Gene name: MME
Protein name: Neprilysin (EC 3.4.24.11)
List of molecules and drugs that interact with protein P08473
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08473_6LD | 6LD | DB14127 | 10430040 | CHEMBL417007 | Sacubitrilat | inhibitor | |
| 2 | P08473_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 3 | P08473_BIR | BIR | DB02062 | 5478838;58263406; | n/a | N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE | n/a | |
| 4 | P08473_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 5 | P08473_D0W | D0W | n/a | 132451821 | CHEMBL4462603 | Sampatrilat-Asp | n/a | |
| 6 | P08473_D0Z | D0Z | n/a | 6324648 | CHEMBL42583 | Sampatrilat | n/a | |
| 7 | P08473_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 8 | P08473_FT8 | FT8 | DB00886 | 656629 | CHEMBL289556 | Omapatrilat | modulator | |
| 9 | P08473_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 10 | P08473_HA0 | HA0 | n/a | 52914843 | n/a | HETEROARYLALANINE 5-PHENYL OXAZOLE | n/a | |
| 11 | P08473_I20 | I20 | n/a | 49867138 | n/a | (2S)-2-({(2S)-3-[(R)-[(1R)-1-({(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-5-oxopentanoyl}amino)ethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}amino)propanoic acid | n/a | |
| 12 | P08473_N9Q | N9Q | n/a | 59607741 | CHEMBL3676150 | 4-[[(2~{R})-1-[4-(3-chlorophenyl)phenyl]-4-oxidanyl-4-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butanoic acid | n/a | |
| 13 | P08473_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 14 | P08473_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 15 | P08473_OIR | OIR | DB02558 | 448249 | n/a | N-(3-PHENYL-2-SULFANYLPROPANOYL)PHENYLALANYLALANINE | n/a | |
| 16 | P08473_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 17 | P08473_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 18 | P08473_RDF | RDF | DB02557 | 445114 | CHEMBL479579 | N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN | inhibitor | |
| 19 | P08473_TI1 | TI1 | DB02597 | 5289469 | n/a | [2(R,S)-2-SULFANYLHEPTANOYL]-PHE-ALA | inhibitor | |
| 20 | P08473_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 21 | P08473_STS | STS | DB08575 | 5289417 | n/a | 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM | n/a | |
| 22 | P08473_DB00616 | n/a | DB00616 | n/a | n/a | Candoxatril | inhibitor | |
| 23 | P08473_DB05796 | n/a | DB05796 | n/a | n/a | Daglutril | modulator | |
| 24 | P08473_TIO | TIO | DB08626 | 4369380 | CHEMBL298827 | Thiorphan | inhibitor | Ki(nM) = 1.5 IC50(nM) = 20.0 |
| 25 | P08473_DB09292 | n/a | DB09292 | n/a | n/a | Sacubitril | antagonist | |
| 26 | P08473_DB11623 | n/a | DB11623 | n/a | n/a | Candoxatrilat | inhibitor |