Gene name: PGR
Protein name: Progesterone receptor (PR)
List of molecules and drugs that interact with protein P06401
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P06401_2S0 | 2S0 | n/a | 130904 | CHEMBL260538 | [(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopen ta[a]phenanthren-17-yl] acetate | n/a | |
| 2 | P06401_30X | 30X | n/a | 11326074 | n/a | N~2~-[4-cyano-3-(trifluoromethyl)phenyl]-N,N-dimethyl-N~2~-(2,2,2-trifluoroethyl)-L-alaninamide | n/a | |
| 3 | P06401_486 | 486 | DB00834 | 55245 | CHEMBL1276308 | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | antagonist | Ki(nM) = 0.251189 IC50(nM) = 0.021 EC50(nM) = 0.3 |
| 4 | P06401_A2K | A2K | n/a | 11555183 | CHEMBL409661 | (8S,11R,13S,14S,16S,17S)-17-cyclopropylcarbonyl-16-ethenyl-13-methyl-11-(4-pyridin-3-ylphenyl)-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one | n/a | |
| 5 | P06401_AS0 | AS0 | DB06680 | 9577221 | CHEMBL267431 | 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME | modulator | |
| 6 | P06401_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 7 | P06401_GKK | GKK | n/a | 16661702 | CHEMBL558664 | 2-chloro-4-{[(3S)-1-methylpyrrolidin-3-yl][2-(trifluoromethyl)benzyl]amino}benzonitrile | n/a | |
| 8 | P06401_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 9 | P06401_MOF | MOF | DB14512 | 441336 | CHEMBL1161 | MOMETASONE FUROATE | n/a | |
| 10 | P06401_NDR | NDR | DB00717 | 6230 | CHEMBL1162 | (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one | agonist | Ki(nM) = 1.9 IC50(nM) = 3.2 Kd(nM) = 0.4 EC50(nM) = 2.2 |
| 11 | P06401_NOG | NOG | DB00367 | 13109 | CHEMBL1389 | 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE | modulator | EC50(nM) = 1.0 |
| 12 | P06401_OR8 | OR8 | n/a | 53313347 | n/a | 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE | n/a | |
| 13 | P06401_ORB | ORB | n/a | 53313348 | n/a | N-{(1R)-1-[4-(2-CHLORO-5-FLUOROPYRIDIN-3-YL)PHENYL]ETHYL}-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE | n/a | |
| 14 | P06401_ORC | ORC | n/a | 53313349 | n/a | (R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE | n/a | |
| 15 | P06401_R18 | R18 | DB02998 | 261000 | CHEMBL166444 | (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE | inhibitor | Ki(nM) = 0.49 |
| 16 | P06401_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 17 | P06401_WOW | WOW | n/a | 16661548 | CHEMBL601500 | 2-chloro-4-{(2-methylbenzyl)[(3S)-1-(methylsulfonyl)pyrrolidin-3-yl]amino}benzonitrile | n/a | |
| 18 | P06401_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 19 | P06401_STR | STR | DB00396 | 5994 | CHEMBL103 | PROGESTERONE | agonist | Ki(nM) = 3.4 IC50(nM) = 0.2 EC50(nM) = 0.1 |
| 20 | P06401_T98 | T98 | DB04787 | 4369524 | CHEMBL539163 | 5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE | agonist | IC50(nM) = 0.5 EC50(nM) = 0.15 |
| 21 | P06401_DB00294 | n/a | DB00294 | n/a | n/a | Etonogestrel | agonist | |
| 22 | P06401_DB00304 | n/a | DB00304 | n/a | n/a | Desogestrel | agonist | |
| 23 | P06401_DB00351 | n/a | DB00351 | n/a | n/a | Megestrol acetate | agonist | |
| 24 | P06401_DB00378 | n/a | DB00378 | n/a | n/a | Dydrogesterone | agonist | |
| 25 | P06401_SNL | SNL | DB00421 | 5833 | CHEMBL1393 | Spironolactone | agonist | Ki(nM) = 399.7 IC50(nM) = 650.0 EC50(nM) = 20000.0 |
| 26 | P06401_DB00431 | n/a | DB00431 | n/a | n/a | Lindane | n/a | |
| 27 | P06401_DB00588 | n/a | DB00588 | n/a | n/a | Fluticasone propionate | agonist | IC50(nM) = 21.0 |
| 28 | P06401_DB00603 | n/a | DB00603 | n/a | n/a | Medroxyprogesterone acetate | agonist | Ki(nM) = 0.338844 IC50(nM) = 11.0 EC50(nM) = 0.1 |
| 29 | P06401_DB00648 | n/a | DB00648 | n/a | n/a | Mitotane | n/a | |
| 30 | P06401_DB00764 | n/a | DB00764 | n/a | n/a | Mometasone | agonist | |
| 31 | P06401_DB00823 | n/a | DB00823 | n/a | n/a | Ethynodiol diacetate | agonist | |
| 32 | P06401_DB00957 | n/a | DB00957 | n/a | n/a | Norgestimate | agonist | |
| 33 | P06401_DB01395 | n/a | DB01395 | n/a | n/a | Drospirenone | agonist | IC50(nM) = 43.3 |
| 34 | P06401_QA1 | QA1 | DB01406 | 28417 | CHEMBL1479 | Danazol | agonist | |
| 35 | P06401_DB01428 | n/a | DB01428 | n/a | n/a | Oxybenzone | antagonist | |
| 36 | P06401_DB01431 | n/a | DB01431 | n/a | n/a | Allylestrenol | agonist | |
| 37 | P06401_PHT | PHT | DB02746 | 1017;18183610; | CHEMBL1045 | Phthalic Acid | n/a | |
| 38 | P06401_DB05253 | n/a | DB05253 | n/a | n/a | Telapristone acetate | n/a | |
| 39 | P06401_DB06713 | n/a | DB06713 | n/a | n/a | Norelgestromin | agonist | |
| 40 | P06401_DB06730 | n/a | DB06730 | n/a | n/a | Gestodene | binder | |
| 41 | P06401_DB06789 | n/a | DB06789 | n/a | n/a | Hydroxyprogesterone caproate | agonist | |
| 42 | P06401_DB08867 | n/a | DB08867 | n/a | n/a | Ulipristal | modulator | |
| 43 | P06401_GW6 | GW6 | DB08906 | 9854489 | CHEMBL1676 | Fluticasone furoate | agonist | IC50(nM) = 21.0 |
| 44 | P06401_DB09123 | n/a | DB09123 | n/a | n/a | Dienogest | agonist | |
| 45 | P06401_DB09124 | n/a | DB09124 | n/a | n/a | Medrogestone | ligand | |
| 46 | P06401_DB09389 | n/a | DB09389 | n/a | n/a | Norgestrel | binder | |
| 47 | P06401_DB11064 | n/a | DB11064 | n/a | n/a | Homosalate | antagonist | |
| 48 | P06401_DB11219 | n/a | DB11219 | n/a | n/a | Enzacamene | antagonist | |
| 49 | P06401_DB11619 | n/a | DB11619 | n/a | n/a | Gestrinone | antagonist | |
| 50 | P06401_DB12941 | n/a | DB12941 | n/a | n/a | Darolutamide | antagonist | |
| 51 | P06401_DB13857 | n/a | DB13857 | n/a | n/a | Demegestone | agonist | |
| 52 | P06401_DB13867 | n/a | DB13867 | n/a | n/a | Fluticasone | agonist | |
| 53 | P06401_DB14583 | n/a | DB14583 | n/a | n/a | Segesterone acetate | agonist |