Gene name: MMP3
Protein name: Stromelysin-1 (SL-1) (EC
List of molecules and drugs that interact with protein P08254
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08254_0DS | 0DS | n/a | 5496920 | CHEMBL93890 | N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-L-leucyl-L-phenylalaninamide | n/a | |
| 2 | P08254_111 | 111 | DB02367 | 5287415 | CHEMBL358064 | (1N)-4-N-BUTOXYPHENYLSULFONYL-(2R)-N-HYDROXYCARBOXAMIDO-(4S)-METHANESULFONYLAMINO-PYRROLIDINE | n/a | IC50(nM) = 16.0 |
| 3 | P08254_3MP | 3MP | DB01996 | 7970 | CHEMBL15722 | 3-METHYLPYRIDINE | inhibitor | |
| 4 | P08254_8MI | 8MI | DB02747 | 5288637 | n/a | N-(R-CARBOXY-ETHYL)-ALPHA-(S)-(2-PHENYLETHYL)GLYCYL-L-ARGININE-N-PHENYLAMIDE | n/a | |
| 5 | P08254_ATT | ATT | DB07390 | 449486;4369084; | CHEMBL249847 | 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE | inhibitor | Ki(nM) = 708.0 |
| 6 | P08254_BBH | BBH | DB04140 | 445018 | CHEMBL7390 | 1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE | n/a | IC50(nM) = 3.1 |
| 7 | P08254_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 8 | P08254_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 9 | P08254_DPS | DPS | DB02449 | 444789 | CHEMBL91649 | 3-(1H-INDOL-3-YL)-2-[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-PROPIONIC ACID | n/a | |
| 10 | P08254_FA4 | FA4 | n/a | 6914601 | n/a | SM-25453 | n/a | |
| 11 | P08254_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 12 | P08254_HAV | HAV | DB02697 | 444599 | n/a | HYDROXYAMINOVALINE | inhibitor | |
| 13 | P08254_HQQ | HQQ | DB03368 | 1836 | CHEMBL176467 | 5-METHYL-5-(4-PHENOXY-PHENYL)-PYRIMIDINE-2,4,6-TRIONE | n/a | IC50(nM) = 2000.0 |
| 14 | P08254_IN7 | IN7 | DB07986 | 1948 | n/a | [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID | n/a | |
| 15 | P08254_IN8 | IN8 | DB07987 | 449412;4369082; | n/a | [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER | n/a | |
| 16 | P08254_IN9 | IN9 | DB07988 | 448934;4369080; | CHEMBL290140 | 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE | inhibitor | Ki(nM) = 18.0 |
| 17 | P08254_JT5 | JT5 | DB08029 | 24178109 | CHEMBL1233772 | N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide | n/a | |
| 18 | P08254_JT6 | JT6 | DB08030 | 10039403 | CHEMBL38851 | 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide | n/a | IC50(nM) = 25.0 Kd(nM) = 100.0 |
| 19 | P08254_L04 | L04 | n/a | 446065 | CHEMBL8933 | 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHYL-1-PHENYLCARBAMOYL-BUTYLCARBAMOYL)-2-[4-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BUTYL]-HEXANOIC ACID | n/a | |
| 20 | P08254_MBS | MBS | DB04416 | 446165 | n/a | R-2-{[4'-METHOXY-(1,1'-BIPHENYL)-4-YL]-SULFONYL}-AMINO-6-METHOXY-HEX-4-YNOIC ACID | n/a | |
| 21 | P08254_MM3 | MM3 | DB02350 | 5288814 | CHEMBL1234370 | N-HYDROXY-4-[(4-METHOXYLPHENYL)SULFONYL]-2,2-DIMETHYL-HEXAHYDRO-1,4-THIAZEPINE-3(S)-CARBOXAMIDE | n/a | |
| 22 | P08254_MSB | MSB | DB03033 | 5171961 | n/a | 1-METHYLOXY-4-SULFONE-BENZENE | inhibitor | |
| 23 | P08254_N25 | N25 | n/a | 4218 | CHEMBL115727 | 1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC ACID HYDROXYAMIDE | n/a | |
| 24 | P08254_NGH | NGH | DB08271 | 448002 | CHEMBL311932 | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID | n/a | Ki(nM) = 132.0 IC50(nM) = 6500.0 |
| 25 | P08254_OHL | OHL | n/a | 10831751 | CHEMBL315949 | N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]-N~2~-(pyridin-4-ylmethyl)glycinamide | n/a | |
| 26 | P08254_PT | PT | n/a | 105166 | n/a | PLATINUM (II) ION | n/a | |
| 27 | P08254_S27 | S27 | DB08507 | 9543420 | CHEMBL176602 | N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID | n/a | IC50(nM) = 24.0 |
| 28 | P08254_S80 | S80 | DB02090 | 17754156 | n/a | N1-HYDROXY-2-(3-HYDROXY-PROPYL)-3-ISOBUTYL-N4-[1-(2-METHOXY-ETHYL)-2-OXO-AZEPAN-3-YL]-SUCCINAMIDE | n/a | |
| 29 | P08254_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 30 | P08254_TR1 | TR1 | DB08643 | 4369141 | n/a | 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER | n/a | |
| 31 | P08254_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 32 | P08254_Z79 | Z79 | n/a | 10445302 | CHEMBL83508 | N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]glycinamide | n/a | |
| 33 | P08254_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 34 | P08254_SPC | SPC | DB01877 | 17754173 | n/a | N-HYDROXY 1N(4-METHOXYPHENYL)SULFONYL-4-(Z,E-N-METHOXYIMINO)PYRROLIDINE-2R-CARBOXAMIDE | n/a | |
| 35 | P08254_SPI | SPI | DB04232 | 5289389 | n/a | N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYL-PIPERAZINE-2-CARBOXAMIDE | n/a | |
| 36 | P08254_097 | 097 | DB00786 | 119031 | CHEMBL279785 | Marimastat | antagonist | Ki(nM) = 2.4 IC50(nM) = 4.4 |