Gene name: TYMS
Protein name: Thymidylate synthase (TS)
List of molecules and drugs that interact with protein P04818
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P04818_0MZ | 0MZ | n/a | 135820626;137347875; | n/a | 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide | n/a | |
| 2 | P04818_2XB | 2XB | n/a | 11112422;135427303; | CHEMBL2426247 | N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid | n/a | |
| 3 | P04818_7Z9 | 7Z9 | DB12912 | 108189;135400184; | CHEMBL320775 | 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one | n/a | |
| 4 | P04818_7ZC | 7ZC | n/a | 27965 | CHEMBL3769622 | 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine | n/a | |
| 5 | P04818_9MZ | 9MZ | n/a | 135820626;137347875; | n/a | 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide | n/a | |
| 6 | P04818_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 7 | P04818_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 8 | P04818_D16 | D16 | DB00293 | 104758;5281913;135400182; | CHEMBL225071 | TOMUDEX | inhibitor | IC50(nM) = 9.0 |
| 9 | P04818_D96 | D96 | n/a | 138403236 | n/a | N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid | n/a | |
| 10 | P04818_DCM | DCM | DB03798 | 13945 | CHEMBL374699 | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE | n/a | |
| 11 | P04818_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 12 | P04818_FFO | FFO | DB11596 | 149436;135398559; | CHEMBL1908841 | N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid | n/a | |
| 13 | P04818_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 14 | P04818_GSH | GSH | DB00143 | 124886;25246407;171390563; | CHEMBL1543 | GLUTATHIONE | n/a | |
| 15 | P04818_KI3 | KI3 | n/a | 920342 | CHEMBL5492540 | 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol | n/a | |
| 16 | P04818_LYA | LYA | DB00642 | 446556;5288715;135410875; | CHEMBL225072 | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID | inhibitor | |
| 17 | P04818_MTX | MTX | DB00563 | 126941 | CHEMBL34259 | METHOTREXATE | inhibitor | Ki(nM) = 600.0 IC50(nM) = 10.0 |
| 18 | P04818_OE7 | OE7 | n/a | 139207781 | CHEMBL4591345 | 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-chlorobenzoic acid | n/a | |
| 19 | P04818_OED | OED | n/a | 139207783 | CHEMBL4445927 | [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid | n/a | |
| 20 | P04818_OEJ | OEJ | n/a | 139207787 | CHEMBL4562561 | 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid | n/a | |
| 21 | P04818_OF7 | OF7 | n/a | 139207782 | CHEMBL4447254 | [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)phenyl]acetic acid | n/a | |
| 22 | P04818_PBX | PBX | n/a | 21951637 | n/a | 4-bromobenzene-1,2,3-triol | n/a | |
| 23 | P04818_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 24 | P04818_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 25 | P04818_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 26 | P04818_TIY | TIY | n/a | 5281571;135403797; | CHEMBL66953 | 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | n/a | |
| 27 | P04818_UFP | UFP | DB03761 | 8642 | CHEMBL886 | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | n/a | |
| 28 | P04818_UMP | UMP | DB03800 | 65063 | CHEMBL211312 | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | n/a | Ki(nM) = 3000.0 |
| 29 | P04818_DB00322 | n/a | DB00322 | n/a | n/a | Floxuridine | inhibitor | |
| 30 | P04818_DB00432 | n/a | DB00432 | n/a | n/a | Trifluridine | inhibitor | |
| 31 | P04818_GEO | GEO | DB00441 | 60750 | CHEMBL888 | Gemcitabine | inhibitor | |
| 32 | P04818_URF | URF | DB00544 | 3385;5281053; | CHEMBL185 | Fluorouracil | other/unknown | |
| 33 | P04818_DB01101 | n/a | DB01101 | n/a | n/a | Capecitabine | inhibitor | |
| 34 | P04818_DT | DT | DB01643 | 9700 | CHEMBL394429 | Thymidine monophosphate | product of | |
| 35 | P04818_CB3 | CB3 | DB03541 | 443388;5281971;135438608; | CHEMBL389051 | 10-Propargyl-5,8-Dideazafolic Acid | n/a | |
| 36 | P04818_CME | CME | DB04530 | n/a | n/a | S,S-(2-Hydroxyethyl)Thiocysteine | n/a | |
| 37 | P04818_DB05116 | n/a | DB05116 | n/a | n/a | Thymectacin | n/a | |
| 38 | P04818_DB06813 | n/a | DB06813 | n/a | n/a | Pralatrexate | substrate | |
| 39 | P04818_CP7 | CP7 | DB07577 | 93114 | CHEMBL22148 | 2,4-Diamino-5-phenyl-6-ethylpyrimidine | n/a | |
| 40 | P04818_RJ1 | RJ1 | DB08478 | 425841 | CHEMBL219484 | N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide | n/a | |
| 41 | P04818_RJ6 | RJ6 | DB08479 | 2730282 | CHEMBL1235693 | N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide | n/a | |
| 42 | P04818_WRA | WRA | DB08734 | 121750 | CHEMBL129788 | 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE | n/a | |
| 43 | P04818_DB09256 | n/a | DB09256 | n/a | n/a | Tegafur | inhibitor | |
| 44 | P04818_DB09327 | n/a | DB09327 | n/a | n/a | Tegafur-uracil | antagonist |