Gene name: CYP17A1
Protein name: Steroid 17-alpha-hydroxylase/17,20 lyase
List of molecules and drugs that interact with protein P05093
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P05093_3NQ | 3NQ | n/a | 118858334 | CHEMBL4280255 | 6-oxime-17-(3-pyridyl)-androst-16-en-3-ol | n/a | |
| 2 | P05093_3NR | 3NR | n/a | 118691599 | CHEMBL4209941 | 6-cyano-17-(3-pyridyl)-androst-5,16-dien-3-ol | n/a | |
| 3 | P05093_3NX | 3NX | n/a | 118691578 | CHEMBL4210141 | 3-hydroxy-17-(3-pyridyl)-androst-5,16-dien-6-amide | n/a | |
| 4 | P05093_3QZ | 3QZ | DB14570 | 6238 | CHEMBL1062 | (9beta)-17-hydroxypregn-4-ene-3,20-dione | n/a | |
| 5 | P05093_6D7 | 6D7 | n/a | 10335364 | CHEMBL1921985 | (R)-orteronel | n/a | |
| 6 | P05093_6D8 | 6D8 | DB12275 | 78357816 | CHEMBL3264610 | VT-464 | inhibitor | |
| 7 | P05093_7D6 | 7D6 | DB12066 | 9796590 | CHEMBL1921976 | (S)-orteronel | n/a | |
| 8 | P05093_8QD | 8QD | n/a | 10089316 | n/a | (3alpha,5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-ol | n/a | |
| 9 | P05093_AER | AER | DB05812 | 132971 | CHEMBL254328 | Abiraterone | inhibitor | IC50(nM) = 2.0 |
| 10 | P05093_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 11 | P05093_HEM | HEM | DB18267 | n/a | n/a | PROTOPORPHYRIN IX CONTAINING FE | n/a | |
| 12 | P05093_LZZ | LZZ | n/a | 91451 | CHEMBL408706 | (3alpha,8alpha)-3,17-dihydroxypregn-5-en-20-one | n/a | |
| 13 | P05093_PLO | PLO | DB02789 | 8955 | CHEMBL253363 | (3BETA)-3-HYDROXYPREGN-5-EN-20-ONE | n/a | |
| 14 | P05093_TOK | TOK | DB12415 | 11188409 | CHEMBL2105738 | (3alpha,8alpha)-17-(1H-benzimidazol-1-yl)androsta-5,16-dien-3-ol | n/a | |
| 15 | P05093_U7P | U7P | n/a | 196941 | CHEMBL132778 | (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one | n/a | |
| 16 | P05093_UDJ | UDJ | n/a | 11725391 | n/a | (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one | n/a | |
| 17 | P05093_XPK | XPK | n/a | 168474078 | n/a | [(1~{R})-1-[(3~{S},5~{S},8~{R},9~{S},10~{S},13~{S},17~{R})-3-methanoyloxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,13,14,15,16,17-hexadecahydrocyclopenta[a]phenanthren-17-yl]ethyl]-methylidyne-azanium | n/a | |
| 18 | P05093_STR | STR | DB00396 | 5994 | CHEMBL103 | PROGESTERONE | substrate | |
| 19 | P05093_NAI | NAI | DB00157 | 439153 | CHEMBL1234616 | NADH | n/a | |
| 20 | P05093_SNL | SNL | DB00421 | 5833 | CHEMBL1393 | Spironolactone | n/a | |
| 21 | P05093_DB01026 | n/a | DB01026 | n/a | n/a | Ketoconazole | inhibitor | IC50(nM) = 48.0 |
| 22 | P05093_KLN | KLN | DB05667 | 47576 | CHEMBL295698 | Levoketoconazole | inhibitor | |
| 23 | P05093_P0T | P0T | DB09061 | 644019 | CHEMBL190461 | Cannabidiol | inhibitor | |
| 24 | P05093_DB14011 | n/a | DB14011 | n/a | n/a | Nabiximols | inhibitor |