Gene name: LTA4H
Protein name: Leukotriene A-4 hydrolase
List of molecules and drugs that interact with protein P09960
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P09960_00G | 00G | DB06828 | 44129621 | n/a | 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole | inhibitor | |
| 2 | P09960_11S | 11S | n/a | 87110 | CHEMBL555013 | 5-chloro-1H-indole | n/a | |
| 3 | P09960_11X | 11X | DB06851 | 1082702 | CHEMBL264669 | N-(pyridin-3-ylmethyl)aniline | inhibitor | IC50(nM) = 1321000.0 |
| 4 | P09960_14O | 14O | n/a | 67861 | CHEMBL555457 | 5-fluoro-1H-indole | n/a | |
| 5 | P09960_1V6 | 1V6 | n/a | 3768902 | CHEMBL3883608 | 4-(4-benzylphenyl)-1,3-thiazol-2-amine | n/a | |
| 6 | P09960_22F | 22F | DB06917 | 7023019 | CHEMBL563196 | (4-fluorophenyl)(pyridin-4-yl)methanone | inhibitor | IC50(nM) = 3673000.0 |
| 7 | P09960_24P | 24P | n/a | 16222640 | CHEMBL571091 | (2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine | n/a | |
| 8 | P09960_25P | 25P | n/a | 49866439 | n/a | 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate | n/a | |
| 9 | P09960_27P | 27P | n/a | 164472 | CHEMBL14608 | 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine | n/a | |
| 10 | P09960_28P | 28P | n/a | 9820434;71772315; | CHEMBL112671 | N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine | n/a | |
| 11 | P09960_28T | 28T | n/a | 73167569 | n/a | 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline | n/a | |
| 12 | P09960_3IP | 3IP | DB02352 | 90334 | CHEMBL194009 | 3-(BENZYLOXY)PYRIDIN-2-AMINE | inhibitor | IC50(nM) = 308000.0 |
| 13 | P09960_492 | 492 | DB07094 | 2776424 | CHEMBL538940 | 1-(2,2'-bithiophen-5-yl)methanamine | inhibitor | IC50(nM) = 38900.0 |
| 14 | P09960_4BG | 4BG | DB07099 | 22690393 | CHEMBL479960 | N-[4-(benzyloxy)phenyl]glycinamide | inhibitor | IC50(nM) = 135.0 |
| 15 | P09960_4BO | 4BO | n/a | 24768559;44629677; | CHEMBL477307 | (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid | n/a | |
| 16 | P09960_4BQ | 4BQ | DB07102 | 24768560;44629678; | CHEMBL478381 | (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid | inhibitor | IC50(nM) = 20.0 |
| 17 | P09960_4BS | 4BS | DB07104 | 22692237 | CHEMBL478718 | 4-amino-N-[4-(benzyloxy)phenyl]butanamide | inhibitor | IC50(nM) = 61.0 |
| 18 | P09960_4BU | 4BU | n/a | 24768561;44629679; | n/a | (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid | n/a | |
| 19 | P09960_52D | 52D | n/a | 44221318 | CHEMBL565599 | pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone | n/a | |
| 20 | P09960_58Z | 58Z | n/a | 44129622;72199878; | CHEMBL562164 | 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid | n/a | |
| 21 | P09960_5H1 | 5H1 | n/a | 16054 | CHEMBL404923 | 1H-indol-5-ol | n/a | |
| 22 | P09960_692 | 692 | DB07196 | 7060565 | CHEMBL549343 | N-methyl-1-(2-thiophen-2-ylphenyl)methanamine | inhibitor | IC50(nM) = 1077000.0 |
| 23 | P09960_798 | 798 | DB07237 | 44129624 | CHEMBL561639 | {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone | n/a | IC50(nM) = 81.0 |
| 24 | P09960_80A | 80A | DB07258 | 44129623 | n/a | (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol | n/a | |
| 25 | P09960_80G | 80G | DB07259 | 2776332 | CHEMBL539640 | 1-(4-thiophen-2-ylphenyl)methanamine | inhibitor | IC50(nM) = 98000.0 |
| 26 | P09960_812 | 812 | DB07260 | 44129620 | CHEMBL570775 | N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline | inhibitor | IC50(nM) = 157.0 |
| 27 | P09960_848 | 848 | n/a | 8027171 | CHEMBL566838 | 2-(pyridin-3-ylmethoxy)aniline | n/a | |
| 28 | P09960_8KW | 8KW | n/a | 181271 | CHEMBL228126 | 3-[2-(2-hydroxyphenyl)ethyl]-5-methoxy-phenol | n/a | |
| 29 | P09960_92G | 92G | DB07292 | 346926 | CHEMBL483790 | 4-(2-amino-1,3-thiazol-4-yl)phenol | inhibitor | IC50(nM) = 1000000.0 |
| 30 | P09960_A4Z | A4Z | DB13346 | 2466 | CHEMBL94394 | 2-(4-butoxyphenyl)-N-hydroxyacetamide | n/a | |
| 31 | P09960_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | inhibitor | |
| 32 | P09960_ACY | ACY | DB03166 | 176;21980959;160748163; | CHEMBL539 | ACETIC ACID | n/a | |
| 33 | P09960_B3N | B3N | DB02565 | 3994 | CHEMBL140000 | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | n/a | |
| 34 | P09960_BES | BES | DB03424 | 72172;6992132; | CHEMBL29292 | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID | inhibitor | |
| 35 | P09960_BGK | BGK | n/a | 57448384 | n/a | 4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)benzaldehyde | n/a | |
| 36 | P09960_BGW | BGW | n/a | 11245596 | CHEMBL481280 | 1-[[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl]piperidine-4-carboxylic acid | n/a | |
| 37 | P09960_BIR | BIR | DB02062 | 5478838;58263406; | n/a | N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE | n/a | |
| 38 | P09960_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 39 | P09960_DJ3 | DJ3 | n/a | 5280383 | CHEMBL69439 | 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid | n/a | |
| 40 | P09960_DP8 | DP8 | n/a | 87057595 | CHEMBL3921982 | N,N-dimethyl-2-(4-phenoxyphenoxy)ethanamine | n/a | |
| 41 | P09960_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 42 | P09960_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
| 43 | P09960_KEL | KEL | DB08040 | 123982 | CHEMBL85320 | N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanine | n/a | |
| 44 | P09960_LNJ | LNJ | n/a | 145704648 | CHEMBL4476527 | 4-{4-[(4-methoxyphenyl)methyl]phenyl}-1,3-thiazol-2-amine | n/a | |
| 45 | P09960_N0Y | N0Y | n/a | 13264 | CHEMBL1915868 | 1-benzyl-4-methoxybenzene | n/a | |
| 46 | P09960_OD6 | OD6 | n/a | 163349486 | n/a | 4-[4-(phenylmethyl)phenyl]-1,3-selenazol-2-amine | n/a | |
| 47 | P09960_OVO | OVO | n/a | 163348709 | n/a | 4-[4-(phenylmethyl)phenyl]-1,3-oxazol-2-amine | n/a | |
| 48 | P09960_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 49 | P09960_PH0 | PH0 | n/a | 5289194;58263407; | n/a | N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine | n/a | |
| 50 | P09960_RE2 | RE2 | DB08466 | 185914 | CHEMBL111234 | 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol | inhibitor | IC50(nM) = 145000.0 |
| 51 | P09960_RZB | RZB | n/a | 118191832 | CHEMBL4858542 | (3~{R})-3-azanyl-4-[5-[4-(4-chloranylphenoxy)phenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid | n/a | |
| 52 | P09960_RZE | RZE | n/a | 118166560 | CHEMBL4852381 | (3~{S})-3-azanyl-4-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid | n/a | |
| 53 | P09960_RZK | RZK | n/a | 83535370 | CHEMBL4875329 | 2-[5-(4-methoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamine | n/a | |
| 54 | P09960_RZN | RZN | n/a | 826195 | CHEMBL4850613 | (4-phenoxyphenyl)methanol | n/a | |
| 55 | P09960_SHH | SHH | DB02546 | 5311 | CHEMBL98 | OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE | n/a | IC50(nM) = 1670.0 |
| 56 | P09960_X8Z | X8Z | DB01197 | 44093;12851888; | CHEMBL1560 | L-CAPTOPRIL | inhibitor | Ki(nM) = 3700.0 IC50(nM) = 70.0 Kd(nM) = 6250.0 |
| 57 | P09960_YB | YB | n/a | 105055 | n/a | YTTERBIUM (III) ION | n/a | |
| 58 | P09960_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 59 | P09960_STL | STL | DB02709 | 445154 | CHEMBL165 | RESVERATROL | n/a | IC50(nM) = 32200.0 |
| 60 | P09960_DB03366 | n/a | DB03366 | n/a | n/a | Imidazole | n/a | |
| 61 | P09960_DB11781 | n/a | DB11781 | n/a | n/a | Tosedostat | n/a |