMBL228133 | 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE | n/a | |
| 31 | P00517_GVN | GVN | DB07857 | 15602983 | CHEMBL227924 | (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE | n/a | |
| 32 | P00517_GVO | GVO | DB07858 | 15602982 | CHEMBL223339 | (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE | n/a | |
| 33 | P00517_GVP | GVP | DB07859 | 11175137 | CHEMBL428462 | 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE | n/a | |
| 34 | P00517_GVQ | GVQ | DB07860 | 16122635 | n/a | (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE | n/a | |
| 35 | P00517_H52 | H52 | DB07876 | 448043 | CHEMBL406821 | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE | n/a | IC50(nM) = 58.0 |
| 36 | P00517_I01 | I01 | n/a | 657001 | CHEMBL1233479 | (4R)-4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZOIC ACID (3R)-3-[(PYRIDINE-4-CARBONYL)AMINO]-AZEPAN-4-YL ESTER | n/a | |
| 37 | P00517_I04 | I04 | n/a | 657002 | CHEMBL1233481 | N-{(3R,4R)-4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZOYLAMINO]-AZEPAN-3-YL}ISONICOTINAMIDE | n/a | |
| 38 | P00517_I05 | I05 | n/a | 657016 | n/a | (3R,4R)-N-{4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZYLOXY]-AZEPAN-3-YL}-ISONICOTINAMIDE | n/a | |
| 39 | P00517_I08 | I08 | n/a | 657003 | CHEMBL283457 | (3R,4S)-N-(4-{TRANS-2-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-PHENYL]-VINYL}-AZEPAN-3-YL)-ISONICOTINAMIDE | n/a | |
| 40 | P00517_I5S | I5S | DB07947 | 5327109 | CHEMBL227381 | ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE | n/a | IC50(nM) = 170.0 |
| 41 | P00517_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 42 | P00517_IQB | IQB | DB07995 | 449241 | CHEMBL104264 | N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE | n/a | IC50(nM) = 73.0 |
| 43 | P00517_IQP | IQP | DB07996 | 449240 | CHEMBL1233654 | 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE | n/a | |
| 44 | P00517_IQS | IQS | DB07997 | 3540 | CHEMBL148333 | N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE | n/a | IC50(nM) = 5300.0 |
| 45 | P00517_J0G | J0G | n/a | 134823957 | CHEMBL4572198 | 2-[(2-aminoethyl)amino]-N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-(pyridin-4-yl)benzamide | n/a | |
| 46 | P00517_J0P | J0P | n/a | 134823958 | CHEMBL4522042 | N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide | n/a | |
| 47 | P00517_L15 | L15 | DB08070 | 16122634 | CHEMBL228224 | 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE | n/a | |
| 48 | P00517_L20 | L20 | DB08073 | 10172943 | CHEMBL379300 | (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | n/a | IC50(nM) = 6.0 |
| 49 | P00517_LL1 | LL1 | DB08113 | 12412578 | CHEMBL1234032 | 3-pyridin-4-yl-1H-indazole | n/a | |
| 50 | P00517_LL2 | LL2 | DB08114 | 691952 | CHEMBL1234033 | 5-benzyl-1,3-thiazol-2-amine | n/a | |
| 51 | P00517_M01 | M01 | n/a | 11708454 | CHEMBL259356 | 1-[1-(9H-purin-6-yl)piperidin-4-yl]methanamine | n/a | |
| 52 | P00517_M02 | M02 | n/a | 24701731 | CHEMBL261260 | 1-(9H-purin-6-yl)piperidin-4-amine | n/a | |
| 53 | P00517_M03 | M03 | DB08148 | 24762195 | CHEMBL406863 | 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine | n/a | |
| 54 | P00517_M04 | M04 | DB08149 | 11696113 | CHEMBL260000 | 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine | n/a | |
| 55 | P00517_M05 | M05 | DB08150 | 42627562 | n/a | 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium | n/a | |
| 56 | P00517_M77 | M77 | DB08162 | 3547 | CHEMBL38380 | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | n/a | IC50(nM) = 541.0 |
| 57 | P00517_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 58 | P00517_MG8 | MG8 | n/a | 4377671 | n/a | N-OCTANOYL-N-METHYLGLUCAMINE | n/a | |
| 59 | P00517_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 60 | P00517_MOH | MOH | n/a | 887 | CHEMBL14688 | METHANOL | n/a | |
| 61 | P00517_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 62 | P00517_MRD | MRD | n/a | 5288845 | n/a | (4R)-2-METHYLPENTANE-2,4-DIOL | n/a | |
| 63 | P00517_MYR | MYR | DB08231 | 11005 | CHEMBL111077 | MYRISTIC ACID | n/a | |
| 64 | P00517_NU3 | NU3 | n/a | 135546482 | CHEMBL131719 | 2-(4-hydroxyphenyl)-1H-benzimidazole-4-carboxamide | n/a | |
| 65 | P00517_NVX | NVX | n/a | 92132723;135566974; | n/a | 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one | n/a | |
| 66 | P00517_OCT | OCT | n/a | 356 | CHEMBL134886 | N-OCTANE | n/a | |
| 67 | P00517_PTV | PTV | n/a | 51362889 | n/a | 2-[[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-1-(2-thiophenyl)ethanone | n/a | |
| 68 | P00517_PZX | PZX | n/a | 47348247 | n/a | pyridin-3-ylmethyl 5-methyl-1H-pyrazole-3-carboxylate | n/a | |
| 69 | P00517_QNI | QNI | n/a | 70789256 | CHEMBL2420913 | 6-(2,9-DIAZASPIRO[5.5]UNDECAN-2-YL)-9H-PURINE | n/a | |
| 70 | P00517_QWI | QWI | n/a | 70789257 | n/a | 6-(4-PHENYL-1,9-DIAZASPIRO[5.5]UNDECAN-9-YL)-9H-PURINE | n/a | |
| 71 | P00517_R55 | R55 | n/a | 5289253 | CHEMBL1188712 | N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE | n/a | |
| 72 | P00517_R68 | R68 | n/a | 5289254 | n/a | N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE | n/a | |
| 73 | P00517_R69 | R69 | n/a | 5289255 | CHEMBL1188538 | N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE | n/a | |
| 74 | P00517_R94 | R94 | n/a | 5289256 | CHEMBL1195612 | N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE | n/a | |
| 75 | P00517_R96 | R96 | n/a | 5289257 | CHEMBL1188031 | N-[4-({4-[5-(3,3-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE | n/a | |
| 76 | P00517_RKD | RKD | n/a | 57519715 | n/a | (2S)-2-(4-chlorophenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)phenyl]ethanaminium | n/a | |
| 77 | P00517_SIJ | SIJ | n/a | 70789254 | CHEMBL2420909 | 6-(1,9-DIAZASPIRO[5.5]UNDECAN-9-YL)-9H-PURINE | n/a | |
| 78 | P00517_VUP | VUP | n/a | 71737819 | n/a | 4-(1-ethyl-6-methyl-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine | n/a | |
| 79 | P00517_Y27 | Y27 | DB08756 | n/a | CHEMBL559147 | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | n/a | IC50(nM) = 6000.0 |
| 80 | P00517_Z21 | Z21 | n/a | 16099851 | n/a | 4-(6-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine | n/a | |
| 81 | P00517_ZO9 | ZO9 | n/a | 607858 | CHEMBL1078930 | 4-[1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine | n/a | |
| 82 | P00517_SS3 | SS3 | DB08568 | 11314340 | CHEMBL379218 | (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE | n/a | Ki(nM) = 16.0 IC50(nM) = 16.0 |
| 83 | P00517_SS4 | SS4 | DB08569 | 16122642 | CHEMBL229855 | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE | n/a | IC50(nM) = 15.0 |
| 84 | P00517_SS5 | SS5 | n/a | 16122641 | CHEMBL226796 | (2S)-1-[3-(CYCLOHEXYLMETHOXY)PHENYL]-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | n/a | |
| 85 | P00517_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a |