Gene name: TOP1
Protein name: DNA topoisomerase 1
List of molecules and drugs that interact with protein P11387
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P11387_AI3 | AI3 | DB07354 | 5287652 | n/a | 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM | n/a | |
| 2 | P11387_EHD | EHD | DB04690 | 24360 | CHEMBL65 | 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE | inhibitor | IC50(nM) = 25.0 EC50(nM) = 350.0 |
| 3 | P11387_HG | HG | n/a | 26623 | n/a | MERCURY (II) ION | n/a | |
| 4 | P11387_M38 | M38 | DB08159 | 5288720 | CHEMBL343336 | 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE | n/a | |
| 5 | P11387_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 6 | P11387_SA3 | SA3 | n/a | 657084 | n/a | 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE | n/a | |
| 7 | P11387_TTC | TTC | DB01030 | 60700 | CHEMBL84 | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE | inhibitor | IC50(nM) = 21.0 Kd(nM) = 26.5 EC50(nM) = 54.0 |
| 8 | P11387_TTG | TTG | n/a | 183113;29987516; | n/a | 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID | n/a | |
| 9 | P11387_CP0 | CP0 | DB00762 | 60838 | CHEMBL481 | Irinotecan | inhibitor | |
| 10 | P11387_DB00970 | n/a | DB00970 | n/a | n/a | Dactinomycin | inhibitor | |
| 11 | P11387_DM2 | DM2 | DB00997 | 31703 | CHEMBL53463 | Doxorubicin | inhibitor | IC50(nM) = 3200.0 |
| 12 | P11387_DB04882 | n/a | DB04882 | n/a | n/a | Edotecarin | inhibitor | |
| 13 | P11387_DB04967 | n/a | DB04967 | n/a | n/a | Lucanthone | inhibitor | |
| 14 | P11387_DB05129 | n/a | DB05129 | n/a | n/a | Elsamitrucin | n/a | |
| 15 | P11387_RS4 | RS4 | DB05482 | 104842 | CHEMBL837 | 7-ethyl-10-hydroxycamptothecin | inhibitor | IC50(nM) = 1000.0 |
| 16 | P11387_DB05630 | n/a | DB05630 | n/a | n/a | Sodium stibogluconate | inhibitor | |
| 17 | P11387_DB05806 | n/a | DB05806 | n/a | n/a | Cositecan | inhibitor | |
| 18 | P11387_DB06159 | n/a | DB06159 | n/a | n/a | Rubitecan | inhibitor | |
| 19 | P11387_DB11254 | n/a | DB11254 | n/a | n/a | Hexylresorcinol | inhibitor |