Gene name: THRB
Protein name: Thyroid hormone receptor
List of molecules and drugs that interact with protein P10828
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P10828_442 | 442 | DB02106 | 5287509 | n/a | 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL | n/a | |
| 2 | P10828_4HY | 4HY | DB03604 | 5803 | CHEMBL41632 | [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID | agonist | IC50(nM) = 0.0407 |
| 3 | P10828_8HO | 8HO | DB04847 | 11256664 | CHEMBL2338329 | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid | n/a | |
| 4 | P10828_9GC | 9GC | n/a | 163321762 | CHEMBL5193673 | 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl)phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 5 | P10828_9IF | 9IF | n/a | 163321764 | CHEMBL5207720 | 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 6 | P10828_9II | 9II | n/a | 163321765 | CHEMBL5171808 | 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 7 | P10828_9IL | 9IL | n/a | 163321766 | CHEMBL5178553 | 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 8 | P10828_9IQ | 9IQ | n/a | 163321767 | CHEMBL5204264 | 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 9 | P10828_9IT | 9IT | n/a | 163321768 | CHEMBL5173831 | 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 10 | P10828_9IW | 9IW | n/a | 163321769 | CHEMBL5181604 | 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl)carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid | n/a | |
| 11 | P10828_ARS | ARS | n/a | 23969 | CHEMBL1231052 | ARSENIC | n/a | |
| 12 | P10828_B72 | B72 | DB07425 | 9862248 | CHEMBL107400 | {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid | n/a | Ki(nM) = 0.32 Kd(nM) = 0.067 EC50(nM) = 2.82 |
| 13 | P10828_CAC | CAC | n/a | 167250 | n/a | CACODYLATE ION | n/a | |
| 14 | P10828_G24 | G24 | DB03788 | 448011 | n/a | [4-(3-BENZYL-4-HYDROXYBENZYL)-3,5-DIMETHYLPHENOXY]ACETIC ACID | inhibitor | |
| 15 | P10828_IH5 | IH5 | DB03176 | 9863447 | CHEMBL41036 | {3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID | n/a | Ki(nM) = 0.24 IC50(nM) = 1.1 EC50(nM) = 0.78 |
| 16 | P10828_LEG | LEG | DB08085 | 14899645 | CHEMBL237600 | 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE | inhibitor | IC50(nM) = 1500.0 |
| 17 | P10828_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 18 | P10828_OEF | OEF | n/a | 10456830 | CHEMBL289343 | 3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID | n/a | |
| 19 | P10828_PFA | PFA | DB03181 | 447271 | CHEMBL125381 | [4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PHENYL]-6-AZAURACIL | n/a | Ki(nM) = 0.03 |
| 20 | P10828_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 21 | P10828_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 22 | P10828_T3 | T3 | DB00279 | 5920;7048703; | CHEMBL1544 | 3,5,3'TRIIODOTHYRONINE | agonist | Ki(nM) = 0.08 IC50(nM) = 0.257 Kd(nM) = 0.081 EC50(nM) = 1.1 |
| 23 | P10828_T44 | T44 | DB00451 | 5819;25201348; | CHEMBL1624 | 3,5,3',5'-TETRAIODO-L-THYRONINE | agonist | EC50(nM) = 240.0 |
| 24 | P10828_DB00509 | n/a | DB00509 | n/a | n/a | Dextrothyroxine | agonist | |
| 25 | P10828_DB01583 | n/a | DB01583 | n/a | n/a | Liotrix | agonist | |
| 26 | P10828_64L | 64L | DB05035 | 10299876 | CHEMBL2035874 | Eprotirome | n/a |