Gene name: folA
Protein name: Dihydrofolate reductase (DHFR)
List of molecules and drugs that interact with protein P0A017
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P0A017_06U | 06U | n/a | 56955942 | CHEMBL4483572 | 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | n/a | |
| 2 | P0A017_06W | 06W | n/a | 56684135 | CHEMBL5284400 | 6-ethyl-5-{(3S)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | n/a | |
| 3 | P0A017_0U5 | 0U5 | n/a | 137347893 | n/a | (2E)-3-{5-[(2,4-diamino-6-propylpyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(2-methylprop-1-en-1-yl)phthalazin-2(1H)-yl]prop-2-en-1-one | n/a | |
| 4 | P0A017_0U6 | 0U6 | n/a | 137347894 | n/a | (2E)-3-{5-[(2,4-diamino-6-ethylpyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(2-methylprop-1-en-1-yl)phthalazin-2(1H)-yl]prop-2-en-1-one | n/a | |
| 5 | P0A017_1DN | 1DN | n/a | 56595785 | CHEMBL3128016 | 7-[5,6-dimethoxy-2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]quinazoline-2,4-diamine | n/a | |
| 6 | P0A017_1VM | 1VM | n/a | 46871716 | CHEMBL3128021 | 7-[5,6-dimethyl-2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]quinazoline-2,4-diamine | n/a | |
| 7 | P0A017_1VN | 1VN | n/a | 46898103 | CHEMBL3128014 | 6-chloro-7-[5,6-dimethyl-2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]quinazoline-2,4-diamine | n/a | |
| 8 | P0A017_1VO | 1VO | n/a | 72771095 | CHEMBL3128022 | 7-[5,6-dimethyl-2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]quinazoline-2,4-diamine | n/a | |
| 9 | P0A017_52V | 52V | n/a | 44223989 | CHEMBL576976 | 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | n/a | |
| 10 | P0A017_5DR | 5DR | n/a | 52949513 | CHEMBL1270533 | 6-ethyl-5-[3-(4-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine | n/a | |
| 11 | P0A017_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 12 | P0A017_DHF | DHF | DB02015 | 98792;5280349;135398604; | CHEMBL46294 | DIHYDROFOLIC ACID | n/a | |
| 13 | P0A017_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 14 | P0A017_G8J | G8J | n/a | 133107903 | n/a | 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | n/a | |
| 15 | P0A017_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 16 | P0A017_I2H | I2H | DB07938 | 44141864 | CHEMBL1673303 | 5-{[(2S)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl}pyrimidine-2,4-diamine | n/a | |
| 17 | P0A017_M23 | M23 | n/a | 53346509 | CHEMBL1818124 | 7-(5-bromo-2-ethoxyphenyl)-6-methylquinazoline-2,4-diamine | n/a | |
| 18 | P0A017_MMV | MMV | n/a | 66563688 | CHEMBL3040038 | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid | n/a | |
| 19 | P0A017_MTX | MTX | DB00563 | 126941 | CHEMBL34259 | METHOTREXATE | n/a | Ki(nM) = 1.0 IC50(nM) = 190.0 |
| 20 | P0A017_N22 | N22 | DB08234 | 25058133 | CHEMBL485961 | 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine | n/a | |
| 21 | P0A017_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 22 | P0A017_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 23 | P0A017_NDW | NDW | n/a | 12313073 | n/a | alpha-NADPH | n/a | |
| 24 | P0A017_O71 | O71 | n/a | 139267762 | n/a | (4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}phenyl)acetic acid | n/a | |
| 25 | P0A017_OWG | OWG | n/a | 146170547 | n/a | 3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-6,7-dimethoxy-1-(4-methoxyphenyl)-3,4-dihydrophthalazin-2(1H)-yl]propan-1-one | n/a | |
| 26 | P0A017_OWJ | OWJ | n/a | 146672960 | n/a | (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(3,5-dimethylphenyl)phthalazin-2(1H)-yl]prop-2-en-1-one | n/a | |
| 27 | P0A017_OWM | OWM | n/a | 146170546 | n/a | (2E)-1-[(1R)-1-cyclopropyl-6,7-dimethoxyphthalazin-2(1H)-yl]-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}prop-2-en-1-one | n/a | |
| 28 | P0A017_OWP | OWP | n/a | 146170542 | n/a | (2E)-1-[(1S)-1-benzylphthalazin-2(1H)-yl]-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}prop-2-en-1-one | n/a | |
| 29 | P0A017_OWS | OWS | n/a | 146170541 | n/a | (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(4-methylphenyl)phthalazin-2(1H)-yl]prop-2-en-1-one | n/a | |
| 30 | P0A017_OWV | OWV | n/a | 146672961 | n/a | (2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(pentan-3-yl)-3,4-dihydrophthalazin-2(1H)-yl]prop-2-en-1-one | n/a | |
| 31 | P0A017_Q11 | Q11 | n/a | 53346505 | CHEMBL1818113 | 7-(2-methoxyphenyl)quinazoline-2,4-diamine | n/a | |
| 32 | P0A017_Q12 | Q12 | n/a | 53346506 | CHEMBL1818114 | 7-(3,4-dimethoxyphenyl)-6-methylquinazoline-2,4-diamine | n/a | |
| 33 | P0A017_Q19 | Q19 | n/a | 53346507 | CHEMBL1818120 | 1-[3-(2,4-diamino-6-methylquinazolin-7-yl)phenyl]ethanone | n/a | |
| 34 | P0A017_Q20 | Q20 | n/a | 53346508 | CHEMBL1818121 | 3-(2,4-diamino-6-methylquinazolin-7-yl)-4-ethoxybenzaldehyde | n/a | |
| 35 | P0A017_Q26 | Q26 | n/a | 53346510 | CHEMBL1818127 | N-[3'-(2,4-diaminoquinazolin-7-yl)-4'-ethoxybiphenyl-3-yl]methanesulfonamide | n/a | |
| 36 | P0A017_Q27 | Q27 | n/a | 53346511 | CHEMBL1818128 | 7-(2-ethoxynaphthalen-1-yl)-6-methylquinazoline-2,4-diamine | n/a | |
| 37 | P0A017_R0Y | R0Y | n/a | 146170545 | n/a | (2E)-1-[(1S)-1-cyclopropyl-6,7-dimethoxy-3,4-dihydrophthalazin-2(1H)-yl]-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}prop-2-en-1-one | n/a | |
| 38 | P0A017_RAR | RAR | n/a | 42627761 | CHEMBL1235617 | 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine | n/a | |
| 39 | P0A017_TOP | TOP | DB00440 | 5578 | CHEMBL22 | TRIMETHOPRIM | n/a | Ki(nM) = 1.2 IC50(nM) = 7.0 |
| 40 | P0A017_U06 | U06 | n/a | 121493974 | CHEMBL3827532 | 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid | n/a | |
| 41 | P0A017_U75 | U75 | n/a | 123133740 | CHEMBL3828771 | 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid | n/a | |
| 42 | P0A017_UC9 | UC9 | n/a | 124081253 | n/a | 4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}benzoic acid | n/a | |
| 43 | P0A017_XCF | XCF | DB08741 | 10247560 | CHEMBL1236788 | 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine | n/a | IC50(nM) = 2.9 |
| 44 | P0A017_XNP | XNP | n/a | 137350166 | n/a | Tricyclic NADPH | n/a |