Gene name: LCK
Protein name: Tyrosine-protein kinase Lck
List of molecules and drugs that interact with protein P06239
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P06239_1N8 | 1N8 | n/a | 15991575 | CHEMBL212953 | N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE | n/a | |
| 2 | P06239_1N9 | 1N9 | n/a | 11843159 | CHEMBL386760 | 2,6-DIMETHYLPHENYL 2-(3,5-DIMETHOXY-4-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)PHENYLAMINO)PYRIMIDIN- 4-YL(2,4-DIMETHOXYPHENYL)CARBAMATE | n/a | |
| 3 | P06239_242 | 242 | DB06925 | 15991573 | CHEMBL385937 | 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE | n/a | IC50(nM) = 0.2 |
| 4 | P06239_547 | 547 | DB07146 | 11553058 | CHEMBL392990 | 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE | n/a | IC50(nM) = 210.0 |
| 5 | P06239_5LK | 5LK | n/a | 49866534 | n/a | 4-{(6R,7R)-7-amino-3-[3-(4-methylpiperazin-1-yl)phenyl]-6,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl}phenol | n/a | |
| 6 | P06239_5PB | 5PB | n/a | 2747097 | n/a | 4-[4-(benzyloxy)phenyl]-5-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-2,4-dihydro-3H-1,2,4-triazol-3-one | n/a | |
| 7 | P06239_7KW | 7KW | n/a | 68566787 | n/a | N-phenyl-4-(5-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine | n/a | |
| 8 | P06239_925 | 925 | n/a | 45486342 | CHEMBL569078 | 3-[7-[(3-hydroxyphenyl)amino]pyrazolo[1,5-a]pyrimidin-2-yl]-N-(1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-yl)benzamide | n/a | |
| 9 | P06239_979 | 979 | DB07297 | 17756743 | CHEMBL247272 | 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE | n/a | IC50(nM) = 81.0 |
| 10 | P06239_9NH | 9NH | n/a | 23627200 | n/a | N-[5-({[2-fluoro-3-(trifluoromethyl)phenyl]amino}carbonyl)-2-methylphenyl]-4-methoxy-2-[(4-piperazin-1-ylphenyl)amino]pyrimidine-5-carboxamide | n/a | |
| 11 | P06239_ACE | ACE | n/a | 177 | CHEMBL170365 | ACETYL GROUP | n/a | |
| 12 | P06239_AM0 | AM0 | n/a | 23536770 | CHEMBL271131 | N-phenyl-1-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}-1H-benzimidazol-2-amine | n/a | |
| 13 | P06239_AM5 | AM5 | n/a | 24823586 | CHEMBL408070 | 4-methyl-N~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-N~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide | n/a | |
| 14 | P06239_AM6 | AM6 | n/a | 24823590 | CHEMBL271140 | 2-methyl-N-{4-methyl-3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)carbamoyl]phenyl}-3-(trifluoromethyl)benzamide | n/a | |
| 15 | P06239_AM9 | AM9 | n/a | 11785878 | CHEMBL410295 | 6-(2,6-dimethylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | n/a | |
| 16 | P06239_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 17 | P06239_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | P06239_CC0 | CC0 | DB04003 | 446300 | n/a | (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID | n/a | |
| 19 | P06239_CC1 | CC1 | DB01830 | 445561 | n/a | {4-[2-ACETYLAMINO-2-(3-CARBAMOYL-2-CYCLOHEXYLMETHOXY-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENYL}-PHOSPHONIC ACID | n/a | |
| 20 | P06239_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 21 | P06239_CXS | CXS | DB02219 | 70815;12546061; | n/a | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID | n/a | |
| 22 | P06239_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 23 | P06239_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 24 | P06239_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | P06239_KBM | KBM | n/a | 2797594 | n/a | (4-chlorophenyl)(5-methoxy-1-benzofuran-2-yl)methanone | n/a | |
| 26 | P06239_KSC | KSC | n/a | 52941589 | n/a | 7-[(cyclopropylmethyl)amino]-2-[(4-methoxyphenyl)amino]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 27 | P06239_KSE | KSE | n/a | 16743447 | CHEMBL260114 | 7-[(2-amino-2-methylpropyl)amino]-2-[(3,5-dimethoxyphenyl)amino]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 28 | P06239_KSF | KSF | DB08055 | 44563262 | CHEMBL462228 | N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | n/a | IC50(nM) = 220.0 |
| 29 | P06239_KSH | KSH | n/a | 49867206 | n/a | 2-[(3,5-dimethoxyphenyl)amino]-5-ethyl-7-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 30 | P06239_KSK | KSK | n/a | 16743628 | n/a | 7-[(2-amino-2-methylpropyl)amino]-5-cyclopropyl-2-[(3,5-dimethoxyphenyl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 31 | P06239_KSL | KSL | DB08056 | 44422489 | CHEMBL223873 | N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | n/a | IC50(nM) = 20.0 |
| 32 | P06239_KSM | KSM | DB08057 | 46937119 | n/a | N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine | n/a | |
| 33 | P06239_KSR | KSR | n/a | 9860448 | CHEMBL1233887 | 6-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine | n/a | |
| 34 | P06239_KSS | KSS | n/a | 11301507 | n/a | 7-(3,4-dimethoxyphenyl)-5-(ethylsulfanyl)imidazo[1,2-c]pyrimidine | n/a | |
| 35 | P06239_KZI | KZI | n/a | 46174151 | n/a | 5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(3,5-dimethoxyphenyl)amino]pyrazine-2-carboxamide | n/a | |
| 36 | P06239_KZL | KZL | n/a | 49867213 | n/a | 5-[(2-amino-1,1-dimethylethyl)amino]-7-[(3,5-dimethoxyphenyl)amino][1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide | n/a | |
| 37 | P06239_KZM | KZM | n/a | 10324311 | n/a | 5-{[(1R,2S)-2-aminocyclohexyl]amino}-7-[(3,5-dimethoxyphenyl)amino]-2-(3-hydroxyphenyl)[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide | n/a | |
| 38 | P06239_LHL | LHL | n/a | 22125070 | CHEMBL1234002 | 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | n/a | |
| 39 | P06239_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 40 | P06239_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 41 | P06239_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
| 42 | P06239_ODJ | ODJ | n/a | 139209093 | CHEMBL4469360 | N-{4-[(6-methoxypyrazolo[1,5-a]pyridine-3-carbonyl)amino]-3-methylphenyl}-1-methyl-1H-indazole-3-carboxamide | n/a | |
| 43 | P06239_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 44 | P06239_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 45 | P06239_PP2 | PP2 | DB03023 | n/a | n/a | 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | n/a | |
| 46 | P06239_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 47 | P06239_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 48 | P06239_STI | STI | DB00619 | 5291 | CHEMBL941 | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | n/a | Ki(nM) = 6893.0 IC50(nM) = 160.0 Kd(nM) = 40.0 |
| 49 | P06239_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 50 | P06239_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | Dasatinib | inhibitor | IC50(nM) = 0.4 Kd(nM) = 0.2 |
| 51 | P06239_A0P | A0P | DB04395 | 44462678 | n/a | Phosphoaminophosphonic Acid-Adenylate Ester | n/a | |
| 52 | P06239_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | Ponatinib | inhibitor | IC50(nM) = 0.28 |
| 53 | P06239_XIN | XIN | DB09079 | 9809715 | CHEMBL502835 | Nintedanib | inhibitor | |
| 54 | P06239_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 55 | P06239_DB15035 | n/a | DB15035 | n/a | n/a | Zanubrutinib | inhibitor | |
| 56 | P06239_DB16656 | n/a | DB16656 | n/a | n/a | Zotiraciclib | inhibitor |