Gene name: CHRM2
Protein name: Muscarinic acetylcholine receptor
List of molecules and drugs that interact with protein P08172
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08172_2CU | 2CU | n/a | 57664406 | CHEMBL4089376 | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide | n/a | |
| 2 | P08172_3C0 | 3C0 | DB11315 | n/a | CHEMBL376897 | N-methyl scopolamine | antagonist | |
| 3 | P08172_82F | 82F | n/a | 6604853 | CHEMBL1318307 | N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide | n/a | |
| 4 | P08172_ACH | ACH | DB03128 | 187 | CHEMBL667 | ACETYLCHOLINE | n/a | Ki(nM) = 158.0 EC50(nM) = 7.0 |
| 5 | P08172_BGC | BGC | DB02379 | 64689 | CHEMBL1614854 | beta-D-glucopyranose | n/a | |
| 6 | P08172_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 7 | P08172_HG | HG | n/a | 26623 | n/a | MERCURY (II) ION | n/a | |
| 8 | P08172_IXO | IXO | n/a | 10104167 | CHEMBL3121473 | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium | n/a | |
| 9 | P08172_QNB | QNB | n/a | 688566 | CHEMBL558910 | (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate | n/a | |
| 10 | P08172_SCK | SCK | DB00202 | 5314 | CHEMBL703 | Succinylcholine | agonist | |
| 11 | P08172_DB00246 | n/a | DB00246 | n/a | n/a | Ziprasidone | antagonist | Ki(nM) = 2440.0 |
| 12 | P08172_DB00280 | n/a | DB00280 | n/a | n/a | Disopyramide | antagonist | |
| 13 | P08172_DB00332 | n/a | DB00332 | n/a | n/a | Ipratropium | antagonist | |
| 14 | P08172_DB00334 | n/a | DB00334 | n/a | n/a | Olanzapine | antagonist | |
| 15 | P08172_DB00342 | n/a | DB00342 | n/a | n/a | Terfenadine | binder | |
| 16 | P08172_DB00363 | n/a | DB00363 | n/a | n/a | Clozapine | partial agonist | EC50(nM) = 10000.0 |
| 17 | P08172_DB00376 | n/a | DB00376 | n/a | n/a | Trihexyphenidyl | antagonist | Ki(nM) = 7.0 IC50(nM) = 19.0 |
| 18 | P08172_DB00383 | n/a | DB00383 | n/a | n/a | Oxyphencyclimine | antagonist | |
| 19 | P08172_DB00387 | n/a | DB00387 | n/a | n/a | Procyclidine | antagonist | Ki(nM) = 25.0 |
| 20 | P08172_DB00392 | n/a | DB00392 | n/a | n/a | Profenamine | antagonist | |
| 21 | P08172_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | binder | Ki(nM) = 300.0 |
| 22 | P08172_CCE | CCE | DB00411 | 2551 | CHEMBL965 | Carbamoylcholine | agonist | Ki(nM) = 20.0 IC50(nM) = 3.8 EC50(nM) = 74.0 |
| 23 | P08172_HYO | HYO | DB00424 | n/a | CHEMBL1331216 | Hyoscyamine | antagonist | |
| 24 | P08172_C7H | C7H | DB00434 | 2913 | CHEMBL516 | Cyproheptadine | antagonist | Ki(nM) = 7.0 |
| 25 | P08172_IXX | IXX | DB00458 | 3696 | CHEMBL11 | Imipramine | antagonist | Ki(nM) = 0.13 |
| 26 | P08172_DB00462 | n/a | DB00462 | n/a | n/a | Methscopolamine bromide | antagonist | |
| 27 | P08172_DB00483 | n/a | DB00483 | n/a | n/a | Gallamine triethiodide | antagonist | Ki(nM) = 468.0 IC50(nM) = 776.0 |
| 28 | P08172_DB00496 | n/a | DB00496 | n/a | n/a | Darifenacin | antagonist | Ki(nM) = 12.0 |
| 29 | P08172_DB00505 | n/a | DB00505 | n/a | n/a | Tridihexethyl | antagonist | |
| 30 | P08172_DB00508 | n/a | DB00508 | n/a | n/a | Triflupromazine | antagonist | |
| 31 | P08172_DB00517 | n/a | DB00517 | n/a | n/a | Anisotropine methylbromide | antagonist | |
| 32 | P08172_DB00565 | n/a | DB00565 | n/a | n/a | Cisatracurium | antagonist | |
| 33 | P08172_DB00572 | n/a | DB00572 | n/a | n/a | Atropine | antagonist | Ki(nM) = 0.344 IC50(nM) = 8.1 |
| 34 | P08172_DB00622 | n/a | DB00622 | n/a | n/a | Nicardipine | antagonist | |
| 35 | P08172_DB00725 | n/a | DB00725 | n/a | n/a | Homatropine methylbromide | antagonist | |
| 36 | P08172_DB00728 | n/a | DB00728 | n/a | n/a | Rocuronium | antagonist | |
| 37 | P08172_DB00747 | n/a | DB00747 | n/a | n/a | Scopolamine | antagonist | |
| 38 | P08172_DB00767 | n/a | DB00767 | n/a | n/a | Benzquinamide | antagonist | |
| 39 | P08172_DB00804 | n/a | DB00804 | n/a | n/a | Dicyclomine | antagonist | Ki(nM) = 244.0 |
| 40 | P08172_DB00809 | n/a | DB00809 | n/a | n/a | Tropicamide | antagonist | |
| 41 | P08172_DB00835 | n/a | DB00835 | n/a | n/a | Brompheniramine | antagonist | |
| 42 | P08172_COC | COC | DB00907 | 446220 | CHEMBL370805 | Cocaine | antagonist | |
| 43 | P08172_DB00934 | n/a | DB00934 | n/a | n/a | Maprotiline | antagonist | |
| 44 | P08172_DB00940 | n/a | DB00940 | n/a | n/a | Methantheline | n/a | |
| 45 | P08172_DB00986 | n/a | DB00986 | n/a | n/a | Glycopyrronium | antagonist | Ki(nM) = 1.6 IC50(nM) = 0.158 |
| 46 | P08172_DB01019 | n/a | DB01019 | n/a | n/a | Bethanechol | agonist | |
| 47 | P08172_DB01036 | n/a | DB01036 | n/a | n/a | Tolterodine | antagonist | Ki(nM) = 2.7 |
| 48 | P08172_DB01062 | n/a | DB01062 | n/a | n/a | Oxybutynin | antagonist | Ki(nM) = 8.1 |
| 49 | P08172_DB01069 | n/a | DB01069 | n/a | n/a | Promethazine | antagonist | |
| 50 | P08172_2PM | 2PM | DB01075 | 3100 | CHEMBL657 | Diphenhydramine | antagonist | Ki(nM) = 120.0 |
| 51 | P08172_9PL | 9PL | DB01085 | 5910 | CHEMBL550 | Pilocarpine | agonist | Ki(nM) = 12023.0 EC50(nM) = 63000.0 |
| 52 | P08172_DB01135 | n/a | DB01135 | n/a | n/a | Doxacurium | antagonist | |
| 53 | P08172_DB01142 | no_lig_id | DB01142 | n/a | n/a | Doxepin | antagonist | |
| 54 | P08172_DB01148 | n/a | DB01148 | n/a | n/a | Flavoxate | antagonist | |
| 55 | P08172_DSM | DSM | DB01151 | 2995 | CHEMBL72 | Desipramine | antagonist | Ki(nM) = 66.0 |
| 56 | P08172_DB01224 | n/a | DB01224 | n/a | n/a | Quetiapine | ligand | Ki(nM) = 630.0 |
| 57 | P08172_DB01226 | n/a | DB01226 | n/a | n/a | Mivacurium | antagonist | |
| 58 | P08172_DB01231 | n/a | DB01231 | n/a | n/a | Diphenidol | antagonist | |
| 59 | P08172_9SC | 9SC | DB01238 | 60795 | CHEMBL1112 | Aripiprazole | ligand | Ki(nM) = 3510.0 |
| 60 | P08172_DB01239 | n/a | DB01239 | n/a | n/a | Chlorprothixene | antagonist | |
| 61 | P08172_CU9 | CU9 | DB01336 | 21233 | CHEMBL1259 | Metocurine | antagonist | |
| 62 | P08172_DB01337 | n/a | DB01337 | n/a | n/a | Pancuronium | antagonist | |
| 63 | P08172_DB01338 | n/a | DB01338 | n/a | n/a | Pipecuronium | antagonist | |
| 64 | P08172_DB01403 | n/a | DB01403 | n/a | n/a | Methotrimeprazine | antagonist | |
| 65 | P08172_0HK | 0HK | DB01409 | n/a | CHEMBL1900528 | Tiotropium | antagonist | |
| 66 | P08172_DB01591 | n/a | DB01591 | n/a | n/a | Solifenacin | antagonist | Ki(nM) = 120.0 IC50(nM) = 573.7 |
| 67 | P08172_DB04834 | n/a | DB04834 | n/a | n/a | Rapacuronium | antagonist | |
| 68 | P08172_DB06153 | n/a | DB06153 | n/a | n/a | Pizotifen | antagonist | |
| 69 | P08172_DB06702 | n/a | DB06702 | n/a | n/a | Fesoterodine | antagonist | |
| 70 | P08172_DB06709 | n/a | DB06709 | n/a | n/a | Methacholine | agonist | Ki(nM) = 59.0 IC50(nM) = 380.0 |
| 71 | P08172_DB06787 | n/a | DB06787 | n/a | n/a | Hexocyclium | antagonist | |
| 72 | P08172_DB08801 | n/a | DB08801 | n/a | n/a | Dimetindene | antagonist | Ki(nM) = 45.0 |
| 73 | P08172_DB08897 | n/a | DB08897 | n/a | n/a | Aclidinium | antagonist | Ki(nM) = 0.08 IC50(nM) = 0.126 |
| 74 | P08172_DB09076 | n/a | DB09076 | n/a | n/a | Umeclidinium | antagonist | Ki(nM) = 0.15 |
| 75 | P08172_DB09089 | n/a | DB09089 | n/a | n/a | Trimebutine | antagonist | |
| 76 | P08172_DB09167 | n/a | DB09167 | n/a | n/a | Dosulepin | antagonist | |
| 77 | P08172_DB09185 | n/a | DB09185 | n/a | n/a | Viloxazine | antagonist | |
| 78 | P08172_DB09262 | n/a | DB09262 | n/a | n/a | Imidafenacin | antagonist | |
| 79 | P08172_DB09300 | n/a | DB09300 | n/a | n/a | Butylscopolamine | antagonist | |
| 80 | P08172_DB11181 | n/a | DB11181 | n/a | n/a | Homatropine | antagonist | |
| 81 | P08172_DB11235 | n/a | DB11235 | n/a | n/a | Thonzylamine | antagonist | |
| 82 | P08172_DB12278 | n/a | DB12278 | n/a | n/a | Propiverine | antagonist | |
| 83 | P08172_DB13581 | n/a | DB13581 | n/a | n/a | Rociverine | antagonist | |
| 84 | P08172_DB14185 | n/a | DB14185 | n/a | n/a | Aripiprazole lauroxil | n/a |