Gene name: KIT
Protein name: Mast/stem cell growth
List of molecules and drugs that interact with protein P10721
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P10721_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | inhibitor | IC50(nM) = 1.7 |
| 2 | P10721_647 | 647 | n/a | 11545419 | CHEMBL4224714 | 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine | n/a | |
| 3 | P10721_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 4 | P10721_AWO | AWO | n/a | 140430622 | n/a | N-(5-ethyl-1,2-oxazol-3-yl)-N'-[4-(2-{[6-(4-ethylpyrazin-1(4H)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | n/a | |
| 5 | P10721_B49 | B49 | DB01268 | 5329102 | CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | inhibitor | Ki(nM) = 4.0 IC50(nM) = 0.8 Kd(nM) = 0.21 |
| 6 | P10721_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 7 | P10721_CO | CO | n/a | 104729 | n/a | COBALT (II) ION | n/a | |
| 8 | P10721_DJX | DJX | n/a | 137355932 | CHEMBL4596788 | N-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine | n/a | |
| 9 | P10721_F82 | F82 | n/a | 134814266 | CHEMBL4212563 | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide | n/a | |
| 10 | P10721_F88 | F88 | n/a | 134814267 | CHEMBL4213606 | ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | n/a | |
| 11 | P10721_F8B | F8B | n/a | 134814268 | CHEMBL4214769 | ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | n/a | |
| 12 | P10721_F8H | F8H | n/a | 134814269 | CHEMBL4216473 | ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | n/a | |
| 13 | P10721_G4E | G4E | n/a | 53476185 | n/a | ~{N}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{H}-1,2,4-triazol-3-amine | n/a | |
| 14 | P10721_JWY | JWY | n/a | 24811925 | n/a | N-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-N'-phenylurea | n/a | |
| 15 | P10721_K3R | K3R | DB18087 | 155587867 | CHEMBL5314917 | ~{N}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | n/a | |
| 16 | P10721_KCI | KCI | n/a | 166625062 | n/a | 5-imidazo[1,2-a]pyridin-3-yl-~{N}-[(1~{R})-1-(6-pyrrolidin-1-ylpyridin-3-yl)ethyl]pyridin-3-amine | n/a | |
| 17 | P10721_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 18 | P10721_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 19 | P10721_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 20 | P10721_O2H | O2H | n/a | 146672939 | n/a | ~{N}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | n/a | |
| 21 | P10721_O2K | O2K | n/a | 146037622 | n/a | ~{N}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide | n/a | |
| 22 | P10721_O35 | O35 | n/a | 146037621 | n/a | ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | n/a | |
| 23 | P10721_P31 | P31 | DB12978 | 25151352 | CHEMBL3813873 | 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine | inhibitor | |
| 24 | P10721_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 25 | P10721_WEG | WEG | n/a | 155928410 | n/a | 2-phenyl-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | n/a | |
| 26 | P10721_WEJ | WEJ | DB18041 | 75593308 | CHEMBL5095229 | 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide | inhibitor | |
| 27 | P10721_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 28 | P10721_STI | STI | DB00619 | 5291 | CHEMBL941 | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | antagonist | Ki(nM) = 14.0 IC50(nM) = 16.0 Kd(nM) = 3.0 EC50(nM) = 100.0 |
| 29 | P10721_BAX | BAX | DB00398 | 216239 | CHEMBL1336 | Sorafenib | antagonist | Ki(nM) = 16000.0 IC50(nM) = 31.0 Kd(nM) = 16.0 |
| 30 | P10721_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | Dasatinib | antagonist | Ki(nM) = 620.0 IC50(nM) = 1.0 Kd(nM) = 0.4 |
| 31 | P10721_PTR | PTR | DB01962 | 30819 | CHEMBL286939 | Phosphonotyrosine | inhibitor | |
| 32 | P10721_NIL | NIL | DB04868 | 644241 | CHEMBL255863 | Nilotinib | antagonist | Ki(nM) = 2.0 IC50(nM) = 15.0 Kd(nM) = 17.0 |
| 33 | P10721_DB05913 | n/a | DB05913 | n/a | n/a | OSI-930 | modulator | |
| 34 | P10721_DB06080 | n/a | DB06080 | n/a | n/a | Linifanib | n/a | |
| 35 | P10721_DB06589 | n/a | DB06589 | n/a | n/a | Pazopanib | inhibitor | Ki(nM) = 2300.0 IC50(nM) = 118.0 Kd(nM) = 1.8 |
| 36 | P10721_2K2 | 2K2 | DB06595 | 9829523 | CHEMBL608533 | Midostaurin | antagonist | |
| 37 | P10721_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | IC50(nM) = 6.1 |
| 38 | P10721_LEV | LEV | DB09078 | 9823820 | CHEMBL1289601 | Lenvatinib | inhibitor | |
| 39 | P10721_AV9 | AV9 | DB11800 | 9911830 | CHEMBL1289494 | Tivozanib | inhibitor | |
| 40 | P10721_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 41 | P10721_5SF | 5SF | DB12147 | 67462786 | CHEMBL3545376 | Erdafitinib | substrate | |
| 42 | P10721_DB12742 | n/a | DB12742 | n/a | n/a | Amuvatinib | modulator | |
| 43 | P10721_DB14840 | n/a | DB14840 | n/a | n/a | Ripretinib | inhibitor | |
| 44 | P10721_DB15233 | n/a | DB15233 | n/a | n/a | Avapritinib | inhibitor |