Gene name: TNF
Protein name: Tumor necrosis factor
List of molecules and drugs that interact with protein P01375
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P01375_307 | 307 | n/a | 5327044 | CHEMBL255489 | 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE | n/a | |
| 2 | P01375_38A | 38A | n/a | 15878705 | n/a | (2,4,6-trimethylbenzene-1,3,5-triyl)trimethanol | n/a | |
| 3 | P01375_A6Y | A6Y | n/a | 145714259 | n/a | (S)-{1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol | n/a | |
| 4 | P01375_A7A | A7A | n/a | 145714260 | n/a | (R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol | n/a | |
| 5 | P01375_A7G | A7G | n/a | 118108536 | n/a | 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole | n/a | |
| 6 | P01375_A7M | A7M | n/a | 962431 | CHEMBL1477600 | {1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}methanol | n/a | |
| 7 | P01375_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 8 | P01375_D84 | D84 | n/a | 124139603 | n/a | 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one | n/a | |
| 9 | P01375_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 10 | P01375_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 11 | P01375_JNI | JNI | n/a | 124222736 | CHEMBL4060030 | ~{N}4-(phenylmethyl)-~{N}4-[2-[3-(2-piperazin-1-ylpyrimidin-5-yl)phenyl]phenyl]pyrimidine-2,4-diamine | n/a | |
| 12 | P01375_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 13 | P01375_MRD | MRD | n/a | 5288845 | n/a | (4R)-2-METHYLPENTANE-2,4-DIOL | n/a | |
| 14 | P01375_MTN | MTN | DB08217 | 40428878 | n/a | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate | n/a | |
| 15 | P01375_UTJ | UTJ | n/a | 155294459 | CHEMBL4783333 | [4-(isoquinolin-8-yl)phenyl]acetonitrile | n/a | |
| 16 | P01375_UTM | UTM | n/a | 155294460 | CHEMBL4779359 | 8-[4-(2-{5-[(4-methylpiperazin-1-yl)methyl]-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)phenoxy}ethyl)phenyl]isoquinoline | n/a | |
| 17 | P01375_UTS | UTS | n/a | 563347 | CHEMBL347547 | 1-benzyl-1H-benzimidazole | n/a | |
| 18 | P01375_UTV | UTV | n/a | 155294461 | CHEMBL4779860 | 1-{[2-(difluoromethoxy)phenyl]methyl}-2,2-dimethyl-1,2-dihydro-3H-indol-3-one | n/a | |
| 19 | P01375_UTY | UTY | n/a | 155294462 | CHEMBL4787790 | 3-[(6-{2-[(3R)-4-(hydroxyacetyl)-3-methylpiperazin-1-yl]pyrimidin-5-yl}-2,2-dimethyl-3-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile | n/a | |
| 20 | P01375_VGY | VGY | n/a | 126531356 | CHEMBL4787001 | 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol | n/a | |
| 21 | P01375_DB00608 | n/a | DB00608 | n/a | n/a | Chloroquine | inhibitor | |
| 22 | P01375_ALE | ALE | DB00668 | 5816;139148732; | CHEMBL679 | Epinephrine | antagonist | |
| 23 | P01375_DB00852 | n/a | DB00852 | n/a | n/a | Pseudoephedrine | inhibitor | |
| 24 | P01375_DB01407 | n/a | DB01407 | n/a | n/a | Clenbuterol | other/unknown | |
| 25 | P01375_KNT | KNT | DB01411 | 4887 | CHEMBL21333 | Pranlukast | other/unknown | |
| 26 | P01375_DB01427 | n/a | DB01427 | n/a | n/a | Amrinone | inhibitor | |
| 27 | P01375_TSN | TSN | DB04297 | 444732 | CHEMBL99 | Trichostatin A | downregulator | |
| 28 | P01375_469 | 469 | DB05412 | 9871074 | CHEMBL514201 | Talmapimod | n/a | |
| 29 | P01375_DB05470 | n/a | DB05470 | n/a | n/a | VX-702 | n/a | |
| 30 | P01375_DB05513 | n/a | DB05513 | n/a | n/a | Atiprimod | n/a | |
| 31 | P01375_DB05767 | n/a | DB05767 | n/a | n/a | Andrographolide | n/a | |
| 32 | P01375_9X7 | 9X7 | DB05869 | 12041 | CHEMBL173373 | Ethyl pyruvate | n/a | |
| 33 | P01375_DB05968 | n/a | DB05968 | n/a | n/a | PR-104 | n/a | |
| 34 | P01375_PN6 | PN6 | DB05992 | 9949641 | CHEMBL1096380 | Plinabulin | n/a | |
| 35 | P01375_DB06444 | n/a | DB06444 | n/a | n/a | Dexanabinol | n/a | |
| 36 | P01375_DB08910 | n/a | DB08910 | n/a | n/a | Pomalidomide | inhibitor | IC50(nM) = 33.0 |
| 37 | P01375_DB09221 | n/a | DB09221 | n/a | n/a | Polaprezinc | inhibitor | |
| 38 | P01375_DB11752 | n/a | DB11752 | n/a | n/a | Bryostatin 1 | inducer | |
| 39 | P01375_QO7 | QO7 | DB11967 | 10288191 | CHEMBL3187723 | Binimetinib | n/a | |
| 40 | P01375_DB12140 | n/a | DB12140 | n/a | n/a | Dilmapimod | n/a | |
| 41 | P01375_DB13751 | n/a | DB13751 | n/a | n/a | Glycyrrhizic acid | antagonist |