Gene name: ABL1
Protein name: Tyrosine-protein kinase ABL1
List of molecules and drugs that interact with protein P00519
# | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
---|---|---|---|---|---|---|---|---|
1 | P00519_112 | 112 | n/a | 5287416 | n/a | THIOPHOSPHORIC ACID O-((ADENOSYL-PHOSPHO)PHOSPHO)-S-ACETAMIDYL-DIESTER | n/a | |
2 | P00519_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | inhibitor | IC50(nM) = 0.138 Kd(nM) = 0.016 EC50(nM) = 0.04 |
3 | P00519_2PE | 2PE | n/a | 4867 | n/a | NONAETHYLENE GLYCOL | n/a | |
4 | P00519_406 | 406 | DB11851 | 11387605 | CHEMBL206834 | N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-4-{[(3S)-3-(DIMETHYLAMINO)PYRROLIDIN-1-YL]METHYL}-3-(TRIFLUOROMETHYL) BENZAMIDE | n/a | |
5 | P00519_4B7 | 4B7 | n/a | 118704885 | n/a | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide | n/a | |
6 | P00519_4ST | 4ST | n/a | 4369398 | n/a | 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE | n/a | |
7 | P00519_627 | 627 | DB11778 | 11442891 | CHEMBL402548 | N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE | n/a | |
8 | P00519_66K | 66K | n/a | 121232411 | CHEMBL3963223 | 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | n/a | |
9 | P00519_7MP | 7MP | n/a | 9547982 | n/a | 7-AMINO-1-METHYL-3-(2-METHYL-5-{[3-(TRIFLUOROMETHYL)BENZOYL]AMINO}PHENYL)-2-OXO-2,3-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-1-IUM | n/a | |
10 | P00519_8DW | 8DW | n/a | 163196949 | n/a | 5-[5-(dimethylcarbamoyl)pyridin-3-yl]-3-(5-fluorosulfonyloxy-2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine | n/a | |
11 | P00519_8IW | 8IW | n/a | 163321758 | n/a | 5-[3-(5-methanoyl-2-methoxy-4-oxidanyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-~{N},~{N}-dimethyl-pyridine-3-carboxamide | n/a | |
12 | P00519_919 | 919 | DB13005 | 25066467 | CHEMBL1738757 | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide | modulator | |
13 | P00519_9DP | 9DP | n/a | 11854202;72200433; | n/a | (3S)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | n/a | |
14 | P00519_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
15 | P00519_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
16 | P00519_AXI | AXI | DB06626 | 6450551 | CHEMBL1289926 | AXITINIB | inhibitor | |
17 | P00519_AY7 | AY7 | DB12597 | 72165228 | CHEMBL4208229 | asciminib | inhibitor | |
18 | P00519_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
19 | P00519_DB8 | DB8 | DB06616 | 5328940 | CHEMBL288441 | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | inhibitor | IC50(nM) = 0.5 Kd(nM) = 0.029 |
20 | P00519_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
21 | P00519_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
22 | P00519_FVC | FVC | n/a | 155923698 | n/a | [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]boronic acid | n/a | |
23 | P00519_GIN | GIN | DB07831 | 10477723 | n/a | 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE | n/a | |
24 | P00519_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
25 | P00519_HJ9 | HJ9 | n/a | 155923705 | n/a | [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methanoyl-5-methoxy-phenyl]boronic acid | n/a | |
26 | P00519_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
27 | P00519_JIN | JIN | n/a | 5311104 | CHEMBL574058 | 6-(2,6-DICHLOROPHENYL)-2-[(4-FLUORO-3-METHYLPHENYL)AMINO]-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | n/a | |
28 | P00519_KWD | KWD | n/a | 2118106 | CHEMBL4562851 | 2-cyano-~{N}-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]ethanamide | n/a | |
29 | P00519_KWP | KWP | n/a | 138753299 | n/a | ~{N}-[(4~{S})-2-(3,4-dichlorophenyl)-4-(2-hydroxyethyl)-3,4-dihydropyrazol-5-yl]pyridine-4-carboxamide | n/a | |
30 | P00519_KWV | KWV | n/a | 138753300 | CHEMBL4471351 | ~{N}-[2-(3,4-dichlorophenyl)-3,4-dihydropyrazol-5-yl]ethanamide | n/a | |
31 | P00519_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
32 | P00519_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
33 | P00519_MXE | MXE | DB02806 | 8019 | CHEMBL444144 | 2-METHOXYETHANOL | n/a | |
34 | P00519_MYR | MYR | DB08231 | 11005 | CHEMBL111077 | MYRISTIC ACID | inhibitor | |
35 | P00519_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
36 | P00519_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
37 | P00519_NIL | NIL | DB04868 | 644241 | CHEMBL255863 | Nilotinib | inhibitor | Ki(nM) = 1.0 IC50(nM) = 0.33 Kd(nM) = 3.6 |
38 | P00519_P16 | P16 | DB08339 | 447700 | CHEMBL327127 | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | inhibitor | IC50(nM) = 2.8 |
39 | P00519_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
40 | P00519_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
41 | P00519_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
42 | P00519_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
43 | P00519_PVB | PVB | DB02733 | 448991 | CHEMBL23254 | PURVALANOL B | n/a | |
44 | P00519_QEW | QEW | n/a | 166625068 | n/a | 1-[6-(6-methoxyisoquinolin-7-yl)-1,3-benzothiazol-2-yl]-3-(2-oxidanylideneethyl)urea | n/a | |
45 | P00519_QH9 | QH9 | n/a | 167311808 | n/a | 5-[3-(6-methoxyisoquinolin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-methyl-N-prop-2-ynyl-pyridine-3-carboxamide | n/a | |
46 | P00519_SKI | SKI | n/a | 1474853 | CHEMBL97771 | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine | n/a | |
47 | P00519_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
48 | P00519_VX6 | VX6 | n/a | 5494449 | CHEMBL572878 | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | n/a | |
49 | P00519_STI | STI | DB00619 | 5291 | CHEMBL941 | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | inhibitor | Ki(nM) = 13.0 IC50(nM) = 1.1 Kd(nM) = 1.0 EC50(nM) = 34.0 |
50 | P00519_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ATP | inhibitor | |
51 | P00519_PRC | PRC | DB03878 | 4327 | n/a | N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide | n/a | |
52 | P00519_KIN | KIN | DB08043 | 15942672 | CHEMBL1233853 | 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA | n/a | |
53 | P00519_P3Y | P3Y | DB08350 | 16750094 | CHEMBL1235103 | 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE | n/a | Ki(nM) = 20.0 IC50(nM) = 9.0 |
54 | P00519_SX7 | SX7 | DB08583 | 135566433 | n/a | 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide | n/a | |
55 | P00519_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | IC50(nM) = 500.0 |
56 | P00519_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | Ponatinib | inhibitor | IC50(nM) = 0.3 Kd(nM) = 0.7 EC50(nM) = 0.05 |
57 | P00519_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
58 | P00519_6GY | 6GY | DB12267 | 68165256 | CHEMBL3545311 | Brigatinib | inhibitor | |
59 | P00519_DB12323 | n/a | DB12323 | n/a | n/a | Radotinib | antagonist | |
60 | P00519_DB14989 | n/a | DB14989 | n/a | n/a | Umbralisib | inhibitor |