Gene name: ADRB1
Protein name: Beta-1 adrenergic receptor
List of molecules and drugs that interact with protein P08588
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08588_SPM | SPM | DB00127 | 1103 | CHEMBL23194 | Spermine | n/a | |
| 2 | P08588_DB00187 | n/a | DB00187 | n/a | n/a | Esmolol | antagonist | |
| 3 | P08588_DB00195 | n/a | DB00195 | n/a | n/a | Betaxolol | antagonist | IC50(nM) = 37.0 |
| 4 | P08588_DB00221 | n/a | DB00221 | n/a | n/a | Isoetharine | agonist | |
| 5 | P08588_DB00243 | n/a | DB00243 | n/a | n/a | Ranolazine | antagonist | |
| 6 | P08588_DB00248 | n/a | DB00248 | n/a | n/a | Cabergoline | binder | |
| 7 | P08588_DB00264 | n/a | DB00264 | n/a | n/a | Metoprolol | inhibitor | Ki(nM) = 47.0 Kd(nM) = 55.0 |
| 8 | P08588_DB00335 | n/a | DB00335 | n/a | n/a | Atenolol | antagonist | Ki(nM) = 170.0 IC50(nM) = 210.0 Kd(nM) = 219.0 |
| 9 | P08588_LNR | LNR | DB00368 | 439260 | CHEMBL1437 | Norepinephrine | agonist | EC50(nM) = 2600.0 |
| 10 | P08588_TIM | TIM | DB00373 | 33624 | CHEMBL499 | Timolol | antagonist | Kd(nM) = 5.35 |
| 11 | P08588_DB00397 | n/a | DB00397 | n/a | n/a | Phenylpropanolamine | agonist | |
| 12 | P08588_DB00408 | n/a | DB00408 | n/a | n/a | Loxapine | binder | |
| 13 | P08588_DB00489 | n/a | DB00489 | n/a | n/a | Sotalol | antagonist | IC50(nM) = 7200.0 Kd(nM) = 1698.0 |
| 14 | P08588_DB00521 | n/a | DB00521 | n/a | n/a | Carteolol | antagonist | Ki(nM) = 1.9 |
| 15 | P08588_DB00555 | n/a | DB00555 | n/a | n/a | Lamotrigine | inhibitor | |
| 16 | P08588_DB00571 | n/a | DB00571 | n/a | n/a | Propranolol | antagonist | Ki(nM) = 0.02 IC50(nM) = 4.0 Kd(nM) = 1.8 |
| 17 | P08588_DB00598 | n/a | DB00598 | n/a | n/a | Labetalol | antagonist | Kd(nM) = 23.5 |
| 18 | P08588_DB00612 | n/a | DB00612 | n/a | n/a | Bisoprolol | antagonist | Ki(nM) = 22.4 Kd(nM) = 15.0 |
| 19 | P08588_ALE | ALE | DB00668 | 5816;139148732; | CHEMBL679 | Epinephrine | agonist | EC50(nM) = 290.0 |
| 20 | P08588_DB00841 | n/a | DB00841 | n/a | n/a | Dobutamine | agonist | |
| 21 | P08588_DB00852 | n/a | DB00852 | n/a | n/a | Pseudoephedrine | agonist | |
| 22 | P08588_DB00866 | n/a | DB00866 | n/a | n/a | Alprenolol | antagonist | Ki(nM) = 2.8 IC50(nM) = 2.3 Kd(nM) = 4.3 |
| 23 | P08588_DB00871 | n/a | DB00871 | n/a | n/a | Terbutaline | antagonist | Ki(nM) = 10000.0 Kd(nM) = 151356.0 |
| 24 | P08588_DB00938 | n/a | DB00938 | n/a | n/a | Salmeterol | inverse agonist | Ki(nM) = 784.0 IC50(nM) = 501.0 Kd(nM) = 4169.0 EC50(nM) = 67.0 |
| 25 | P08588_DB00960 | n/a | DB00960 | n/a | n/a | Pindolol | partial agonist | Ki(nM) = 0.52 Kd(nM) = 2.4 |
| 26 | P08588_DB00983 | n/a | DB00983 | n/a | n/a | Formoterol | agonist | Ki(nM) = 315.0 IC50(nM) = 631.0 EC50(nM) = 13.0 |
| 27 | P08588_DB01001 | n/a | DB01001 | n/a | n/a | Salbutamol | agonist | Ki(nM) = 2440.0 Kd(nM) = 21878.0 EC50(nM) = 1.5 |
| 28 | P08588_DB01064 | n/a | DB01064 | n/a | n/a | Isoprenaline | agonist | Ki(nM) = 224.0 EC50(nM) = 0.084 |
| 29 | P08588_DB01102 | n/a | DB01102 | n/a | n/a | Arbutamine | agonist | |
| 30 | P08588_DB01136 | n/a | DB01136 | n/a | n/a | Carvedilol | antagonist | Ki(nM) = 1.7 Kd(nM) = 1.76 |
| 31 | P08588_DSM | DSM | DB01151 | 2995 | CHEMBL72 | Desipramine | other | |
| 32 | P08588_DB01182 | n/a | DB01182 | n/a | n/a | Propafenone | antagonist | |
| 33 | P08588_DB01193 | n/a | DB01193 | n/a | n/a | Acebutolol | partial agonist | Kd(nM) = 347.0 |
| 34 | P08588_DB01203 | n/a | DB01203 | n/a | n/a | Nadolol | antagonist | Kd(nM) = 59.0 |
| 35 | P08588_DB01210 | n/a | DB01210 | n/a | n/a | Levobunolol | antagonist | |
| 36 | P08588_DB01214 | n/a | DB01214 | n/a | n/a | Metipranolol | antagonist | |
| 37 | P08588_9SC | 9SC | DB01238 | 60795 | CHEMBL1112 | Aripiprazole | ligand | Ki(nM) = 141.0 |
| 38 | P08588_DB01288 | n/a | DB01288 | n/a | n/a | Fenoterol | agonist | Ki(nM) = 10000.0 |
| 39 | P08588_DB01291 | n/a | DB01291 | n/a | n/a | Pirbuterol | agonist | |
| 40 | P08588_DB01295 | n/a | DB01295 | n/a | n/a | Bevantolol | antagonist | |
| 41 | P08588_DB01297 | n/a | DB01297 | n/a | n/a | Practolol | antagonist | Kd(nM) = 724.0 |
| 42 | P08588_DB01359 | n/a | DB01359 | n/a | n/a | Penbutolol | antagonist | |
| 43 | P08588_DB01364 | n/a | DB01364 | n/a | n/a | Ephedrine | agonist | |
| 44 | P08588_DB01407 | n/a | DB01407 | n/a | n/a | Clenbuterol | agonist | |
| 45 | P08588_DB01580 | n/a | DB01580 | n/a | n/a | Oxprenolol | antagonist | |
| 46 | P08588_PUT | PUT | DB01917 | 1045 | CHEMBL46257 | Putrescine | n/a | |
| 47 | P08588_SPD | SPD | DB03566 | 1102 | CHEMBL19612 | Spermidine | n/a | |
| 48 | P08588_DB04846 | n/a | DB04846 | n/a | n/a | Celiprolol | antagonist | |
| 49 | P08588_DB04855 | n/a | DB04855 | n/a | n/a | Dronedarone | antagonist | |
| 50 | P08588_DB04861 | n/a | DB04861 | n/a | n/a | Nebivolol | antagonist | |
| 51 | P08588_DB06216 | n/a | DB06216 | n/a | n/a | Asenapine | antagonist | Ki(nM) = 5000.0 |
| 52 | P08588_DB06262 | n/a | DB06262 | n/a | n/a | Droxidopa | agonist | |
| 53 | P08588_P32 | P32 | DB08347 | 46937143 | n/a | 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile | n/a | |
| 54 | P08588_SOG | SOG | DB08558 | 656909 | n/a | 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL | n/a | |
| 55 | P08588_DB08807 | n/a | DB08807 | n/a | n/a | Bopindolol | antagonist | |
| 56 | P08588_DB08808 | n/a | DB08808 | n/a | n/a | Bupranolol | antagonist | Kd(nM) = 3.1 |
| 57 | P08588_H6U | H6U | DB08893 | 9865528 | CHEMBL2095212 | Mirabegron | agonist | |
| 58 | P08588_DB09013 | n/a | DB09013 | n/a | n/a | Befunolol | n/a | |
| 59 | P08588_DB09068 | n/a | DB09068 | n/a | n/a | Vortioxetine | ligand | |
| 60 | P08588_DB09204 | n/a | DB09204 | n/a | n/a | Arotinolol | antagonist | |
| 61 | P08588_DB09351 | n/a | DB09351 | n/a | n/a | Levobetaxolol | antagonist | |
| 62 | P08588_DB11278 | n/a | DB11278 | n/a | n/a | DL-Methylephedrine | agonist | |
| 63 | P08588_DB13781 | n/a | DB13781 | n/a | n/a | Xamoterol | partial agonist |