Gene name: HMGCR
Protein name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
List of molecules and drugs that interact with protein P04035
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P04035_114 | 114 | n/a | 446154 | CHEMBL503456 | (3R,5R)-3,5-dihydroxy-7-[(1S,2S,8S,8aR)-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]h eptanoic acid | n/a | |
| 2 | P04035_115 | 115 | DB01095 | 446155 | CHEMBL1078 | (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | inhibitor | |
| 3 | P04035_116 | 116 | DB00439 | 5287419 | n/a | 7-[4-(4-FLUORO-PHENYL)-5-HYDROXYMETHYL-2,6-DIISOPROPYL-PYRIDIN-3-YL]-3,5-DIHYDROXY-HEPTANOIC ACID | inhibitor | IC50(nM) = 10.0 |
| 4 | P04035_117 | 117 | DB01076 | 60823 | CHEMBL1487 | 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID | inhibitor | |
| 5 | P04035_3HI | 3HI | n/a | 9808225 | CHEMBL1565 | (3R,5R)-7-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid | n/a | |
| 6 | P04035_4HI | 4HI | n/a | 11612975 | CHEMBL488636 | (3R,5R)-7-[4-(benzylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid | n/a | |
| 7 | P04035_5HI | 5HI | n/a | 24812713 | CHEMBL487631 | (3R,5R)-7-[2-(4-fluorophenyl)-4-{[(1S)-2-hydroxy-1-phenylethyl]carbamoyl}-5-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid | n/a | |
| 8 | P04035_6HI | 6HI | n/a | 24812714 | n/a | (3R,5R)-7-{2-[(4-fluorobenzyl)carbamoyl]-4-(4-fluorophenyl)-1-(1-methylethyl)-1H-imidazol-5-yl}-3,5-dihydroxyheptanoic acid | n/a | |
| 9 | P04035_7HI | 7HI | n/a | 49866568 | n/a | (3R,5R)-7-[3-(biphenyl-4-ylcarbamoyl)-2-ethyl-5,6,7,8-tetrahydrocyclohepta[b]pyrrol-1(4H)-yl]-3,5-dihydroxyheptanoic acid | n/a | |
| 10 | P04035_882 | 882 | n/a | 11753476 | CHEMBL389002 | (3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID | n/a | |
| 11 | P04035_8HI | 8HI | n/a | 11763597 | CHEMBL1206225 | (3R,5R)-7-{3-(4-fluorophenyl)-1-(1-methylethyl)-4-phenyl-5-[(4-sulfamoylphenyl)carbamoyl]-1H-pyrrol-2-yl}-3,5-dihydroxyheptanoic acid | n/a | |
| 12 | P04035_9HI | 9HI | n/a | 11592691 | CHEMBL1207424 | (3R,5R)-7-{3-[(4-carbamoylphenyl)sulfamoyl]-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl}-3,5-dihydroxyheptanoic acid | n/a | |
| 13 | P04035_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 14 | P04035_COA | COA | DB01992 | 87642 | CHEMBL1213327 | COENZYME A | inhibitor | |
| 15 | P04035_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 16 | P04035_FBI | FBI | DB01098 | 5288194 | n/a | 7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID | inhibitor | Ki(nM) = 0.9 IC50(nM) = 3.1 |
| 17 | P04035_HMG | HMG | DB03169 | 5288565;131704231; | n/a | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A | n/a | |
| 18 | P04035_HR1 | HR1 | n/a | 11512591 | CHEMBL1207787 | (3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID | n/a | |
| 19 | P04035_HR2 | HR2 | n/a | 16220139 | CHEMBL521039 | (3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID | n/a | |
| 20 | P04035_MAH | MAH | DB04377 | 1662 | CHEMBL50444 | 3-HYDROXY-3-METHYL-GLUTARIC ACID | inhibitor | Ki(nM) = 23.5 IC50(nM) = 4000.0 |
| 21 | P04035_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 22 | P04035_RID | RID | n/a | 11527173 | CHEMBL1207385 | (3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-4-(morpholin-4-ylsulfonyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid | n/a | |
| 23 | P04035_RIE | RIE | n/a | 11656602 | CHEMBL1207355 | (3R,5R)-7-[1-(4-fluorophenyl)-4-(1-methylethyl)-3-{methyl[(1R)-1-phenylethyl]carbamoyl}-1H-pyrazol-5-yl]-3,5-dihydroxyheptanoic acid | n/a | |
| 24 | P04035_SIM | SIM | DB14714 | 64718 | CHEMBL1201391 | Simvastatin acid | n/a | |
| 25 | P04035_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 26 | P04035_NAI | NAI | DB00157 | 439153 | CHEMBL1234616 | NADH | n/a | |
| 27 | P04035_DB00175 | n/a | DB00175 | n/a | n/a | Pravastatin | inhibitor | IC50(nM) = 30.0 |
| 28 | P04035_803 | 803 | DB00227 | 53232 | CHEMBL503 | Lovastatin | inhibitor | IC50(nM) = 2.2 |
| 29 | P04035_DB00439 | n/a | DB00439 | n/a | n/a | Cerivastatin | inhibitor | IC50(nM) = 10.0 |
| 30 | P04035_DB00641 | n/a | DB00641 | n/a | n/a | Simvastatin | inhibitor | Ki(nM) = 2.6 IC50(nM) = 0.9 |
| 31 | P04035_DB01095 | n/a | DB01095 | n/a | n/a | Fluvastatin | inhibitor | |
| 32 | P04035_DB01098 | n/a | DB01098 | n/a | n/a | Rosuvastatin | inhibitor | Ki(nM) = 0.9 IC50(nM) = 3.1 |
| 33 | P04035_2UO | 2UO | DB06693 | 64715 | CHEMBL54440 | Mevastatin | inhibitor | |
| 34 | P04035_PV9 | PV9 | DB08860 | 5282452 | CHEMBL1201753 | Pitavastatin | inhibitor | |
| 35 | P04035_P0T | P0T | DB09061 | 644019 | CHEMBL190461 | Cannabidiol | stimulator | |
| 36 | P04035_DB14011 | n/a | DB14011 | n/a | n/a | Nabiximols | stimulator |