Gene name: folA
Protein name: Dihydrofolate reductase (EC
List of molecules and drugs that interact with protein P0ABQ4
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P0ABQ4_2MX | 2MX | n/a | 49786966 | n/a | (2S,2'S)-5,5'-(nonane-1,9-diyldiimino)bis(2-{[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)carbonyl]amino}-5-oxopentanoic acid) (non-preferred name) | n/a | |
| 2 | P0ABQ4_6ME | 6ME | n/a | 137348488 | n/a | (6S)-6-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine | n/a | |
| 3 | P0ABQ4_7ME | 7ME | n/a | 54765326 | n/a | (7S)-7-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine | n/a | |
| 4 | P0ABQ4_817 | 817 | DB07262 | 9543472 | CHEMBL387262 | 1-{[N-(1-IMINO-GUANIDINO-METHYL)]SULFANYLMETHYL}-3-TRIFLUOROMETHYL-BENZENE | n/a | IC50(nM) = 4300.0 |
| 5 | P0ABQ4_8CV | 8CV | DB00914 | 8249 | CHEMBL170988 | N-(2-phenylethyl)imidodicarbonimidic diamide | n/a | |
| 6 | P0ABQ4_8DM | 8DM | n/a | 196473 | CHEMBL3278332 | N-(4-aminobenzene-1-carbonyl)-L-glutamic acid | n/a | |
| 7 | P0ABQ4_ATR | ATR | DB02363 | 165230 | n/a | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE | n/a | |
| 8 | P0ABQ4_BFR | BFR | DB04830 | 2468 | CHEMBL39736 | N-butyl-N'-(diaminomethylidene)guanidine | n/a | |
| 9 | P0ABQ4_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 10 | P0ABQ4_C1A | C1A | n/a | 9543473 | CHEMBL213969 | (2,5-dimethylbenzene-1,4-diyl)dimethanediyl bis(N-carbamimidoylcarbamimidothioate) | n/a | |
| 11 | P0ABQ4_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 12 | P0ABQ4_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 13 | P0ABQ4_D4C | D4C | n/a | 85934126 | CHEMBL5194771 | 7-[(2-fluorophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine | n/a | |
| 14 | P0ABQ4_DDF | DDF | DB12769 | 148138;5288038;135413518; | CHEMBL34412 | 5,10-DIDEAZATETRAHYDROFOLIC ACID | n/a | |
| 15 | P0ABQ4_DHF | DHF | DB02015 | 98792;5280349;135398604; | CHEMBL46294 | DIHYDROFOLIC ACID | n/a | |
| 16 | P0ABQ4_DZF | DZF | n/a | 445175;135460994; | n/a | 5-DEAZAFOLIC ACID | n/a | |
| 17 | P0ABQ4_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 18 | P0ABQ4_EOH | EOH | DB00898 | 702 | CHEMBL545 | ETHANOL | n/a | |
| 19 | P0ABQ4_FFO | FFO | DB11596 | 149436;135398559; | CHEMBL1908841 | N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid | n/a | |
| 20 | P0ABQ4_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 21 | P0ABQ4_FOL | FOL | DB00158 | 6037;5280354;135398658; | CHEMBL1622 | FOLIC ACID | n/a | |
| 22 | P0ABQ4_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 23 | P0ABQ4_JZM | JZM | n/a | 462589 | CHEMBL310759 | 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine | n/a | |
| 24 | P0ABQ4_LG3 | LG3 | n/a | 67431 | CHEMBL1233987 | PYRIMIDINE-2,4-DIAMINE | n/a | |
| 25 | P0ABQ4_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 26 | P0ABQ4_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 27 | P0ABQ4_MT1 | MT1 | n/a | 444319;69085264; | n/a | N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID | n/a | |
| 28 | P0ABQ4_MTX | MTX | DB00563 | 126941 | CHEMBL34259 | METHOTREXATE | n/a | IC50(nM) = 3.0 EC50(nM) = 1.0 |
| 29 | P0ABQ4_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 30 | P0ABQ4_NAP | NAP | DB03461 | 5885;57525501; | CHEMBL295069 | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 31 | P0ABQ4_NDP | NDP | DB02338 | 5884;134821689; | CHEMBL407009 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | n/a | |
| 32 | P0ABQ4_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 33 | P0ABQ4_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 34 | P0ABQ4_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 35 | P0ABQ4_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 36 | P0ABQ4_PQD | PQD | n/a | 22767698 | n/a | 7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | n/a | |
| 37 | P0ABQ4_Q24 | Q24 | n/a | 65087 | CHEMBL268354 | quinazoline-2,4-diamine | n/a | |
| 38 | P0ABQ4_R6F | R6F | DB16620 | 92929;135434845; | CHEMBL158990 | methopterin | n/a | |
| 39 | P0ABQ4_THG | THG | DB02031 | 5289465;5460413;135398650; | n/a | (6S)-5,6,7,8-TETRAHYDROFOLATE | n/a | |
| 40 | P0ABQ4_TOP | TOP | DB00440 | 5578 | CHEMBL22 | TRIMETHOPRIM | inhibitor | Ki(nM) = 3.0 IC50(nM) = 7.0 |
| 41 | P0ABQ4_URE | URE | DB03904 | 1176 | CHEMBL985 | UREA | n/a | |
| 42 | P0ABQ4_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a |