Gene name: CHRM4
Protein name: Muscarinic acetylcholine receptor
List of molecules and drugs that interact with protein P08173
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08173_0HK | 0HK | DB01409 | n/a | CHEMBL1900528 | (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane | n/a | |
| 2 | P08173_2CU | 2CU | n/a | 57664406 | CHEMBL4089376 | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide | n/a | |
| 3 | P08173_5XI | 5XI | n/a | 9864275 | n/a | methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate | n/a | |
| 4 | P08173_ACH | ACH | DB03128 | 187 | CHEMBL667 | ACETYLCHOLINE | n/a | Ki(nM) = 5400.0 EC50(nM) = 10.0 |
| 5 | P08173_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | n/a | |
| 6 | P08173_EDT | EDT | DB00974 | 6049;5232305; | CHEMBL858 | {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID | n/a | |
| 7 | P08173_IUE | IUE | n/a | 11536903 | CHEMBL3770346 | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide | n/a | |
| 8 | P08173_IUI | IUI | n/a | 73774630 | CHEMBL3915634 | 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide | n/a | |
| 9 | P08173_IXO | IXO | n/a | 10104167 | CHEMBL3121473 | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium | n/a | |
| 10 | P08173_OLA | OLA | n/a | 445639 | CHEMBL8659 | OLEIC ACID | n/a | |
| 11 | P08173_OLC | OLC | n/a | 11451146 | n/a | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | n/a | |
| 12 | P08173_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
| 13 | P08173_PG6 | PG6 | DB02580 | 70931 | n/a | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | n/a | |
| 14 | P08173_WEC | WEC | n/a | 16103 | CHEMBL73538 | 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine | n/a | |
| 15 | P08173_XNO | XNO | DB15357 | 60809 | CHEMBL21536 | xanomeline | agonist | |
| 16 | P08173_XTD | XTD | n/a | 25263603 | CHEMBL564720 | {2-amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone | n/a | |
| 17 | P08173_DB00246 | n/a | DB00246 | n/a | n/a | Ziprasidone | antagonist | Ki(nM) = 1600.0 |
| 18 | P08173_DB00334 | n/a | DB00334 | n/a | n/a | Olanzapine | antagonist | Ki(nM) = 13.0 |
| 19 | P08173_DB00342 | n/a | DB00342 | n/a | n/a | Terfenadine | binder | |
| 20 | P08173_DB00363 | n/a | DB00363 | n/a | n/a | Clozapine | partial agonist | Ki(nM) = 13.0 EC50(nM) = 10000.0 |
| 21 | P08173_DB00376 | n/a | DB00376 | n/a | n/a | Trihexyphenidyl | antagonist | Ki(nM) = 0.83 IC50(nM) = 6.7 |
| 22 | P08173_DB00387 | n/a | DB00387 | n/a | n/a | Procyclidine | antagonist | Ki(nM) = 7.0 |
| 23 | P08173_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | binder | Ki(nM) = 300.0 |
| 24 | P08173_CCE | CCE | DB00411 | 2551 | CHEMBL965 | Carbamoylcholine | agonist | Ki(nM) = 24.0 IC50(nM) = 0.4 EC50(nM) = 45.0 |
| 25 | P08173_HYO | HYO | DB00424 | n/a | CHEMBL1331216 | Hyoscyamine | antagonist | |
| 26 | P08173_IXX | IXX | DB00458 | 3696 | CHEMBL11 | Imipramine | antagonist | Ki(nM) = 112.0 |
| 27 | P08173_DB00496 | n/a | DB00496 | n/a | n/a | Darifenacin | antagonist | Ki(nM) = 8.6 |
| 28 | P08173_DB00572 | n/a | DB00572 | n/a | n/a | Atropine | antagonist | Ki(nM) = 1.39 |
| 29 | P08173_DB00622 | n/a | DB00622 | n/a | n/a | Nicardipine | antagonist | |
| 30 | P08173_DB00725 | n/a | DB00725 | n/a | n/a | Homatropine methylbromide | antagonist | |
| 31 | P08173_DB00747 | n/a | DB00747 | n/a | n/a | Scopolamine | antagonist | |
| 32 | P08173_DB00767 | n/a | DB00767 | n/a | n/a | Benzquinamide | antagonist | |
| 33 | P08173_DB00809 | n/a | DB00809 | n/a | n/a | Tropicamide | antagonist | Ki(nM) = 3.47 |
| 34 | P08173_DB00835 | n/a | DB00835 | n/a | n/a | Brompheniramine | antagonist | |
| 35 | P08173_DB00934 | n/a | DB00934 | n/a | n/a | Maprotiline | antagonist | |
| 36 | P08173_DB00940 | n/a | DB00940 | n/a | n/a | Methantheline | n/a | |
| 37 | P08173_DB00986 | n/a | DB00986 | n/a | n/a | Glycopyrronium | antagonist | IC50(nM) = 0.158 |
| 38 | P08173_DB01019 | n/a | DB01019 | n/a | n/a | Bethanechol | agonist | |
| 39 | P08173_DB01036 | n/a | DB01036 | n/a | n/a | Tolterodine | antagonist | Ki(nM) = 3.1 |
| 40 | P08173_DB01069 | n/a | DB01069 | n/a | n/a | Promethazine | antagonist | |
| 41 | P08173_9PL | 9PL | DB01085 | 5910 | CHEMBL550 | Pilocarpine | partial agonist | |
| 42 | P08173_DB01142 | no_lig_id | DB01142 | n/a | n/a | Doxepin | antagonist | |
| 43 | P08173_DSM | DSM | DB01151 | 2995 | CHEMBL72 | Desipramine | antagonist | Ki(nM) = 160.0 |
| 44 | P08173_DB01224 | n/a | DB01224 | n/a | n/a | Quetiapine | ligand | Ki(nM) = 126.0 |
| 45 | P08173_9SC | 9SC | DB01238 | 60795 | CHEMBL1112 | Aripiprazole | ligand | Ki(nM) = 1520.0 |
| 46 | P08173_DB01239 | n/a | DB01239 | n/a | n/a | Chlorprothixene | antagonist | |
| 47 | P08173_DB01403 | n/a | DB01403 | n/a | n/a | Methotrimeprazine | antagonist | |
| 48 | P08173_DB01591 | n/a | DB01591 | n/a | n/a | Solifenacin | antagonist | Ki(nM) = 129.0 |
| 49 | P08173_DB01625 | n/a | DB01625 | n/a | n/a | Isopropamide | antagonist | |
| 50 | P08173_DB06702 | n/a | DB06702 | n/a | n/a | Fesoterodine | antagonist | |
| 51 | P08173_DB06709 | n/a | DB06709 | n/a | n/a | Methacholine | agonist | Ki(nM) = 1600.0 |
| 52 | P08173_DB06787 | n/a | DB06787 | n/a | n/a | Hexocyclium | antagonist | |
| 53 | P08173_DB08897 | n/a | DB08897 | n/a | n/a | Aclidinium | antagonist | IC50(nM) = 0.2 |
| 54 | P08173_DB09076 | n/a | DB09076 | n/a | n/a | Umeclidinium | antagonist | |
| 55 | P08173_DB09089 | n/a | DB09089 | n/a | n/a | Trimebutine | antagonist | |
| 56 | P08173_DB09167 | n/a | DB09167 | n/a | n/a | Dosulepin | antagonist | |
| 57 | P08173_DB09185 | n/a | DB09185 | n/a | n/a | Viloxazine | antagonist | |
| 58 | P08173_DB11181 | n/a | DB11181 | n/a | n/a | Homatropine | antagonist | |
| 59 | P08173_DB11235 | n/a | DB11235 | n/a | n/a | Thonzylamine | antagonist | |
| 60 | P08173_DB12278 | n/a | DB12278 | n/a | n/a | Propiverine | antagonist | |
| 61 | P08173_DB13581 | n/a | DB13581 | n/a | n/a | Rociverine | antagonist | |
| 62 | P08173_DB14185 | n/a | DB14185 | n/a | n/a | Aripiprazole lauroxil | n/a |