Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P00800 THER_BACTH
Gene name: npr
Protein name: Thermolysin (EC 3.4.24.27)

List of molecules and drugs that interact with protein P00800

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P00800_0A9 0A9 DB06838 736234 CHEMBL51969 methyl L-phenylalaninate n/a
2 P00800_0DB 0DB n/a 9869588 n/a N-({1-[(2S)-2-carboxy-4-phenylbutyl]cyclopentyl}carbonyl)-L-tryptophan n/a
3 P00800_0FA 0FA n/a 134205 CHEMBL47541 N~2~-phosphono-L-leucinamide n/a
4 P00800_0PI 0PI n/a 449586 n/a N-[(2R,4S)-4-hydroxy-2-(2-methylpropyl)-4-oxido-7-oxo-9-phenyl-3,8-dioxa-6-aza-4-phosphanonan-1-oyl]-L-leucine n/a
5 P00800_0PJ 0PJ n/a 449567 CHEMBL1229588 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-leucine n/a
6 P00800_0PK 0PK n/a 5492587 n/a N-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-L-leucyl-L-alanine n/a
7 P00800_0PQ 0PQ n/a 5289194;58263407; n/a N-{(2R)-3-[(S)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine n/a
8 P00800_0ZN 0ZN n/a 23586078 n/a N-[(1R)-1-carboxy-3-phenylpropyl]-L-leucyl-L-tryptophan n/a
9 P00800_1U4 1U4 n/a 44608005 n/a N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-phenylalanyl-L-leucine n/a
10 P00800_2G6 2G6 n/a 73659163 CHEMBL3558969 P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-1-((3,3-dimethylbutyl)amino)-4-methyl-1-oxopentan-2-yl)phosphonamidic acid n/a
11 P00800_2G7 2G7 n/a 73386664 CHEMBL3559182 P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-1-(isobutylamino)-4-methyl-1-oxopentan-2-yl)phosphonamidic acid n/a
12 P00800_2G8 2G8 n/a 73386666 CHEMBL3559023 P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-4-methyl-1-oxo-1-(propylamino)pentan-2-yl)phosphonamidic acid n/a
13 P00800_2G9 2G9 n/a 73386667 n/a P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-4-methyl-1-(((S)-2-methylbutyl)amino)-1-oxopentan- 2-yl)phosphonamidic acid n/a
14 P00800_2GC 2GC n/a 73386665 CHEMBL3558970 P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-4-methyl-1-oxo-1-(phenethylamino)pentan-2-yl)phosphonamidic acid n/a
15 P00800_2GZ 2GZ n/a 73386669 CHEMBL3559030 P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-4-methyl-1-(neopentylamino)-1-oxopentan-2-yl)phosphonamidic acid n/a
16 P00800_2H0 2H0 n/a 73386668 CHEMBL3559181 P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)phosphonamidic acid n/a
17 P00800_3PL 3PL n/a 7707 CHEMBL440161 3-PHENYLPROPANAL n/a
18 P00800_45X 45X n/a 854051 CHEMBL1256004 2-(pyridin-3-yl)ethanamine n/a
19 P00800_47J 47J n/a 1257670 CHEMBL4568622 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine n/a
20 P00800_4BR 4BR DB07103 5287517 n/a 2-(4-METHYLPHENOXY)ETHYLPHOSPHINATE n/a
21 P00800_5H8 5H8 n/a 91971399 CHEMBL3558978 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-3-methyl-L-valine n/a
22 P00800_5H9 5H9 n/a 91971400 CHEMBL3558981 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-4-methyl-L-leucine n/a
23 P00800_6MG 6MG n/a 122707099 n/a N~2~-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-[(2S)-2,3,3-trimethylbutyl]-L-leucinamide n/a
24 P00800_6NG 6NG n/a 122707100 n/a N~2~-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-[(2R)-2,3,3-trimethylbutyl]-L-leucinamide n/a
25 P00800_6NN 6NN n/a 122707102 n/a P-((((benzyloxy)carbonyl)amino)methyl)-N-((S)-4-methyl-1-(((R)-2-methylbutyl)amino)-1-oxopentan- 2-yl)phosphonamidic acid n/a
26 P00800_6QC 6QC n/a 137348510 n/a ~{N}-[(2~{S})-1-[[(2~{R})-2,3-dimethylbutyl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid n/a
27 P00800_6XO 6XO n/a 122707111 n/a (2~{S})-3-cyclohexyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]pentanoyl]amino]propanoic acid n/a
28 P00800_79E 79E n/a 122707113 n/a JC96 n/a
29 P00800_79F 79F n/a 129318944 n/a (2~{S})-4-methyl-2-[[(2~{S})-3-oxidanyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]propanoyl]amino]pentanoic acid n/a
30 P00800_7AF 7AF n/a 122707101 n/a ~{N}-[(2~{S})-1-[[(2~{S})-2,3-dimethylbutyl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid n/a
31 P00800_7GR 7GR n/a 129318950 n/a (2~{S})-4-methyl-2-[2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]ethanoylamino]pentanoic acid n/a
32 P00800_7K0 7K0 n/a 129318951 n/a (2~{S})-2-[[(2~{S})-3-azanyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]propanoyl]amino]-4-methyl-pentanoic acid n/a
33 P00800_88B 88B n/a 222878 CHEMBL2164246 4-diazanyl-4-oxidanylidene-butanoic acid n/a
34 P00800_8JH 8JH n/a 129009683 CHEMBL4089641 ~{N}-[(2~{S})-1-(4-azanylbutylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid n/a
35 P00800_8JQ 8JQ n/a 129009684 CHEMBL4089068 ~{N}-[(2~{S})-1-(2-azanylethylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid n/a
36 P00800_8KK 8KK n/a 129009681 CHEMBL4099785 ~{N}-[(2~{S})-1-(3-azanylpropylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid n/a
37 P00800_8KN 8KN n/a n/a CHEMBL4084283 (2~{S})-5-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]pentanoyl]amino]pentanoic acid n/a
38 P00800_8L2 8L2 n/a 129009686 CHEMBL4074127 (2~{S})-3-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]pentanoyl]amino]propanoic acid n/a
39 P00800_8L5 8L5 n/a 129009685 CHEMBL4092038 N-(aminomethyl)-N~2~-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucinamide n/a
40 P00800_8LB 8LB n/a 137348719 CHEMBL4071227 (2~{S})-6-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]pentanoyl]amino]hexanoic acid n/a
41 P00800_ACN ACN n/a 180 CHEMBL14253 ACETONE n/a
42 P00800_ACT ACT DB14511 175 n/a ACETATE ION n/a
43 P00800_ACY ACY DB03166 176;21980959;160748163; CHEMBL539 ACETIC ACID n/a
44 P00800_ALA ALA DB00160 5950;7311724; CHEMBL279597 ALANINE n/a
45 P00800_AMM AMM n/a 5494407 n/a (2S)-2-{[(AMINOMETHYL)(DIHYDROXY)SILYL]METHYL}-4-METHYLPENTANAL n/a
46 P00800_ANL ANL DB06728 6115 CHEMBL538 ANILINE n/a
47 P00800_AR AR n/a 23968 n/a ARGON n/a
48 P00800_ASP ASP DB00128 5960;44367445;139060126; CHEMBL274323 ASPARTIC ACID n/a
49 P00800_B3R B3R n/a 11563 CHEMBL185651 3-bromophenol n/a
50 P00800_BAN BAN DB07434 46937074 n/a HONH-BENZYLMALONYL-L-ALANYLGLYCINE-P-NITROANILIDE n/a
51 P00800_BCT BCT n/a 769;22647601; n/a BICARBONATE ION n/a
52 P00800_BET BET DB04455 248;153685060; CHEMBL95889 TRIMETHYL GLYCINE n/a
53 P00800_BR3 BR3 DB07487 5287837 n/a (6-METHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL)METHYLPHOSPHINATE n/a
54 P00800_BR5 BR5 n/a 5287839 n/a 2-ETHOXYETHYLPHOSPHINATE n/a
55 P00800_BXA BXA DB02198 6227 CHEMBL60851 bromoacetic acid n/a
56 P00800_BYA BYA n/a 71651 CHEMBL1231530 N-(phenylcarbonyl)-beta-alanine n/a
57 P00800_BZS BZS DB07506 444797 CHEMBL259621 L-BENZYLSUCCINIC ACID n/a
58 P00800_CA CA n/a 271 n/a CALCIUM ION n/a
59 P00800_CCN CCN n/a 6342 CHEMBL45211 ACETONITRILE n/a
60 P00800_CD CD n/a 31193 n/a CADMIUM ION n/a
61 P00800_CL CL n/a 312 n/a CHLORIDE ION n/a
62 P00800_CO CO n/a 104729 n/a COBALT (II) ION n/a
63 P00800_CU CU n/a 27099 n/a COPPER (II) ION n/a
64 P00800_CU1 CU1 n/a 104815 n/a COPPER (I) ION n/a
65 P00800_D38 D38 n/a 44608007 n/a N~2~-[(2S)-2-{[1-(4-carboxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-3-methylbutanoyl]-L-lysine n/a
66 P00800_DAL DAL DB01786 71080;7311725; CHEMBL66693 D-ALANINE n/a
67 P00800_DAR DAR DB04027 1549104;17753939;58433835;59667378; n/a D-ARGININE n/a
68 P00800_DAS DAS DB02655 83887;139148725; CHEMBL29757 D-ASPARTIC ACID n/a
69 P00800_DGL DGL DB02517 23327;139054390; CHEMBL76232 D-GLUTAMIC ACID n/a
70 P00800_DMF DMF DB01844 6228 CHEMBL268291 DIMETHYLFORMAMIDE n/a
71 P00800_DMS DMS DB01093 679 CHEMBL504 DIMETHYL SULFOXIDE n/a
72 P00800_DTH DTH n/a 69435;6995277; CHEMBL1232386 D-THREONINE n/a
73 P00800_EDO EDO n/a 174 CHEMBL457299 1,2-ETHANEDIOL n/a
74 P00800_FE FE n/a 29936 n/a FE (III) ION n/a
75 P00800_GLO GLO DB01914 107526 CHEMBL448805 D-glucose n/a
76 P00800_GLU GLU DB00142 33032;44272391;88747398; CHEMBL575060 GLUTAMIC ACID n/a
77 P00800_GOL GOL DB09462 753 CHEMBL692 GLYCEROL n/a
78 P00800_ILE ILE DB00167 6306;7043901; CHEMBL1233584 ISOLEUCINE n/a
79 P00800_INC INC DB07989 5288636 n/a 2-(ACETYL-HYDROXY-AMINO)-4-METHYL-PENTANOIC ACID METHYL ESTER n/a
80 P00800_IPA IPA DB02325 3776 CHEMBL582 ISOPROPYL ALCOHOL n/a
81 P00800_IPH IPH DB03255 996;20488062; CHEMBL14060 PHENOL n/a
82 P00800_JC2 JC2 n/a 129009680 CHEMBL4062580 (2~{S})-4-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]pentanoyl]amino]butanoic acid n/a
83 P00800_KR KR n/a 5416 CHEMBL1233877 KRYPTON n/a
84 P00800_L4Z L4Z n/a 89158274 n/a (2,5-dimethylpyrazol-3-yl)methylcarbamic acid n/a
85 P00800_L5Q L5Q n/a 9463852 n/a 5-methyl-~{N}-[2,2,2-tris(fluoranyl)ethyl]-1,2-oxazole-3-carboxamide n/a
86 P00800_L5W L5W n/a n/a n/a ~{N}-oxidanylbicyclo[2.2.1]heptane-1-carboxamide n/a
87 P00800_LEN LEN n/a 7894 CHEMBL42003 3-METHYLBUTAN-1-AMINE n/a
88 P00800_LEU LEU DB00149 6106;7045798; CHEMBL291962 LEUCINE n/a
89 P00800_LNO LNO DB03308 3080766 CHEMBL303296 L-LEUCYL-HYDROXYLAMINE n/a Kd(nM) = 190546.0
90 P00800_LYS LYS DB00123 641599;5460926;24848423;162317967; n/a LYSINE n/a
91 P00800_M3S M3S n/a 78094 CHEMBL1234172 2-(acetyloxy)-3-methylbenzoic acid n/a
92 P00800_MN MN n/a 27854 n/a MANGANESE (II) ION n/a
93 P00800_MOH MOH n/a 887 CHEMBL14688 METHANOL n/a
94 P00800_MPD MPD DB03564 5288834 n/a (4S)-2-METHYL-2,4-PENTANEDIOL n/a
95 P00800_MRD MRD n/a 5288845 n/a (4R)-2-METHYLPENTANE-2,4-DIOL n/a
96 P00800_NA NA n/a 923 n/a SODIUM ION n/a
97 P00800_NMU NMU n/a 11719 n/a N-METHYLUREA n/a
98 P00800_NX6 NX6 n/a 2723942 CHEMBL1222275 N-[(benzyloxy)carbonyl]-L-aspartic acid n/a
99 P00800_OXY OXY DB09140 977 CHEMBL1234886 OXYGEN MOLECULE n/a
100 P00800_P33 P33 DB03394 79718 n/a 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL n/a
101 P00800_P6G P6G n/a 17472 CHEMBL1235082 HEXAETHYLENE GLYCOL n/a
102 P00800_PE5 PE5 DB03556 657096 n/a 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL n/a
103 P00800_PEG PEG n/a 8117 CHEMBL1235226 DI(HYDROXYETHYL)ETHER n/a
104 P00800_PG4 PG4 n/a 8200 CHEMBL1235254 TETRAETHYLENE GLYCOL n/a
105 P00800_PGE PGE DB02327 8172 CHEMBL1235259 TRIETHYLENE GLYCOL n/a
106 P00800_PGO PGO DB04349 439846 n/a S-1,2-PROPANEDIOL n/a
107 P00800_PHN PHN DB02365 1318 CHEMBL415879 1,10-PHENANTHROLINE n/a IC50(nM) = 360000.0
108 P00800_PHQ PHQ DB04569 10387 CHEMBL1581748 benzyl chlorocarbonate n/a
109 P00800_PO4 PO4 DB14523 1061 n/a PHOSPHATE ION n/a
110 P00800_POL POL DB03175 1031 CHEMBL14687 N-PROPANOL n/a
111 P00800_RDF RDF DB02557 445114 CHEMBL479579 N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN n/a
112 P00800_RRT RRT DB01935 657144 CHEMBL45412 (R)-RETRO-THIORPHAN n/a Ki(nM) = 2300.0
113 P00800_RU RU n/a 168052 n/a RUTHENIUM ION n/a
114 P00800_S3B S3B n/a 44462680 n/a 3-methyl-2-(propanoyloxy)benzoic acid n/a
115 P00800_S7B S7B n/a 44462679 n/a 2-[(cyclopropylcarbonyl)oxy]-3-methylbenzoic acid n/a
116 P00800_SAR SAR DB12519 1088;7311726; CHEMBL304383 SARCOSINE n/a
117 P00800_SCN SCN n/a 9322 n/a THIOCYANATE ION n/a
118 P00800_SO4 SO4 DB14546 1117 n/a SULFATE ION n/a
119 P00800_THR THR DB00156 6288;6971019; CHEMBL291747 THREONINE n/a
120 P00800_TI1 TI1 DB02597 5289469 n/a [2(R,S)-2-SULFANYLHEPTANOYL]-PHE-ALA n/a
121 P00800_TI2 TI2 DB03949 5289470 CHEMBL277238 (2-SULFANYL-3-PHENYLPROPANOYL)-PHE-TYR n/a
122 P00800_TI3 TI3 DB02669 448087 CHEMBL419499 [(2S)-2-SULFANYL-3-PHENYLPROPANOYL]-GLY-(5-PHENYLPROLINE) n/a
123 P00800_TIO TIO DB08626 4369380 CHEMBL298827 (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE n/a Ki(nM) = 1800.0
IC50(nM) = 1800.0
124 P00800_TMO TMO n/a 1145 n/a trimethylamine oxide n/a
125 P00800_TRP TRP DB00150 6305;6923516; CHEMBL54976 TRYPTOPHAN n/a
126 P00800_TRS TRS DB03754 3777159;88088752;152743085; n/a 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL n/a
127 P00800_TYR TYR DB00135 6057;6942100; CHEMBL925 TYROSINE n/a
128 P00800_UB2 UB2 n/a 44608006 CHEMBL1236532 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-alanyl-L-leucine n/a
129 P00800_UB3 UB3 n/a 44543634 n/a N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-valyl-L-leucine n/a
130 P00800_UBS UBS n/a 57411967 CHEMBL3559183 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-valine n/a
131 P00800_UBT UBT n/a 57411966 CHEMBL2219858 N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucylglycine n/a
132 P00800_UBU UBU n/a 57411965 CHEMBL2219861 N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-ethyl-L-leucinamide n/a
133 P00800_UBV UBV n/a 57411964 n/a N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-isoleucine n/a
134 P00800_UBW UBW n/a 57411963 CHEMBL3558976 N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-norvaline n/a
135 P00800_UBX UBX n/a 57411957 CHEMBL2219860 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-methyl-L-leucinamide n/a
136 P00800_UBY UBY n/a 5492580 CHEMBL2219859 N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-alanine n/a
137 P00800_UBZ UBZ n/a 57411962 CHEMBL3558975 (2S)-2-({N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl}amino)butanoic acid n/a
138 P00800_URE URE DB03904 1176 CHEMBL985 UREA n/a
139 P00800_VAL VAL DB00161 6287;6971018;88733505; CHEMBL43068 VALINE n/a
140 P00800_X32 X32 n/a 70680441 CHEMBL3559407 N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-phenylalanine n/a
141 P00800_XE XE n/a 23991 CHEMBL1236802 XENON n/a
142 P00800_XYP XYP n/a 125409 n/a beta-D-xylopyranose n/a
143 P00800_XYS XYS DB03389 6027 n/a alpha-D-xylopyranose n/a
144 P00800_ZN ZN n/a 32051 CHEMBL1236970 ZINC ION n/a
145 P00800_ZNP ZNP n/a 44543638 CHEMBL1236974 (2R)-2-benzyl-3-nitropropanamide n/a