Gene name: gyrB
Protein name: DNA gyrase subunit
List of molecules and drugs that interact with protein P0A0K8
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P0A0K8_07N | 07N | n/a | 11718729 | CHEMBL1923440 | 2-[(3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-fluoropiperidin-1-yl]-1,3-thiazole-5-carboxylic acid | n/a | |
| 2 | P0A0K8_087 | 087 | n/a | 11212591 | CHEMBL1923431 | 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)pyridine-4-carboxamide | n/a | |
| 3 | P0A0K8_08B | 08B | n/a | 54759160 | n/a | 4-bromo-5-methyl-N-[1-(3-nitropyridin-2-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide | n/a | |
| 4 | P0A0K8_31N | 31N | n/a | n/a | n/a | 6-[({(1r,4S)-1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]oct-4-yl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one | n/a | |
| 5 | P0A0K8_54X | 54X | n/a | 665387 | CHEMBL559696 | 5-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4(1H)-one | n/a | |
| 6 | P0A0K8_55D | 55D | n/a | 2970903 | CHEMBL3759276 | 2-(butanoylamino)thiophene-3-carboxamide | n/a | |
| 7 | P0A0K8_55G | 55G | n/a | 117072442;135567070; | CHEMBL3759862 | 4-phenyl-3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | n/a | |
| 8 | P0A0K8_55H | 55H | n/a | 117072443;135567071; | CHEMBL3759063 | 3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | n/a | |
| 9 | P0A0K8_57U | 57U | n/a | 92045128 | CHEMBL3735431 | 1-ethyl-3-[4-(hydroxymethyl)-5-(1H-pyrrol-2-yl)-1,3-thiazol-2-yl]urea | n/a | |
| 10 | P0A0K8_57V | 57V | n/a | 92045129 | CHEMBL3736029 | 1-ethyl-3-{4-[(E)-2-(pyridin-3-yl)ethenyl]-5-(1H-pyrrol-2-yl)-1,3-thiazol-2-yl}urea | n/a | |
| 11 | P0A0K8_57W | 57W | n/a | 92045130 | CHEMBL3736222 | 1-ethyl-3-[1-(pyridin-2-yl)-6-(pyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl]urea | n/a | |
| 12 | P0A0K8_57X | 57X | n/a | 71721528 | CHEMBL3810359 | 7-propyl-3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | n/a | |
| 13 | P0A0K8_57Y | 57Y | n/a | 135567073 | CHEMBL3739628 | 3-hydroxy-5-[5-(6-hydroxy-7-propyl-2H-indazol-3-yl)-1,3-thiazol-2-yl]pyridine-2-carboxylic acid | n/a | |
| 14 | P0A0K8_AX7 | AX7 | n/a | 13624 | CHEMBL305513 | 1H-benzimidazol-2-amine | n/a | |
| 15 | P0A0K8_B47 | B47 | n/a | 44608008 | CHEMBL1094382 | methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate | n/a | |
| 16 | P0A0K8_B48 | B48 | n/a | 2744426 | CHEMBL1098685 | 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole | n/a | |
| 17 | P0A0K8_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | P0A0K8_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 19 | P0A0K8_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 20 | P0A0K8_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 21 | P0A0K8_EVO | EVO | n/a | 16039283 | CHEMBL3760057 | (3E)-3-(pyridin-3-ylmethylidene)-1,3-dihydro-2H-indol-2-one | n/a | |
| 22 | P0A0K8_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 23 | P0A0K8_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
| 24 | P0A0K8_JK8 | JK8 | n/a | 137796790 | CHEMBL4445556 | (2~{R})-2-[[5-(2-chlorophenyl)-1,2-benzoxazol-3-yl]oxy]-2-phenyl-ethanamine | n/a | |
| 25 | P0A0K8_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 26 | P0A0K8_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 27 | P0A0K8_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 28 | P0A0K8_N1N | N1N | n/a | 151595514 | CHEMBL4854181 | 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-phenylmethoxy-1,3-benzothiazole-6-carboxylic acid | n/a | |
| 29 | P0A0K8_NOV | NOV | DB01051 | 54675769 | CHEMBL36506 | NOVOBIOCIN | inhibitor | IC50(nM) = 30.0 |
| 30 | P0A0K8_NWK | NWK | n/a | 153541355 | CHEMBL5028560 | 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-(2-morpholin-4-ylethoxy)-1,3-benzothiazole-6-carboxylic acid | n/a | |
| 31 | P0A0K8_Q52 | Q52 | n/a | 154685085 | CHEMBL4861727 | ~{N}-[(4-chlorophenyl)methyl]-1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-4-amine | n/a | |
| 32 | P0A0K8_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 33 | P0A0K8_WCP | WCP | n/a | n/a | n/a | (4R)-3-fluoro-4-hydroxy-4-{[(1r,4R)-4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}-2-oxabicyclo[2.2.2]oct-1-yl]methyl}-4,5-dihydro-7H-pyrrolo[3,2,1-de][1,5]naphthyridin-7-one | n/a | |
| 34 | P0A0K8_XAM | XAM | n/a | n/a | n/a | (1R,4aS,5S,6S,8aR)-5-{[(5S)-1-(3-O-acetyl-4-O-carbamoyl-6-deoxy-2-O-methyl-alpha-L-talopyranosyl)-4-hydroxy-2-oxo-5-(propan-2-yl)-2,5-dihydro-1H-pyrrol-3-yl]carbonyl}-6-methyl-4-methylidene-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl 2,6-dideoxy-3-C-[(1S)-1-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}ethyl]-beta-D-ribo-hexopyranoside | n/a | |
| 35 | P0A0K8_Y1W | Y1W | n/a | n/a | n/a | (1S)-2-[(2r,5S)-5-{[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]amino}-1,3-dioxan-2-yl]-1-(3-fluoro-6-methoxyquinolin-4-yl)ethan-1-ol | n/a |