Gene name: BCL2
Protein name: Apoptosis regulator Bcl-2
List of molecules and drugs that interact with protein P10415
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P10415_1E9 | 1E9 | n/a | 71527841 | CHEMBL2322027 | N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide | n/a | |
| 2 | P10415_1XJ | 1XJ | DB12340 | 24978538 | CHEMBL443684 | 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide | inhibitor | |
| 3 | P10415_1XV | 1XV | n/a | 71656178 | CHEMBL3794524 | 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide | n/a | |
| 4 | P10415_1Y1 | 1Y1 | n/a | 71656179 | CHEMBL3794549 | 4-[4-({4'-chloro-3-[2-(dimethylamino)ethoxy]biphenyl-2-yl}methyl)piperazin-1-yl]-2-(1H-indol-5-yloxy)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)benzamide | n/a | |
| 5 | P10415_2PE | 2PE | n/a | 4867 | n/a | NONAETHYLENE GLYCOL | n/a | |
| 6 | P10415_398 | 398 | n/a | 56973535 | CHEMBL2031018 | N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide | n/a | |
| 7 | P10415_43B | 43B | n/a | 4369510 | CHEMBL1230221 | 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | n/a | |
| 8 | P10415_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 9 | P10415_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 10 | P10415_DRO | DRO | n/a | 25113117 | CHEMBL503454 | 1-(2-{[(3S)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide | n/a | |
| 11 | P10415_F3Q | F3Q | DB18365 | 71654876 | CHEMBL3958369 | ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide | n/a | |
| 12 | P10415_IQ8 | IQ8 | n/a | 168654843 | n/a | N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide | n/a | |
| 13 | P10415_J1H | J1H | n/a | 138393393 | CHEMBL4453237 | [(3~{R})-3-[[4-[[4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]phenyl]carbonylsulfamoyl]-2-nitro-phenyl]amino]-4-phenylsulfanyl-butyl]-(2-hydroxy-2-oxoethyl)-dimethyl-azanium | n/a | |
| 14 | P10415_J1Q | J1Q | n/a | 138393395 | CHEMBL4438456 | 1-[2-[[(3~{S})-3-(aminomethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]phenyl]-~{N},~{N}-dibutyl-5-methyl-pyrazole-3-carboxamide | n/a | |
| 15 | P10415_J1T | J1T | n/a | 138393394 | n/a | 4-[4-[(1~{R})-1-(6-methoxy-1,3-benzodioxol-5-yl)-2-pyrrolidin-1-yl-ethyl]phenyl]-~{N}-[4-[[(2~{R})-4-morpholin-4-yl-1-phenylsulfanyl-butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonyl-benzamide | n/a | |
| 16 | P10415_JFF | JFF | n/a | n/a | n/a | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid | n/a | |
| 17 | P10415_LBM | LBM | DB11581 | 49846579 | CHEMBL3137309 | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide | antagonist | |
| 18 | P10415_LI0 | LI0 | n/a | 15991563 | CHEMBL218222 | 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE | n/a | |
| 19 | P10415_LIU | LIU | n/a | 15991562 | CHEMBL387141 | N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide | n/a | |
| 20 | P10415_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 21 | P10415_ULL | ULL | n/a | 168477830 | n/a | propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate | n/a | |
| 22 | P10415_XZD | XZD | n/a | 54755012 | CHEMBL3970353 | Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester | n/a | |
| 23 | P10415_DB01050 | n/a | DB01050 | n/a | n/a | Ibuprofen | modulator | |
| 24 | P10415_TA1 | TA1 | DB01229 | 36314 | CHEMBL428647 | Paclitaxel | inhibitor | |
| 25 | P10415_TXL | TXL | DB01248 | 148124 | CHEMBL92 | Docetaxel | n/a | |
| 26 | P10415_RAU | RAU | DB01367 | 3052776 | CHEMBL887 | Rasagiline | activator | |
| 27 | P10415_DB05103 | n/a | DB05103 | n/a | n/a | AN-9 | downregulator | |
| 28 | P10415_DB05297 | n/a | DB05297 | n/a | n/a | Paclitaxel docosahexaenoic acid | n/a | |
| 29 | P10415_DB06307 | n/a | DB06307 | n/a | n/a | Apoptone | n/a | |
| 30 | P10415_6K9 | 6K9 | DB08871 | 11354606 | CHEMBL1683590 | Eribulin | n/a | |
| 31 | P10415_IBP | IBP | DB09213 | 39912 | CHEMBL175 | Dexibuprofen | negative modulator | |
| 32 | P10415_DB12191 | n/a | DB12191 | n/a | n/a | Obatoclax | inhibitor | |
| 33 | P10415_DB12816 | n/a | DB12816 | n/a | n/a | Terpinen-4-ol | regulator | |
| 34 | P10415_DB12843 | n/a | DB12843 | n/a | n/a | Oleandrin | downregulator |