Gene name: HCK
Protein name: Tyrosine-protein kinase HCK
List of molecules and drugs that interact with protein P08631
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P08631_1BM | 1BM | n/a | 9547983 | CHEMBL434369 | 3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL | n/a | |
| 2 | P08631_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 3 | P08631_B43 | B43 | n/a | 6603792 | CHEMBL47940 | 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | n/a | |
| 4 | P08631_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 5 | P08631_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 6 | P08631_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 7 | P08631_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
| 8 | P08631_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 9 | P08631_KS1 | KS1 | DB08052 | 24905142 | CHEMBL1081312 | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | inhibitor | |
| 10 | P08631_L1G | L1G | n/a | n/a | CHEMBL314627 | N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE | n/a | |
| 11 | P08631_L2G | L2G | n/a | n/a | CHEMBL197603 | N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE | n/a | |
| 12 | P08631_L3G | L3G | n/a | 9549185 | CHEMBL381203 | N-(4-{4-AMINO-1-[1-(TETRAHYDRO-2H-PYRAN-4-YL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE | n/a | |
| 13 | P08631_OOO | OOO | n/a | n/a | n/a | ethyl (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate | n/a | |
| 14 | P08631_OOQ | OOQ | n/a | n/a | CHEMBL4208669 | (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate | n/a | |
| 15 | P08631_OOS | OOS | n/a | n/a | CHEMBL4065334 | (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide | n/a | |
| 16 | P08631_OOU | OOU | n/a | n/a | CHEMBL4085262 | (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},4-dimethyl-pentanamide | n/a | |
| 17 | P08631_OOV | OOV | n/a | n/a | CHEMBL4103186 | (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},~{N},4-trimethyl-pentanamide | n/a | |
| 18 | P08631_PP1 | PP1 | DB01809 | 1400 | CHEMBL306380 | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | n/a | |
| 19 | P08631_QUE | QUE | DB04216 | 5280343 | CHEMBL50 | 3,5,7,3',4'-PENTAHYDROXYFLAVONE | n/a | |
| 20 | P08631_SK8 | SK8 | n/a | 5228 | CHEMBL313417 | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole | n/a | |
| 21 | P08631_VRZ | VRZ | n/a | 71305027 | n/a | 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea | n/a | |
| 22 | P08631_VS0 | VS0 | n/a | 71305028 | n/a | N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | n/a | |
| 23 | P08631_VSA | VSA | n/a | 71305029 | n/a | 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | n/a | |
| 24 | P08631_VSB | VSB | n/a | n/a | CHEMBL47203 | 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 25 | P08631_VSE | VSE | n/a | n/a | CHEMBL45177 | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 26 | P08631_VSF | VSF | n/a | 22736361 | CHEMBL296103 | 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 27 | P08631_VSG | VSG | n/a | 71305032 | n/a | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 28 | P08631_VSH | VSH | n/a | 24905150 | CHEMBL1241481 | tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | n/a | |
| 29 | P08631_PTR | PTR | DB01962 | 30819 | CHEMBL286939 | Phosphonotyrosine | n/a | |
| 30 | P08631_DB8 | DB8 | DB06616 | 5328940 | CHEMBL288441 | Bosutinib | inhibitor | IC50(nM) = 3.2 Kd(nM) = 3.4 |
| 31 | P08631_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |