Gene name: NTRK1
Protein name: High affinity nerve
List of molecules and drugs that interact with protein P04629
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P04629_22L | 22L | n/a | 215639 | CHEMBL1369722 | 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one | n/a | |
| 2 | P04629_31V | 31V | n/a | 74627727 | CHEMBL3298266 | N-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}acetamide | n/a | |
| 3 | P04629_31W | 31W | n/a | 74627728 | CHEMBL3298269 | 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea | n/a | |
| 4 | P04629_31X | 31X | n/a | 74627729 | CHEMBL3298162 | 4-(naphthalen-1-yl)-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid | n/a | |
| 5 | P04629_31Y | 31Y | n/a | 73386687 | CHEMBL3298264 | N~4~-[4-(morpholin-4-yl)phenyl]-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine | n/a | |
| 6 | P04629_4EK | 4EK | n/a | 122179546 | CHEMBL3582439 | 6-[(2R)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine | n/a | |
| 7 | P04629_4F6 | 4F6 | n/a | 67029432 | n/a | 4-{6-[(3R)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile | n/a | |
| 8 | P04629_69C | 69C | n/a | 57334388 | CHEMBL3800284 | (6R)-3-(methylsulfanyl)-6-phenyl-1-(1H-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5H)-one | n/a | |
| 9 | P04629_6K0 | 6K0 | n/a | 68904737 | CHEMBL4744936 | N-{4-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-N'-(2,4-difluorophenyl)urea | n/a | |
| 10 | P04629_6K1 | 6K1 | n/a | 124219454 | CHEMBL4790022 | N-{5-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide | n/a | |
| 11 | P04629_6K2 | 6K2 | n/a | 70847539 | CHEMBL3661466 | 2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide | n/a | |
| 12 | P04629_6K4 | 6K4 | DB12269 | 66571548 | CHEMBL4212531 | N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide | n/a | |
| 13 | P04629_6UE | 6UE | n/a | 117967296 | CHEMBL4468886 | 1-(9~{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea | n/a | |
| 14 | P04629_6UF | 6UF | n/a | 46275360 | CHEMBL4085721 | ~{N}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide | n/a | |
| 15 | P04629_6UG | 6UG | n/a | 123131777 | CHEMBL4469569 | 2-fluoranyl-~{N}-[2-(4-fluorophenyl)-6-methyl-pyridin-3-yl]-4-(trifluoromethyl)benzamide | n/a | |
| 16 | P04629_6UH | 6UH | n/a | 117967425 | n/a | 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea | n/a | |
| 17 | P04629_6UJ | 6UJ | n/a | 117968174 | CHEMBL4584074 | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-naphthalen-1-yl-urea | n/a | |
| 18 | P04629_6UK | 6UK | n/a | 123131778 | n/a | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea | n/a | |
| 19 | P04629_6UM | 6UM | n/a | 117967567 | CHEMBL4443139 | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-pyridin-2-yl-urea | n/a | |
| 20 | P04629_7HF | 7HF | n/a | 118128728 | CHEMBL4090531 | 1-[(3S,4R)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea | n/a | |
| 21 | P04629_A0X | A0X | n/a | 168490201 | CHEMBL5422091 | 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | n/a | |
| 22 | P04629_A4U | A4U | n/a | 168490199 | CHEMBL5423601 | N-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | n/a | |
| 23 | P04629_A6X | A6X | n/a | 168490203 | CHEMBL5439833 | 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | n/a | |
| 24 | P04629_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 25 | P04629_AQ6 | AQ6 | DB18052 | 91826737 | CHEMBL4556229 | 4-[[4-azanyl-3-(4-cyclohexylpiperazin-1-yl)-9,10-bis(oxidanylidene)anthracen-1-yl]amino]benzoic acid | n/a | |
| 26 | P04629_B9C | B9C | n/a | 138455164 | CHEMBL4457858 | N-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide | n/a | |
| 27 | P04629_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 28 | P04629_CVY | CVY | n/a | 167530307 | n/a | 4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]-~{N}-[3-(1-methylpyrazol-4-yl)-1~{H}-indazol-5-yl]-2-(trifluoromethyl)benzamide | n/a | |
| 29 | P04629_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 30 | P04629_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 31 | P04629_FKT | FKT | n/a | 163321789 | CHEMBL5195469 | 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide | n/a | |
| 32 | P04629_FKY | FKY | n/a | 118167692 | CHEMBL4210892 | 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide | n/a | |
| 33 | P04629_FQD | FQD | n/a | 727600 | CHEMBL1532322 | 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one | n/a | |
| 34 | P04629_FQG | FQG | n/a | 118497137 | CHEMBL3891994 | 5-{[2,4-dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-N-(2-hydroxy-2-methylpropyl)-1-phenyl-1H-pyrazole-3-carboxamide | n/a | |
| 35 | P04629_FQJ | FQJ | n/a | 5121984 | CHEMBL1896117 | 2,4-dichloro-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzamide | n/a | |
| 36 | P04629_FQM | FQM | n/a | 118456253 | CHEMBL4460719 | 5-{[5-(6-aminopyridin-2-yl)-2-chlorobenzene-1-carbonyl]amino}-1-phenyl-1H-pyrazole-3-carboxamide | n/a | |
| 37 | P04629_GO7 | GO7 | n/a | 118665627 | CHEMBL4203759 | 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide | n/a | |
| 38 | P04629_GOD | GOD | n/a | 118868365 | CHEMBL4207042 | 6-amino-5-{[(3S)-4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide | n/a | |
| 39 | P04629_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 40 | P04629_KWY | KWY | n/a | 16030731 | CHEMBL1475114 | 4-tert-butyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide | n/a | |
| 41 | P04629_L0M | L0M | n/a | 138753310 | n/a | N-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-2-(10H-phenoxazin-10-yl)acetamide | n/a | |
| 42 | P04629_L0P | L0P | n/a | 33006353 | n/a | N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide | n/a | |
| 43 | P04629_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 44 | P04629_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 45 | P04629_OO7 | OO7 | n/a | 146672948 | CHEMBL4861572 | N-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-N'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea | n/a | |
| 46 | P04629_OOD | OOD | n/a | 16276659 | CHEMBL4447685 | 2-[(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)amino]-2-oxoethyl 4-(1H-tetrazol-1-yl)benzoate | n/a | |
| 47 | P04629_OOJ | OOJ | n/a | 50802201 | CHEMBL4458913 | N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea | n/a | |
| 48 | P04629_OOM | OOM | n/a | 4815408 | n/a | N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-2-{[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl}acetamide | n/a | |
| 49 | P04629_OOY | OOY | n/a | 16340618 | CHEMBL4793897 | N-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | n/a | |
| 50 | P04629_OQJ | OQJ | n/a | 46325846 | CHEMBL4755144 | N-(6-{[(5-chloro-2-methoxyphenyl)carbamoyl]amino}-1,3-benzothiazol-2-yl)benzamide | n/a | |
| 51 | P04629_OQM | OQM | n/a | 50750207 | CHEMBL4788009 | 2-[5,7-dimethyl-2-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-N-[3-(trifluoromethyl)phenyl]acetamide | n/a | |
| 52 | P04629_OQS | OQS | n/a | 1433661 | CHEMBL4739922 | N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[1-(4-methoxyphenyl)-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl]acetamide | n/a | |
| 53 | P04629_RCH | RCH | n/a | 131839646 | CHEMBL4457566 | N-tert-butyl-2-[2-[6,6-dimethyl-8-(methylsulfonylamino)-11-oxidanylidene-naphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methyl-pyridine-4-carboxamide | n/a | |
| 54 | P04629_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 55 | P04629_V4Z | V4Z | n/a | 16097523 | CHEMBL457614 | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine | n/a | |
| 56 | P04629_YMX | YMX | DB11986 | 25141092 | CHEMBL1983268 | Entrectinib | inhibitor | |
| 57 | P04629_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 58 | P04629_SRT | SRT | DB14756 | 447315 | CHEMBL225983 | S,R MESO-TARTARIC ACID | n/a | |
| 59 | P04629_TP0 | TP0 | DB00321 | 2160 | CHEMBL629 | Amitriptyline | agonist | IC50(nM) = 60000.0 Kd(nM) = 1800000.0 EC50(nM) = 86000.0 |
| 60 | P04629_STI | STI | DB00619 | 5291 | CHEMBL941 | Imatinib | antagonist | Kd(nM) = 10000.0 |
| 61 | P04629_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | |
| 62 | P04629_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 63 | P04629_DB14723 | n/a | DB14723 | n/a | n/a | Larotrectinib | inhibitor | |
| 64 | P04629_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor |