P08913 ADA2A_HUMAN
Gene name: ADRA2A
Protein name: Alpha-2A adrenergic receptor

List of molecules and drugs that interact with protein P08913

#	DrugDomain Data	PBD ligand	DrugBank Accession	PubChem	ChEMBL	Name	Drug action	Affinity data
1	P08913_CZX	CZX	DB00633	5311068	CHEMBL778	4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole	agonist
2	P08913_E39	E39	n/a	145704643	n/a	(2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole	n/a
3	P08913_E3F	E3F	n/a	9908992	CHEMBL4303564	(8~{a}~{R},12~{a}~{S},13~{a}~{S})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,11,12~{a},13,13~{a}-decahydroisoquinolino[2,1-g][1,6]naphthyridine	n/a
4	P08913_E5E	E5E	n/a	6921840	n/a	Noradrenaline	n/a
5	P08913_FLC	FLC	n/a	31348	n/a	CITRATE ANION	n/a
6	P08913_J59	J59	DB00484	2435	CHEMBL844	Brimonidine	agonist	Ki(nM) = 1.4 IC50(nM) = 3.0 EC50(nM) = 0.616595
7	P08913_J5C	J5C	DB00935	4636	CHEMBL762	Oxymetazoline	agonist	Ki(nM) = 0.79 EC50(nM) = 3.3
8	P08913_OLA	OLA	n/a	445639	CHEMBL8659	OLEIC ACID	n/a
9	P08913_PEG	PEG	n/a	8117	CHEMBL1235226	DI(HYDROXYETHYL)ETHER	n/a
10	P08913_W58	W58	n/a	164946676	n/a	5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine	n/a
11	P08913_W96	W96	n/a	164946675	n/a	N-pyridin-4-ylisoquinolin-4-amine	n/a
12	P08913_DB00246	n/a	DB00246	n/a	n/a	Ziprasidone	antagonist	Ki(nM) = 154.0
13	P08913_DB00248	n/a	DB00248	n/a	n/a	Cabergoline	antagonist
14	P08913_2GM	2GM	DB00320	10531	CHEMBL1732	Dihydroergotamine	agonist
15	P08913_TP0	TP0	DB00321	2160	CHEMBL629	Amitriptyline	antagonist	Ki(nM) = 114.0
16	P08913_DB00363	n/a	DB00363	n/a	n/a	Clozapine	antagonist	Ki(nM) = 24.0
17	P08913_LNR	LNR	DB00368	439260	CHEMBL1437	Norepinephrine	agonist	Ki(nM) = 30.0 EC50(nM) = 110.0
18	P08913_DB00370	n/a	DB00370	n/a	n/a	Mirtazapine	antagonist	Ki(nM) = 20.0 IC50(nM) = 85.0
19	P08913_DB00408	n/a	DB00408	n/a	n/a	Loxapine	binder	Ki(nM) = 150.8
20	P08913_G6L	G6L	DB00413	119570	CHEMBL301265	Pramipexole	agonist	Ki(nM) = 76.0
21	P08913_DB00449	n/a	DB00449	n/a	n/a	Dipivefrin	agonist
22	P08913_XRA	XRA	DB00457	4893	CHEMBL2	Prazosin	binder	Ki(nM) = 210.0
23	P08913_GMJ	GMJ	DB00502	3559	CHEMBL54	Haloperidol	n/a	Ki(nM) = 600.0
24	P08913_DB00543	n/a	DB00543	n/a	n/a	Amoxapine	antagonist
25	P08913_DB00555	n/a	DB00555	n/a	n/a	Lamotrigine	inhibitor
26	P08913_CLU	CLU	DB00575	2803	CHEMBL134	Clonidine	agonist
27	P08913_H8G	H8G	DB00589	28864	CHEMBL157138	Lisuride	other/unknown	Ki(nM) = 1.8
28	P08913_DB00629	n/a	DB00629	n/a	n/a	Guanabenz	agonist	Ki(nM) = 21.88
29	P08913_DB00656	n/a	DB00656	n/a	n/a	Trazodone	antagonist	Ki(nM) = 106.0
30	P08913_ALE	ALE	DB00668	5816;139148732;	CHEMBL679	Epinephrine	agonist	Ki(nM) = 5.0 IC50(nM) = 8.0 EC50(nM) = 30.0
31	P08913_DB00692	n/a	DB00692	n/a	n/a	Phentolamine	antagonist	Ki(nM) = 1.58
32	P08913_ERM	ERM	DB00696	8223	CHEMBL442	Ergotamine	partial agonist
33	P08913_OR9	OR9	DB00714	6005	CHEMBL53	Apomorphine	agonist	Ki(nM) = 141.25
34	P08913_DB00726	n/a	DB00726	n/a	n/a	Trimipramine	antagonist
35	P08913_DB00751	n/a	DB00751	n/a	n/a	Epinastine	unknown
36	P08913_DB00797	n/a	DB00797	n/a	n/a	Tolazoline	antagonist	Ki(nM) = 24.0
37	P08913_DB00800	n/a	DB00800	n/a	n/a	Fenoldopam	antagonist	Ki(nM) = 16.0
38	P08913_DB00852	n/a	DB00852	n/a	n/a	Pseudoephedrine	agonist
39	P08913_DB00865	n/a	DB00865	n/a	n/a	Benzphetamine	agonist
40	P08913_DB00925	n/a	DB00925	n/a	n/a	Phenoxybenzamine	antagonist
41	P08913_DB00964	n/a	DB00964	n/a	n/a	Apraclonidine	agonist	Ki(nM) = 7.94
42	P08913_DB00968	n/a	DB00968	n/a	n/a	Methyldopa	agonist
43	P08913_DB01018	n/a	DB01018	n/a	n/a	Guanfacine	agonist	Ki(nM) = 50.3
44	P08913_DB01136	n/a	DB01136	n/a	n/a	Carvedilol	antagonist
45	P08913_DB01149	n/a	DB01149	n/a	n/a	Nefazodone	antagonist	Ki(nM) = 84.0
46	P08913_08Y	08Y	DB01200	31101	CHEMBL493	Bromocriptine	agonist	Ki(nM) = 10.96
47	P08913_DB01224	n/a	DB01224	n/a	n/a	Quetiapine	antagonist	Ki(nM) = 80.0
48	P08913_9SC	9SC	DB01238	60795	CHEMBL1112	Aripiprazole	antagonist	Ki(nM) = 74.0
49	P08913_DB01267	n/a	DB01267	n/a	n/a	Paliperidone	antagonist	Ki(nM) = 30.0
50	P08913_DB01392	n/a	DB01392	n/a	n/a	Yohimbine	antagonist	Ki(nM) = 0.32 IC50(nM) = 3.67 Kd(nM) = 2300.0 EC50(nM) = 8.5
51	P08913_DB01403	n/a	DB01403	n/a	n/a	Methotrimeprazine	antagonist
52	P08913_DB01472	n/a	DB01472	n/a	n/a	4-Methoxyamphetamine	agonist
53	P08913_B40	B40	DB01577	10836	CHEMBL1201201	Metamfetamine	agonist
54	P08913_DB01608	n/a	DB01608	n/a	n/a	Periciazine	antagonist
55	P08913_DB01624	n/a	DB01624	n/a	n/a	Zuclopenthixol	antagonist
56	P08913_DB04846	n/a	DB04846	n/a	n/a	Celiprolol	antagonist
57	P08913_DB04855	n/a	DB04855	n/a	n/a	Dronedarone	antagonist
58	P08913_DB04948	n/a	DB04948	n/a	n/a	Lofexidine	agonist	Ki(nM) = 4.4 EC50(nM) = 6.3
59	P08913_NP1	NP1	DB05492	5276854	CHEMBL609728	Epicept NP-1	n/a
60	P08913_DB06148	n/a	DB06148	n/a	n/a	Mianserin	antagonist
61	P08913_DB06153	n/a	DB06153	n/a	n/a	Pizotifen	antagonist
62	P08913_DB06216	n/a	DB06216	n/a	n/a	Asenapine	antagonist	Ki(nM) = 6.5
63	P08913_DB06229	n/a	DB06229	n/a	n/a	Ocaperidone	n/a
64	P08913_DB06262	n/a	DB06262	n/a	n/a	Droxidopa	agonist
65	P08913_DB06623	n/a	DB06623	n/a	n/a	Flupirtine	n/a
66	P08913_DB06694	n/a	DB06694	n/a	n/a	Xylometazoline	agonist	Ki(nM) = 15.14
67	P08913_DB06711	n/a	DB06711	n/a	n/a	Naphazoline	agonist	Ki(nM) = 20.89 IC50(nM) = 0.0011
68	P08913_DB08815	n/a	DB08815	n/a	n/a	Lurasidone	n/a
69	P08913_DB09242	n/a	DB09242	n/a	n/a	Moxonidine	agonist
70	P08913_DB09244	n/a	DB09244	n/a	n/a	Pirlindole	antagonist
71	P08913_DB09286	n/a	DB09286	n/a	n/a	Pipamperone	antagonist	Ki(nM) = 860.0
72	P08913_DB11278	n/a	DB11278	n/a	n/a	DL-Methylephedrine	agonist
73	P08913_DB11738	n/a	DB11738	n/a	n/a	Rilmenidine	n/a
74	P08913_DB14185	n/a	DB14185	n/a	n/a	Aripiprazole lauroxil	n/a