Gene name: SRC
Protein name: Proto-oncogene tyrosine-protein kinase
List of molecules and drugs that interact with protein P00523
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P00523_0JN | 0JN | n/a | 5154691 | CHEMBL573578 | 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 2 | P00523_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | n/a | IC50(nM) = 0.9 Kd(nM) = 0.7 |
| 3 | P00523_0UL | 0UL | n/a | 71463564 | n/a | 6-phenyl[1,2,4]triazolo[1,5-a]pyrazin-2-amine | n/a | |
| 4 | P00523_11V | 11V | n/a | 90657091 | CHEMBL3393979 | 1-[(2R)-2-chloro-2-phenylethyl]-6-{[2-(morpholin-4-yl)ethyl]sulfanyl}-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 5 | P00523_1AU | 1AU | DB06882 | 25174101 | CHEMBL522387 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea | n/a | IC50(nM) = 64100.0 |
| 6 | P00523_1AW | 1AW | DB06883 | 10915062 | CHEMBL87580 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea | n/a | |
| 7 | P00523_1BU | 1BU | n/a | 42601396 | CHEMBL497033 | 1-{4-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea | n/a | |
| 8 | P00523_1E8 | 1E8 | DB09053 | 24821094 | CHEMBL1873475 | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | n/a | |
| 9 | P00523_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | n/a | IC50(nM) = 0.4 Kd(nM) = 0.07 |
| 10 | P00523_29K | 29K | n/a | 71816192 | n/a | (7S)-12-(4-aminobutyl)-7-(2-methylpropyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one | n/a | |
| 11 | P00523_37O | 37O | n/a | 121426117 | n/a | N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide | n/a | |
| 12 | P00523_4A9 | 4A9 | n/a | 118704883 | n/a | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(3-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 13 | P00523_4B7 | 4B7 | n/a | 118704885 | n/a | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide | n/a | |
| 14 | P00523_563 | 563 | n/a | 68342470 | CHEMBL3604922 | N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide | n/a | |
| 15 | P00523_56G | 56G | n/a | 122186141 | CHEMBL3604921 | N-[3-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide | n/a | |
| 16 | P00523_6G3 | 6G3 | n/a | 60196244 | CHEMBL4471573 | N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea | n/a | |
| 17 | P00523_71D | 71D | n/a | 137348550 | n/a | (2R)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanami de | n/a | |
| 18 | P00523_72F | 72F | n/a | 137348553 | n/a | N-[3-({6-[(2S)-2-cyano-3-(methylamino)-3-oxopropyl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide | n/a | |
| 19 | P00523_73A | 73A | n/a | 129626280 | n/a | (2E)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)prop-2-enamide | n/a | |
| 20 | P00523_8BU | 8BU | n/a | 132274771 | n/a | [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid | n/a | |
| 21 | P00523_8C6 | 8C6 | n/a | 129900218 | n/a | [(R)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]-chloranyl-methyl]phosphonic acid | n/a | |
| 22 | P00523_ABJ | ABJ | DB07335 | 24905143 | CHEMBL1230790 | 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL | n/a | |
| 23 | P00523_ACE | ACE | n/a | 177 | CHEMBL170365 | ACETYL GROUP | n/a | |
| 24 | P00523_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 25 | P00523_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 26 | P00523_AMP | AMP | DB00131 | 6083 | CHEMBL752 | ADENOSINE MONOPHOSPHATE | n/a | |
| 27 | P00523_AQB | AQB | n/a | 60202314 | CHEMBL2403819 | N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-4-(dimethylamino)butanamide | n/a | |
| 28 | P00523_AQM | AQM | n/a | 60202315 | CHEMBL2403820 | N-(4-{[4-({[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]carbamoyl}amino)phenyl]amino}quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide | n/a | |
| 29 | P00523_AQU | AQU | n/a | 60202316 | CHEMBL2403816 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-[4-(quinazolin-4-ylamino)phenyl]urea | n/a | |
| 30 | P00523_B5A | B5A | n/a | 56835766 | CHEMBL2030559 | 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 31 | P00523_BK5 | BK5 | n/a | 49850435 | CHEMBL1785021 | 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 32 | P00523_CAC | CAC | n/a | 167250 | n/a | CACODYLATE ION | n/a | |
| 33 | P00523_CU | CU | n/a | 27099 | n/a | COPPER (II) ION | n/a | |
| 34 | P00523_DJK | DJK | DB07662 | 4708 | CHEMBL285063 | N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE | n/a | IC50(nM) = 340.0 |
| 35 | P00523_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 36 | P00523_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 37 | P00523_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 38 | P00523_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 39 | P00523_G6G | G6G | n/a | 25195368 | CHEMBL1214254 | N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide | n/a | |
| 40 | P00523_G6H | G6H | n/a | 25195369 | n/a | N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide | n/a | |
| 41 | P00523_G97 | G97 | n/a | 49867019 | CHEMBL1232944 | N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide | n/a | |
| 42 | P00523_GLY | GLY | DB00145 | 750;5257127; | CHEMBL773 | GLYCINE | n/a | |
| 43 | P00523_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 44 | P00523_GUT | GUT | n/a | 145945998 | CHEMBL4795863 | ~{N}-[3-[3-ethyl-6-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxidanylidene-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide | n/a | |
| 45 | P00523_GUW | GUW | n/a | 145945999 | n/a | ~{N}-[3-(4-methoxy-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]prop-2-enamide | n/a | |
| 46 | P00523_I14 | I14 | n/a | 146170583 | n/a | N-(3-{[4-amino-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]ethynyl}-4-methylphenyl)acetamide | n/a | |
| 47 | P00523_I76 | I76 | n/a | 53345021 | CHEMBL2078817 | 3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 48 | P00523_IHH | IHH | DB07966 | 16040294 | n/a | [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | n/a | |
| 49 | P00523_KS1 | KS1 | DB08052 | 24905142 | CHEMBL1081312 | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 50 | P00523_KS4 | KS4 | DB08053 | 24905153 | CHEMBL1233881 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 51 | P00523_KS5 | KS5 | DB08054 | 24905152 | CHEMBL1233882 | 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 52 | P00523_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 53 | P00523_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 54 | P00523_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 55 | P00523_NG7 | NG7 | n/a | 51359962 | CHEMBL2148124 | 3-{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromet hyl)phenyl}benzamide | n/a | |
| 56 | P00523_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
| 57 | P00523_O44 | O44 | n/a | 126956694 | CHEMBL4855850 | 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride | n/a | |
| 58 | P00523_PD3 | PD3 | n/a | 25011744 | n/a | 1-{3-[(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | n/a | |
| 59 | P00523_PD5 | PD5 | n/a | 25011745 | n/a | 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | n/a | |
| 60 | P00523_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 61 | P00523_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 62 | P00523_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 63 | P00523_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 64 | P00523_PP2 | PP2 | DB03023 | n/a | n/a | 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | n/a | |
| 65 | P00523_RBS | RBS | DB08462 | 10401956 | CHEMBL1221699 | N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE | n/a | |
| 66 | P00523_RCK | RCK | n/a | 156613447 | n/a | ~{N}-[(2-fluorophenyl)methyl]-6-(morpholin-4-ylmethylsulfanyl)-1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 67 | P00523_RXT | RXT | DB08877 | 25126798 | CHEMBL1789941 | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | n/a | |
| 68 | P00523_S56 | S56 | n/a | 137349983 | n/a | (2S)-3-[4-amino-7-(2-methoxyethyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanamide | n/a | |
| 69 | P00523_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 70 | P00523_TZ0 | TZ0 | DB15149 | 71621331 | CHEMBL3701238 | 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | n/a | |
| 71 | P00523_URE | URE | DB03904 | 1176 | CHEMBL985 | UREA | n/a | |
| 72 | P00523_VGG | VGG | DB08699 | 24865390 | CHEMBL1236661 | 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 73 | P00523_VSP | VSP | n/a | 70115992 | CHEMBL3907668 | N-(3-{[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl}phenyl)ethanesulfonamide | n/a | |
| 74 | P00523_SR2 | SR2 | DB08564 | 5328969 | CHEMBL94061 | (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide | n/a | IC50(nM) = 236.0 |
| 75 | P00523_STI | STI | DB00619 | 5291 | CHEMBL941 | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | n/a | IC50(nM) = 2784.0 |
| 76 | P00523_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a |