Gene name: IGF1R
Protein name: Insulin-like growth factor
List of molecules and drugs that interact with protein P08069
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08069_01P | 01P | n/a | 10202829 | CHEMBL1738698 | N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | n/a | |
| 2 | P08069_575 | 575 | DB07156 | 24808489 | CHEMBL263143 | (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione | n/a | |
| 3 | P08069_66A | 66A | n/a | n/a | CHEMBL1614712 | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 4 | P08069_741 | 741 | n/a | 25113180 | CHEMBL460164 | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | n/a | |
| 5 | P08069_8LN | 8LN | n/a | 122177112 | CHEMBL3823007 | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine | n/a | |
| 6 | P08069_ACP | ACP | DB03909 | 91532 | CHEMBL133463 | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | n/a | |
| 7 | P08069_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 8 | P08069_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 9 | P08069_BMI | BMI | DB07474 | 135530418 | CHEMBL397666 | 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE | n/a | |
| 10 | P08069_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 11 | P08069_CCX | CCX | n/a | 46897873 | n/a | 3-cyano-N-{1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}-1H-indole-7-carboxamide | n/a | |
| 12 | P08069_CD | CD | n/a | 31193 | n/a | CADMIUM ION | n/a | |
| 13 | P08069_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 14 | P08069_D94 | D94 | n/a | n/a | CHEMBL249295 | 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine | n/a | |
| 15 | P08069_DYK | DYK | n/a | 91668530 | CHEMBL3421972 | N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | n/a | |
| 16 | P08069_EBI | EBI | DB15399 | 24785538 | CHEMBL575448 | 1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-proli namide | inhibitor | |
| 17 | P08069_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 18 | P08069_GD5 | GD5 | n/a | 122177111 | CHEMBL3822543 | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine | n/a | |
| 19 | P08069_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 20 | P08069_IC2 | IC2 | n/a | 168490210 | n/a | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | n/a | |
| 21 | P08069_ICV | ICV | n/a | 168490213 | n/a | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione | n/a | |
| 22 | P08069_IE0 | IE0 | n/a | 168490211 | n/a | (5S)-5-methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | n/a | |
| 23 | P08069_IEA | IEA | n/a | 11758149 | CHEMBL1762154 | 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione | n/a | |
| 24 | P08069_IED | IED | n/a | 168490212 | n/a | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | n/a | |
| 25 | P08069_IER | IER | n/a | n/a | CHEMBL3037913 | 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol | n/a | |
| 26 | P08069_LGV | LGV | n/a | 49865038 | CHEMBL1222855 | N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide | n/a | |
| 27 | P08069_LGW | LGW | n/a | 25101485 | CHEMBL1222710 | N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{(2S)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | n/a | |
| 28 | P08069_LGX | LGX | n/a | 25101638 | CHEMBL1222711 | N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{(2R)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | n/a | |
| 29 | P08069_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 30 | P08069_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 31 | P08069_MLT | MLT | DB03499 | 92824 | CHEMBL225986 | D-MALATE | n/a | |
| 32 | P08069_MQY | MQY | n/a | 10008365 | CHEMBL1738841 | (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione | n/a | |
| 33 | P08069_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 34 | P08069_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
| 35 | P08069_OZN | OZN | n/a | n/a | n/a | 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide | n/a | |
| 36 | P08069_PDR | PDR | n/a | 11638731 | n/a | 3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridine | n/a | |
| 37 | P08069_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 38 | P08069_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 39 | P08069_A0P | A0P | DB04395 | 44462678 | n/a | Phosphoaminophosphonic Acid-Adenylate Ester | n/a | |
| 40 | P08069_DB06075 | n/a | DB06075 | n/a | n/a | Linsitinib | inhibitor | |
| 41 | P08069_DB08804 | n/a | DB08804 | n/a | n/a | Nandrolone decanoate | inducer | |
| 42 | P08069_6GY | 6GY | DB12267 | 68165256 | CHEMBL3545311 | Brigatinib | inhibitor | |
| 43 | P08069_DB16637 | n/a | DB16637 | n/a | n/a | KW-2450 free base | inhibitor |