Gene name:
Protein name: Replicase polyprotein 1a
List of molecules and drugs that interact with protein P0C6U8
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P0C6U8_0EN | 0EN | n/a | 46897844 | CHEMBL2311740 | N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide | n/a | |
| 2 | P0C6U8_23H | 23H | n/a | 25681649 | n/a | N-[4-(acetylamino)phenyl]-2-(1H-benzotriazol-1-yl)-N-[(1R)-2-[(2-methylbutan-2-yl)amino]-1-(1-methyl-1H-pyrrol-2-yl)-2-oxoethyl]acetamide | n/a | |
| 3 | P0C6U8_3WL | 3WL | DB16101 | 5281605 | CHEMBL8260 | 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one | n/a | |
| 4 | P0C6U8_4IO | 4IO | n/a | 44580738 | CHEMBL496316 | 5-chloropyridin-3-yl 1-(3-nitrobenzene-1-sulfonyl)-1H-indole-5-carboxylate | n/a | |
| 5 | P0C6U8_4WI | 4WI | n/a | n/a | n/a | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide | n/a | |
| 6 | P0C6U8_7YY | 7YY | DB18834 | 162533924 | CHEMBL5183847 | 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | n/a | |
| 7 | P0C6U8_80I | 80I | DB16514 | 154699467 | CHEMBL4802214 | [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | n/a | |
| 8 | P0C6U8_B1S | B1S | n/a | 137348969 | n/a | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | n/a | |
| 9 | P0C6U8_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 10 | P0C6U8_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 11 | P0C6U8_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 12 | P0C6U8_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 13 | P0C6U8_EOC | EOC | n/a | 134131203 | CHEMBL3885329 | (2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide | n/a | |
| 14 | P0C6U8_EOF | EOF | n/a | 146672919 | CHEMBL5195478 | (2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide | n/a | |
| 15 | P0C6U8_FNO | FNO | n/a | 479503 | CHEMBL9470 | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione | n/a | |
| 16 | P0C6U8_G75 | G75 | n/a | 137349402 | n/a | ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE | n/a | |
| 17 | P0C6U8_G81 | G81 | n/a | 137349405 | n/a | ETHYL (4R)-4-{[N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANYL]AMINO}-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE | n/a | |
| 18 | P0C6U8_G82 | G82 | n/a | 137349406 | n/a | ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | n/a | |
| 19 | P0C6U8_G83 | G83 | n/a | 137349407 | n/a | ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | n/a | |
| 20 | P0C6U8_G85 | G85 | n/a | 137349409 | n/a | N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide | n/a | |
| 21 | P0C6U8_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 22 | P0C6U8_GRM | GRM | n/a | 46174170 | CHEMBL1173044 | N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide | n/a | |
| 23 | P0C6U8_HUR | HUR | n/a | 72708377 | CHEMBL2435614 | N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | n/a | |
| 24 | P0C6U8_J7R | J7R | n/a | 156774920 | CHEMBL5404334 | ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide | n/a | |
| 25 | P0C6U8_K36 | K36 | n/a | 118737648 | CHEMBL3559293 | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | n/a | |
| 26 | P0C6U8_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 27 | P0C6U8_MPD | MPD | DB03564 | 5288834 | n/a | (4S)-2-METHYL-2,4-PENTANEDIOL | n/a | |
| 28 | P0C6U8_MRD | MRD | n/a | 5288845 | n/a | (4R)-2-METHYLPENTANE-2,4-DIOL | n/a | |
| 29 | P0C6U8_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 30 | P0C6U8_NH4 | NH4 | n/a | 223;16741146; | n/a | AMMONIUM ION | n/a | |
| 31 | P0C6U8_NHE | NHE | DB03309 | 66898;3852474; | n/a | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | n/a | |
| 32 | P0C6U8_OEW | OEW | n/a | 146018711 | n/a | ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclohexyl-1-[[(2~{S},3~{R})-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate | n/a | |
| 33 | P0C6U8_P85 | P85 | n/a | 73659185 | CHEMBL3233814 | N-[(4-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide | n/a | |
| 34 | P0C6U8_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 35 | P0C6U8_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 36 | P0C6U8_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 37 | P0C6U8_QYS | QYS | n/a | 166625508 | CHEMBL5095608 | (1S,2S)-2-[(N-{[(4,4-difluorocyclohexyl)methoxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | n/a | |
| 38 | P0C6U8_S88 | S88 | n/a | 73659186 | CHEMBL3233815 | N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide | n/a | |
| 39 | P0C6U8_S89 | S89 | n/a | 137349985 | n/a | N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-Nalpha-[(2E)-3-phenylprop-2-enoyl]-L-phenylalaninamide | n/a | |
| 40 | P0C6U8_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 41 | P0C6U8_TTT | TTT | DB08656 | 24941262 | CHEMBL549695 | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide | n/a | IC50(nM) = 600.0 |
| 42 | P0C6U8_V2M | V2M | n/a | 154699443 | n/a | N-[(2S)-1-({(2S,3S)-3,4-dihydroxy-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | n/a | |
| 43 | P0C6U8_V34 | V34 | n/a | 146681157 | n/a | ethyl (2E,4S)-4-{[N-(4-methoxy-1H-indole-2-carbonyl)-L-leucyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate | n/a | |
| 44 | P0C6U8_V3D | V3D | n/a | 146681158 | CHEMBL4763730 | (3S)-3-{[N-(4-methoxy-1H-indole-2-carbonyl)-L-leucyl]amino}-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl 2-cyanobenzoate | n/a | |
| 45 | P0C6U8_VDJ | VDJ | n/a | 154572003 | n/a | [4,4-bis(fluoranyl)cyclohexyl]methyl ~{N}-[(2~{S})-1-[[(1~{R},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate | n/a | |
| 46 | P0C6U8_VR4 | VR4 | n/a | 155804578 | n/a | N-{(2S,3R)-4-(benzylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-N~2~-[(benzyloxy)carbonyl]-L-leucinamide | n/a | |
| 47 | P0C6U8_XNV | XNV | n/a | 137350167 | n/a | ethyl (4R)-4-({(2S)-2-[3-{[(5-methyl-1,2-oxazol-3-yl)carbonyl]amino}-2-oxopyridin-1(2H)-yl]pent-4-ynoyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate | n/a | |
| 48 | P0C6U8_Y67 | Y67 | n/a | 156026028 | CHEMBL5081793 | 2-(benzotriazol-1-yl)-~{N}-[(3-chlorophenyl)methyl]-~{N}-[4-(2-oxidanylidene-1~{H}-pyridin-3-yl)phenyl]ethanamide | n/a | |
| 49 | P0C6U8_Y6A | Y6A | n/a | 156026026 | CHEMBL5092270 | 2-(benzotriazol-1-yl)-~{N}-[4-(1~{H}-pyrazol-4-yl)phenyl]-~{N}-(thiophen-3-ylmethyl)ethanamide | n/a | |
| 50 | P0C6U8_Y6D | Y6D | n/a | 56973495 | CHEMBL2442056 | 2-(benzotriazol-1-yl)-~{N}-(4-pyridin-3-ylphenyl)-~{N}-(thiophen-3-ylmethyl)ethanamide | n/a | |
| 51 | P0C6U8_Y6G | Y6G | n/a | 156026027 | CHEMBL5092107 | 2-(benzotriazol-1-yl)-~{N}-[4-(1~{H}-imidazol-4-yl)phenyl]-~{N}-(thiophen-3-ylmethyl)ethanamide | n/a | |
| 52 | P0C6U8_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 53 | P0C6U8_ZU3 | ZU3 | n/a | 49867916 | n/a | N-[(benzyloxy)carbonyl]-3-[(2,2-dimethylpropanoyl)amino]-L-alanyl-N-[(1R)-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}pentyl]-L-leucinamide | n/a | |
| 54 | P0C6U8_ZU5 | ZU5 | n/a | 49867917 | n/a | N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-[(1R)-4-cyclopropyl-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}butyl]-L-leucinamide | n/a |