Gene name: NR3C1
Protein name: Glucocorticoid receptor (GR)
List of molecules and drugs that interact with protein P04150
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P04150_29M | 29M | n/a | 86280440 | CHEMBL3605919 | N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide | n/a | |
| 2 | P04150_486 | 486 | DB00834 | 55245 | CHEMBL1276308 | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | antagonist | Ki(nM) = 0.09 IC50(nM) = 0.008 Kd(nM) = 15.0 EC50(nM) = 0.6 |
| 3 | P04150_82H | 82H | n/a | 67041274 | CHEMBL3666807 | Velsecorat | n/a | |
| 4 | P04150_866 | 866 | n/a | 25058139 | n/a | 5-amino-N-[(2S)-2-({[(2,6-dichlorophenyl)carbonyl](ethyl)amino}methyl)-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide | n/a | |
| 5 | P04150_8W5 | 8W5 | n/a | 40000 | CHEMBL2110662 | (1~{S},2~{S},4~{R},6~{R},8~{S},9~{S},11~{S},12~{S},13~{R})-9,13-dimethyl-11-oxidanyl-8-(2-oxidanylethanoyl)-6-propyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one | n/a | |
| 6 | P04150_8W8 | 8W8 | DB12280 | 24825740 | CHEMBL4072756 | 2,2,2-tris(fluoranyl)-~{N}-[(1~{R},2~{S})-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]ethanamide | agonist | |
| 7 | P04150_B9Q | B9Q | n/a | 25013811 | CHEMBL3937635 | ~{N}-[(1~{R},2~{S})-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide | n/a | |
| 8 | P04150_B9T | B9T | n/a | 132275097 | CHEMBL4213734 | ~{N}-[(1~{R},2~{S})-1-(2-bromanyl-4-cyano-phenoxy)-1-(2-cyclopropylpyrimidin-5-yl)propan-2-yl]-2,2-bis(fluoranyl)propanamide | n/a | |
| 9 | P04150_B9W | B9W | n/a | 121248172 | CHEMBL4207852 | 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide | n/a | |
| 10 | P04150_BOG | BOG | n/a | 62852 | CHEMBL446037 | octyl beta-D-glucopyranoside | n/a | |
| 11 | P04150_CPS | CPS | n/a | 107670 | CHEMBL450950 | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | n/a | |
| 12 | P04150_CV7 | CV7 | n/a | 6918281 | CHEMBL4594374 | DESISOBUYTYRYL CICLESONIDE | n/a | |
| 13 | P04150_DAY | DAY | n/a | 3032474 | n/a | 1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]-2-hydroxyethanone | n/a | |
| 14 | P04150_DEX | DEX | DB01234 | 5743 | CHEMBL384467 | DEXAMETHASONE | agonist | Ki(nM) = 0.69 IC50(nM) = 0.5 Kd(nM) = 2.0 EC50(nM) = 0.1 |
| 15 | P04150_E7T | E7T | n/a | 58973277 | CHEMBL3962413 | 5-[[(1S,2R,4R)-4-ethyl-6,7-bis(fluoranyl)-2,5-bis(oxidanyl)-2-(trifluoromethyl)-3,4-dihydro-1H-naphthalen-1-yl]amino]-1H-quinolin-2-one | n/a | |
| 16 | P04150_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 17 | P04150_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 18 | P04150_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 19 | P04150_GW6 | GW6 | DB08906 | 9854489 | CHEMBL1676 | (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate | agonist | Ki(nM) = 0.51 IC50(nM) = 0.0398 EC50(nM) = 0.4 |
| 20 | P04150_HCY | HCY | DB00741 | 5754 | CHEMBL389621 | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione | agonist | Ki(nM) = 30.0 |
| 21 | P04150_HEZ | HEZ | DB02210 | 12374 | CHEMBL458616 | HEXANE-1,6-DIOL | inhibitor | |
| 22 | P04150_HJ4 | HJ4 | n/a | 129304758 | CHEMBL4163069 | (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) | n/a | |
| 23 | P04150_JZN | JZN | n/a | 17747503 | CHEMBL1233786 | 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide | n/a | |
| 24 | P04150_JZR | JZR | n/a | 181215 | n/a | hexyl beta-D-glucopyranoside | n/a | |
| 25 | P04150_JZS | JZS | n/a | 46840169 | n/a | N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1H-indazol-1-yl)benzamide | n/a | |
| 26 | P04150_LSJ | LSJ | n/a | 72710581 | CHEMBL3120317 | N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide | n/a | |
| 27 | P04150_MOF | MOF | DB14512 | 441336 | CHEMBL1161 | MOMETASONE FUROATE | agonist | |
| 28 | P04150_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 29 | P04150_NN7 | NN7 | n/a | 16666386 | CHEMBL3261407 | N-[(2S)-1-[[1-(4-fluorophenyl)indazol-4-yl]amino]propan-2-yl]-2,4,6-trimethyl-benzenesulfonamide | n/a | |
| 30 | P04150_R8C | R8C | n/a | 25013322 | CHEMBL3915997 | 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-yl]acetamide | n/a | |
| 31 | P04150_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 32 | P04150_DB00180 | n/a | DB00180 | n/a | n/a | Flunisolide | agonist | |
| 33 | P04150_DB00223 | n/a | DB00223 | n/a | n/a | Diflorasone | agonist | |
| 34 | P04150_DB00240 | n/a | DB00240 | n/a | n/a | Alclometasone | agonist | |
| 35 | P04150_DB00253 | n/a | DB00253 | n/a | n/a | Medrysone | agonist | |
| 36 | P04150_DB00288 | n/a | DB00288 | n/a | n/a | Amcinonide | agonist | |
| 37 | P04150_DB00324 | n/a | DB00324 | n/a | n/a | Fluorometholone | agonist | |
| 38 | P04150_DB00351 | n/a | DB00351 | n/a | n/a | Megestrol acetate | agonist | |
| 39 | P04150_NOG | NOG | DB00367 | 13109 | CHEMBL1389 | Levonorgestrel | binder | |
| 40 | P04150_DB00394 | n/a | DB00394 | n/a | n/a | Beclomethasone dipropionate | agonist | |
| 41 | P04150_STR | STR | DB00396 | 5994 | CHEMBL103 | Progesterone | partial agonist | Ki(nM) = 30.5 IC50(nM) = 1000.0 |
| 42 | P04150_SNL | SNL | DB00421 | 5833 | CHEMBL1393 | Spironolactone | antagonist | Ki(nM) = 32.6 IC50(nM) = 1400.0 EC50(nM) = 20000.0 |
| 43 | P04150_DB00443 | n/a | DB00443 | n/a | n/a | Betamethasone | agonist | |
| 44 | P04150_DB00547 | n/a | DB00547 | n/a | n/a | Desoximetasone | agonist | |
| 45 | P04150_DB00588 | n/a | DB00588 | n/a | n/a | Fluticasone propionate | agonist | Ki(nM) = 0.238 IC50(nM) = 0.04 EC50(nM) = 0.7 |
| 46 | P04150_DB00591 | n/a | DB00591 | n/a | n/a | Fluocinolone acetonide | agonist | |
| 47 | P04150_DB00596 | n/a | DB00596 | n/a | n/a | Ulobetasol | agonist | |
| 48 | P04150_DB00620 | n/a | DB00620 | n/a | n/a | Triamcinolone | agonist | |
| 49 | P04150_DB00635 | n/a | DB00635 | n/a | n/a | Prednisone | agonist | |
| 50 | P04150_DB00663 | n/a | DB00663 | n/a | n/a | Flumethasone | agonist | |
| 51 | P04150_ZK5 | ZK5 | DB00687 | 31378 | CHEMBL1201388 | Fludrocortisone | agonist | |
| 52 | P04150_NDR | NDR | DB00717 | 6230 | CHEMBL1162 | Norethisterone | agonist | |
| 53 | P04150_DB00764 | n/a | DB00764 | n/a | n/a | Mometasone | agonist | |
| 54 | P04150_DB00769 | n/a | DB00769 | n/a | n/a | Hydrocortamate | agonist | |
| 55 | P04150_DB00838 | n/a | DB00838 | n/a | n/a | Clocortolone | agonist | |
| 56 | P04150_DB00846 | n/a | DB00846 | n/a | n/a | Flurandrenolide | agonist | |
| 57 | P04150_TUA | TUA | DB00860 | 5755 | CHEMBL131 | Prednisolone | agonist | Ki(nM) = 1.1 IC50(nM) = 0.526 EC50(nM) = 2.1 |
| 58 | P04150_DB14596 | n/a | DB14596 | n/a | n/a | Loteprednol etabonate | agonist | |
| 59 | P04150_DB00896 | n/a | DB00896 | n/a | n/a | Rimexolone | agonist | |
| 60 | P04150_DB00959 | n/a | DB00959 | n/a | n/a | Methylprednisolone | agonist | |
| 61 | P04150_XRD | XRD | DB01013 | 32798 | CHEMBL1159650 | Clobetasol propionate | agonist | |
| 62 | P04150_DB01047 | n/a | DB01047 | n/a | n/a | Fluocinonide | agonist | |
| 63 | P04150_DB01130 | n/a | DB01130 | n/a | n/a | Prednicarbate | agonist | |
| 64 | P04150_DB01185 | n/a | DB01185 | n/a | n/a | Fluoxymesterone | antagonist | |
| 65 | P04150_DB01222 | n/a | DB01222 | n/a | n/a | Budesonide | agonist | Ki(nM) = 1.3 IC50(nM) = 0.5 EC50(nM) = 2.0 |
| 66 | P04150_DB01260 | n/a | DB01260 | n/a | n/a | Desonide | agonist | |
| 67 | P04150_DB01380 | n/a | DB01380 | n/a | n/a | Cortisone acetate | agonist | |
| 68 | P04150_DB01384 | n/a | DB01384 | n/a | n/a | Paramethasone | agonist | |
| 69 | P04150_DB01395 | n/a | DB01395 | n/a | n/a | Drospirenone | binder | |
| 70 | P04150_DB01410 | n/a | DB01410 | n/a | n/a | Ciclesonide | agonist | |
| 71 | P04150_AS4 | AS4 | DB04630 | 5839 | CHEMBL273453 | Aldosterone | n/a | |
| 72 | P04150_DB05423 | n/a | DB05423 | n/a | n/a | ORG-34517 | antagonist | |
| 73 | P04150_DB06781 | n/a | DB06781 | n/a | n/a | Difluprednate | agonist | |
| 74 | P04150_DB08867 | n/a | DB08867 | n/a | n/a | Ulipristal | antagonist | |
| 75 | P04150_DB09091 | n/a | DB09091 | n/a | n/a | Tixocortol | binder | |
| 76 | P04150_DB09095 | n/a | DB09095 | n/a | n/a | Difluocortolone | binder | |
| 77 | P04150_DB11619 | n/a | DB11619 | n/a | n/a | Gestrinone | antagonist | |
| 78 | P04150_DB11921 | n/a | DB11921 | n/a | n/a | Deflazacort | agonist | |
| 79 | P04150_DB12637 | n/a | DB12637 | n/a | n/a | Onapristone | n/a | |
| 80 | P04150_DB13003 | n/a | DB13003 | n/a | n/a | Cortivazol | n/a | |
| 81 | P04150_DB13158 | n/a | DB13158 | n/a | n/a | Clobetasone | agonist | |
| 82 | P04150_DB13867 | n/a | DB13867 | n/a | n/a | Fluticasone | agonist | |
| 83 | P04150_DB14538 | n/a | DB14538 | n/a | n/a | Hydrocortisone aceponate | n/a | |
| 84 | P04150_DB14539 | n/a | DB14539 | n/a | n/a | Hydrocortisone acetate | agonist | |
| 85 | P04150_DB14540 | n/a | DB14540 | n/a | n/a | Hydrocortisone butyrate | agonist | |
| 86 | P04150_DB14541 | n/a | DB14541 | n/a | n/a | Hydrocortisone cypionate | n/a | |
| 87 | P04150_DB14542 | n/a | DB14542 | n/a | n/a | Hydrocortisone phosphate | n/a | |
| 88 | P04150_DB14543 | n/a | DB14543 | n/a | n/a | Hydrocortisone probutate | agonist | |
| 89 | P04150_DB14544 | n/a | DB14544 | n/a | n/a | Hydrocortisone valerate | agonist | |
| 90 | P04150_DB14583 | n/a | DB14583 | n/a | n/a | Segesterone acetate | agonist | |
| 91 | P04150_DB14631 | n/a | DB14631 | n/a | n/a | Prednisolone phosphate | agonist | |
| 92 | P04150_DB14649 | n/a | DB14649 | n/a | n/a | Dexamethasone acetate | agonist | |
| 93 | P04150_DB14669 | n/a | DB14669 | n/a | n/a | Betamethasone phosphate | agonist | |
| 94 | P04150_DB15566 | n/a | DB15566 | n/a | n/a | Prednisolone acetate | agonist |