Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P08908 5HT1A_HUMAN
Gene name: HTR1A
Protein name: 5-hydroxytryptamine receptor 1A

List of molecules and drugs that interact with protein P08908

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P08908_UJL UJL DB15665 89532783 CHEMBL4650337 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine agonist
2 P08908_DB00216 n/a DB00216 n/a n/a Eletriptan agonist
3 P08908_DB00246 n/a DB00246 n/a n/a Ziprasidone agonist Ki(nM) = 1.6
4 P08908_DB00247 n/a DB00247 n/a n/a Methysergide agonist
5 P08908_DB00248 n/a DB00248 n/a n/a Cabergoline agonist
6 P08908_DB00315 n/a DB00315 n/a n/a Zolmitriptan agonist Ki(nM) = 79.0
Kd(nM) = 1.8
7 P08908_2GM 2GM DB00320 10531 CHEMBL1732 Dihydroergotamine agonist
8 P08908_TP0 TP0 DB00321 2160 CHEMBL629 Amitriptyline inhibitor Ki(nM) = 450.0
9 P08908_DB00363 n/a DB00363 n/a n/a Clozapine antagonist Ki(nM) = 6.4
IC50(nM) = 150.0
10 P08908_DB00408 n/a DB00408 n/a n/a Loxapine binder Ki(nM) = 2456.0
11 P08908_G6L G6L DB00413 119570 CHEMBL301265 Pramipexole agonist Ki(nM) = 6514.0
12 P08908_DB00422 n/a DB00422 n/a n/a Methylphenidate n/a
13 P08908_IXX IXX DB00458 3696 CHEMBL11 Imipramine activator Ki(nM) = 5800.0
14 P08908_Z80 Z80 DB00477 2726 CHEMBL71 Chlorpromazine antagonist Ki(nM) = 116.4
15 P08908_DB00490 n/a DB00490 n/a n/a Buspirone partial agonist Ki(nM) = 3.1
IC50(nM) = 25.0
EC50(nM) = 15.0
16 P08908_GMJ GMJ DB00502 3559 CHEMBL54 Haloperidol n/a Ki(nM) = 1202.0
IC50(nM) = 1500.0
17 P08908_21B 21B DB00540 4543 CHEMBL445 Nortriptyline antagonist Ki(nM) = 294.0
18 P08908_DB00543 n/a DB00543 n/a n/a Amoxapine antagonist Ki(nM) = 221.0
19 P08908_DB00571 n/a DB00571 n/a n/a Propranolol other/unknown Ki(nM) = 31.0
IC50(nM) = 3981.0
20 P08908_DB00574 n/a DB00574 n/a n/a Fenfluramine agonist
21 P08908_H8G H8G DB00589 28864 CHEMBL157138 Lisuride agonist Ki(nM) = 0.3
Kd(nM) = 501.0
22 P08908_DB00656 n/a DB00656 n/a n/a Trazodone antagonist Ki(nM) = 96.0
EC50(nM) = 785.0
23 P08908_DB00669 n/a DB00669 n/a n/a Sumatriptan agonist Ki(nM) = 230.0
IC50(nM) = 398.0
Kd(nM) = 3162.0
EC50(nM) = 1000.0
24 P08908_ERM ERM DB00696 8223 CHEMBL442 Ergotamine agonist
25 P08908_OR9 OR9 DB00714 6005 CHEMBL53 Apomorphine agonist Ki(nM) = 117.0
26 P08908_DB00726 n/a DB00726 n/a n/a Trimipramine antagonist
27 P08908_DB00734 n/a DB00734 n/a n/a Risperidone antagonist Ki(nM) = 21.0
EC50(nM) = 10000.0
28 P08908_DB00866 n/a DB00866 n/a n/a Alprenolol antagonist
29 P08908_S87 S87 DB00904 4595 CHEMBL46 Ondansetron other/unknown Ki(nM) = 10000.0
30 P08908_J5C J5C DB00935 4636 CHEMBL762 Oxymetazoline agonist EC50(nM) = 70.0
31 P08908_DB00952 n/a DB00952 n/a n/a Naratriptan agonist Ki(nM) = 45.0
32 P08908_DB00960 n/a DB00960 n/a n/a Pindolol antagonist Ki(nM) = 15.0
EC50(nM) = 27.0
33 P08908_LDP LDP DB00988 681 CHEMBL59 Dopamine binder Ki(nM) = 8248.0
34 P08908_DB01142 no_lig_id DB01142 n/a n/a Doxepin antagonist
35 P08908_DB01149 n/a DB01149 n/a n/a Nefazodone antagonist Ki(nM) = 80.0
36 P08908_DSM DSM DB01151 2995 CHEMBL72 Desipramine binder Ki(nM) = 6400.0
37 P08908_68P 68P DB01175 146570 CHEMBL1508 Escitalopram inhibitor
38 P08908_DB01186 n/a DB01186 n/a n/a Pergolide agonist Ki(nM) = 1.8
39 P08908_08Y 08Y DB01200 31101 CHEMBL493 Bromocriptine agonist Ki(nM) = 12.88
40 P08908_DB01224 n/a DB01224 n/a n/a Quetiapine antagonist Ki(nM) = 79.0
41 P08908_9SC 9SC DB01238 60795 CHEMBL1112 Aripiprazole partial agonist Ki(nM) = 1.7
EC50(nM) = 24.0
42 P08908_DB01267 n/a DB01267 n/a n/a Paliperidone antagonist Ki(nM) = 480.0
EC50(nM) = 10000.0
43 P08908_DB01359 n/a DB01359 n/a n/a Penbutolol antagonist
44 P08908_DB01392 n/a DB01392 n/a n/a Yohimbine partial agonist Ki(nM) = 50.11
45 P08908_PMZ PMZ DB01614 6077 CHEMBL39560 Acepromazine antagonist
46 P08908_DB01616 n/a DB01616 n/a n/a Alverine antagonist
47 P08908_DB01618 n/a DB01618 n/a n/a Molindone antagonist Ki(nM) = 1204.81
48 P08908_DB01621 n/a DB01621 n/a n/a Pipotiazine antagonist
49 P08908_7LD 7LD DB04829 5761 CHEMBL263881 Lysergic acid diethylamide inhibitor Ki(nM) = 1.09
50 P08908_DB04884 n/a DB04884 n/a n/a Dapoxetine n/a
51 P08908_DB04888 n/a DB04888 n/a n/a Bifeprunox modulator Ki(nM) = 7.19
EC50(nM) = 324.0
52 P08908_DB04908 n/a DB04908 n/a n/a Flibanserin agonist
53 P08908_DB04946 n/a DB04946 n/a n/a Iloperidone antagonist Ki(nM) = 33.0
54 P08908_DB04948 n/a DB04948 n/a n/a Lofexidine agonist Ki(nM) = 126.0
55 P08908_DB04970 n/a DB04970 n/a n/a Lesopitron n/a Ki(nM) = 50.0
56 P08908_DB05271 n/a DB05271 n/a n/a Rotigotine agonist
57 P08908_DB05339 n/a DB05339 n/a n/a MN-305 agonist
58 P08908_DB05562 n/a DB05562 n/a n/a Naluzotan agonist
59 P08908_7RU 7RU DB06016 n/a CHEMBL2028019 Cariprazine partial agonist Ki(nM) = 1.8
60 P08908_DB06148 n/a DB06148 n/a n/a Mianserin blocker
61 P08908_DB06153 n/a DB06153 n/a n/a Pizotifen partial agonist
62 P08908_DB06216 n/a DB06216 n/a n/a Asenapine antagonist Ki(nM) = 10.0
63 P08908_DB06393 n/a DB06393 n/a n/a Xaliproden antagonist
64 P08908_DB06446 n/a DB06446 n/a n/a Dotarizine n/a
65 P08908_DB06454 n/a DB06454 n/a n/a Sarizotan modulator
66 P08908_DB06506 n/a DB06506 n/a n/a Repinotan antagonist
67 P08908_DB06538 n/a DB06538 n/a n/a Robalzotan antagonist
68 P08908_YG7 YG7 DB06684 6918314 CHEMBL439849 Vilazodone agonist Ki(nM) = 0.2
IC50(nM) = 0.11
EC50(nM) = 0.12
69 P08908_DB08807 n/a DB08807 n/a n/a Bopindolol n/a
70 P08908_DB08810 n/a DB08810 n/a n/a Cinitapride agonist
71 P08908_DB08815 n/a DB08815 n/a n/a Lurasidone antagonist Ki(nM) = 6.7
72 P08908_DB08922 n/a DB08922 n/a n/a Perospirone partial agonist
73 P08908_P0T P0T DB09061 644019 CHEMBL190461 Cannabidiol agonist
74 P08908_DB09068 n/a DB09068 n/a n/a Vortioxetine agonist
75 P08908_DB09128 n/a DB09128 n/a n/a Brexpiprazole partial agonist Ki(nM) = 0.12
76 P08908_DB09167 n/a DB09167 n/a n/a Dosulepin antagonist
77 P08908_DB09244 n/a DB09244 n/a n/a Pirlindole antagonist
78 P08908_DB09289 n/a DB09289 n/a n/a Tianeptine inhibitor
79 P08908_DB11755 n/a DB11755 n/a n/a Tetrahydrocannabivarin agonist
80 P08908_DB12061 n/a DB12061 n/a n/a Pardoprunox n/a
81 P08908_DB12540 n/a DB12540 n/a n/a Lecozotan antagonist
82 P08908_DB14010 n/a DB14010 n/a n/a 5-methoxy-N,N-dimethyltryptamine agonist
83 P08908_DB14011 n/a DB14011 n/a n/a Nabiximols n/a
84 P08908_DB14185 n/a DB14185 n/a n/a Aripiprazole lauroxil partial agonist
85 P08908_DB15665 n/a DB15665 n/a n/a SEP-363856 agonist
86 P08908_DB16629 n/a DB16629 n/a n/a Serdexmethylphenidate agonist