Gene name: NR3C2
Protein name: Mineralocorticoid receptor (MR)
List of molecules and drugs that interact with protein P08235
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08235_1CA | 1CA | n/a | 6166 | CHEMBL1498 | DESOXYCORTICOSTERONE | n/a | |
| 2 | P08235_60R | 60R | n/a | 118796369 | CHEMBL3775752 | 6-[(~{E})-(3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene)methyl]-4~{H}-1,4-benzoxazin-3-one | n/a | |
| 3 | P08235_6Q0 | 6Q0 | n/a | 122705803 | n/a | ~{N}-[[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]methyl]benzenesulfonamide | n/a | |
| 4 | P08235_6QE | 6QE | n/a | 122705804 | n/a | ~{N}-[[4-[5-[[2,3-bis(fluoranyl)phenoxy]methyl]-3-methyl-1,2-oxazol-4-yl]phenyl]methyl]-1-methyl-cyclopropane-1-sulfonamide | n/a | |
| 5 | P08235_6QG | 6QG | n/a | 137348511 | n/a | 3-methyl-5,8-dioxa-17lambda-thia-4,18-diazatetracyclo[18.2.2.1,.0]pentacosa-1(22),2(6),3,9,11,13(25),20,23-octaene-17,17-dione | n/a | |
| 6 | P08235_AS4 | AS4 | DB04630 | 5839 | CHEMBL273453 | ALDOSTERONE | agonist | IC50(nM) = 0.305 Kd(nM) = 0.5 EC50(nM) = 0.18 |
| 7 | P08235_BOG | BOG | n/a | 62852 | CHEMBL446037 | octyl beta-D-glucopyranoside | n/a | |
| 8 | P08235_C0R | C0R | DB04652 | 5753 | CHEMBL110739 | CORTICOSTERONE | inhibitor | Kd(nM) = 0.5 |
| 9 | P08235_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 10 | P08235_CV7 | CV7 | n/a | 6918281 | CHEMBL4594374 | DESISOBUYTYRYL CICLESONIDE | n/a | |
| 11 | P08235_DEX | DEX | DB01234 | 5743 | CHEMBL384467 | DEXAMETHASONE | n/a | Ki(nM) = 0.36 IC50(nM) = 33.0 |
| 12 | P08235_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 13 | P08235_E6R | E6R | DB15207 | 25052023 | CHEMBL2181932 | 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide | n/a | |
| 14 | P08235_ECV | ECV | DB15418 | 118599727 | CHEMBL3916929 | 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide | n/a | |
| 15 | P08235_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 16 | P08235_EWN | EWN | n/a | 135567449 | CHEMBL4468672 | 6-[[(3~{S})-7-fluoranyl-3-(2-methylpropyl)-2,3-dihydro-1,4-benzoxazin-4-yl]carbonyl]-4~{H}-1,4-benzoxazin-3-one | n/a | |
| 17 | P08235_EY8 | EY8 | n/a | 135567451 | CHEMBL4532472 | [(3~{R})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]methanesulfonamide | n/a | |
| 18 | P08235_EYN | EYN | n/a | 135567452 | CHEMBL4555842 | 2-[(3~{S})-7-fluoranyl-6-(2-methylpropyl)-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide | n/a | |
| 19 | P08235_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 20 | P08235_HFN | HFN | n/a | 59281403 | CHEMBL3337829 | 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one | n/a | |
| 21 | P08235_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 22 | P08235_LD1 | LD1 | n/a | 54751696 | n/a | 6-[(7S)-7-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-2H-1,4-benzoxazin-3(4H)-one | n/a | |
| 23 | P08235_LD2 | LD2 | n/a | 137349686 | n/a | 6-[(1E)-2-phenyl-N-(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]-2H-1,4-benzoxazin-3(4H)-one | n/a | |
| 24 | P08235_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 25 | P08235_NHE | NHE | DB03309 | 66898;3852474; | n/a | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | n/a | |
| 26 | P08235_PDN | PDN | DB00635 | 5289127 | n/a | 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE | n/a | |
| 27 | P08235_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 28 | P08235_SNL | SNL | DB00421 | 5833 | CHEMBL1393 | SPIRONOLACTONE | antagonist | Ki(nM) = 2.323 IC50(nM) = 1.6 |
| 29 | P08235_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 30 | P08235_WFF | WFF | n/a | 72163477 | CHEMBL2419303 | 6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one | n/a | |
| 31 | P08235_WFG | WFG | n/a | 71660626 | n/a | 6-[(2S)-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one | n/a | |
| 32 | P08235_YNU | YNU | DB00700 | 443872 | CHEMBL1095097 | eplerenone | antagonist | Ki(nM) = 126.0 IC50(nM) = 63.0 EC50(nM) = 100.0 |
| 33 | P08235_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 34 | P08235_STR | STR | DB00396 | 5994 | CHEMBL103 | PROGESTERONE | antagonist | IC50(nM) = 14.0 Kd(nM) = 0.39 |
| 35 | P08235_DB00393 | n/a | DB00393 | n/a | n/a | Nimodipine | antagonist | |
| 36 | P08235_DB00588 | n/a | DB00588 | n/a | n/a | Fluticasone propionate | antagonist | IC50(nM) = 149.0 |
| 37 | P08235_TES | TES | DB00624 | 6013 | CHEMBL386630 | Testosterone | ligand | |
| 38 | P08235_ZK5 | ZK5 | DB00687 | 31378 | CHEMBL1201388 | Fludrocortisone | agonist | |
| 39 | P08235_XRD | XRD | DB01013 | 32798 | CHEMBL1159650 | Clobetasol propionate | agonist | |
| 40 | P08235_DB01023 | n/a | DB01023 | n/a | n/a | Felodipine | antagonist | |
| 41 | P08235_DB01134 | n/a | DB01134 | n/a | n/a | Desoxycorticosterone pivalate | agonist | |
| 42 | P08235_DB01395 | n/a | DB01395 | n/a | n/a | Drospirenone | antagonist | IC50(nM) = 3.3 |
| 43 | P08235_DHT | DHT | DB02901 | 10635 | CHEMBL27769 | Stanolone | n/a | |
| 44 | P08235_R18 | R18 | DB02998 | 261000 | CHEMBL166444 | Metribolone | n/a | Ki(nM) = 0.54 |
| 45 | P08235_DB06780 | n/a | DB06780 | n/a | n/a | Desoxycorticosterone acetate | agonist | |
| 46 | P08235_GW6 | GW6 | DB08906 | 9854489 | CHEMBL1676 | Fluticasone furoate | antagonist | IC50(nM) = 166.0 EC50(nM) = 3000.0 |
| 47 | P08235_DB13867 | n/a | DB13867 | n/a | n/a | Fluticasone | antagonist | |
| 48 | P08235_DB13943 | n/a | DB13943 | n/a | n/a | Testosterone cypionate | n/a | |
| 49 | P08235_DB13944 | n/a | DB13944 | n/a | n/a | Testosterone enanthate | n/a | |
| 50 | P08235_DB13951 | n/a | DB13951 | n/a | n/a | Stanolone acetate | n/a | |
| 51 | P08235_DB16165 | n/a | DB16165 | n/a | n/a | Finerenone | antagonist |