Gene name: VDR
Protein name: Vitamin D3 receptor
List of molecules and drugs that interact with protein P11473
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P11473_0CO | 0CO | n/a | 49866383 | CHEMBL1229568 | (1S,3R,5Z,7E,14beta,17alpha,23R)-23-(2-hydroxy-2-methylpropyl)-20,24-epoxy-9,10-secochola-5,7,10-triene-1,3-diol | n/a | |
| 2 | P11473_0VQ | 0VQ | n/a | 59263691 | CHEMBL2171447 | (3E,5E)-6-(3-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}phenyl)-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol | n/a | |
| 3 | P11473_23R | 23R | n/a | 44602355 | n/a | (1S,2S,3R,5Z,7E,14beta,17alpha,23R)-23-(2-hydroxy-2-methylpropyl)-2-methyl-20,24-epoxy-9,10-secochola-5,7,10-triene-1,3-diol | n/a | |
| 4 | P11473_2KB | 2KB | n/a | 91667408 | n/a | 4-{[(1R,2S,3R,5Z,7E,14beta,17alpha)-1,3,25-trihydroxy-9,10-secocholesta-5,7,10-trien-2-yl]oxy}butanenitrile | n/a | |
| 5 | P11473_2MV | 2MV | n/a | 44602354 | n/a | (1S,2S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-2-methyl-9,10-secoandrosta-5,7,10-triene-1,3-diol | n/a | |
| 6 | P11473_3AJ | 3AJ | n/a | 86306041 | n/a | 1-({[(1R,2S,3R,5Z,7E,14beta,17alpha)-1,3,25-trihydroxy-9,10-secocholesta-5,7,10-trien-2-yl]oxy}methyl)cyclopropanecarbonitrile | n/a | |
| 7 | P11473_3EV | 3EV | n/a | 5283736 | n/a | (1S,3S,5Z,7E,14beta,17alpha)-9,10-secocholesta-5,7,10-triene-1,3,25-triol | n/a | |
| 8 | P11473_41V | 41V | n/a | 102430413 | n/a | (1R,3R,7Z,14beta,17alpha)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-9,10-secoestra-5,7-diene-1,3-diol | n/a | |
| 9 | P11473_41W | 41W | n/a | 112499878 | n/a | (1R,3R)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol | n/a | |
| 10 | P11473_6DS | 6DS | n/a | 11577808 | CHEMBL2348360 | (4S)-4-hydroxy-5-[2-methyl-4-(3-{3-methyl-4-[(1E)-4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)but-1-en-1-yl]phenyl}pentan-3-yl)phenoxy]pentanoic acid | n/a | |
| 11 | P11473_8VM | 8VM | n/a | 132471742 | n/a | 5-(3-{4-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-3-methylphenyl}pentan-3-yl)-3-methyl-N-(1H-tetrazol-5-yl)thiophene-2-carboxamide | n/a | |
| 12 | P11473_90L | 90L | n/a | 132990866 | n/a | (1R,2R,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]e thenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol | n/a | |
| 13 | P11473_90O | 90O | n/a | 132990867 | n/a | (1R,2S,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol | n/a | |
| 14 | P11473_C33 | C33 | n/a | 10062705 | CHEMBL378356 | 2ALPHA-PROPYL-1ALPHA,25-DIHYDROXYVITAMIN D3 | n/a | |
| 15 | P11473_C3O | C3O | n/a | 10062706 | n/a | 2ALPHA-PROPOXY-1ALPHA,25-DIHYDROXYVITAMIN D3 | n/a | |
| 16 | P11473_CA9 | CA9 | n/a | 53261165 | n/a | (1R,2S,3R)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethynyl]-2-methyl-cyclohex-4-ene-1,3-diol | n/a | |
| 17 | P11473_COV | COV | n/a | 16043216 | n/a | (1S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-9,10-secoandrosta-5,7,10-triene-1,3-diol | n/a | |
| 18 | P11473_DS2 | DS2 | n/a | 53470392 | n/a | {4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetic acid | n/a | |
| 19 | P11473_DS3 | DS3 | n/a | 53470393 | n/a | 5-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}pentanoic acid | n/a | |
| 20 | P11473_DS4 | DS4 | n/a | 15941994 | CHEMBL2348358 | [3-fluoro-2'-methyl-4'-(3-{3-methyl-4-[(1E)-4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)but-1-en-1-yl]phenyl}pentan-3-yl)biphenyl-4-yl]acetic acid | n/a | |
| 21 | P11473_DS5 | DS5 | n/a | 57432986 | CHEMBL2365283 | (4S)-4-hydroxy-5-[2-methyl-4-(3-{3-methyl-4-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)but-1-yn-1-yl]phenyl}pentan-3-yl)phenoxy]pentanoic acid | n/a | |
| 22 | P11473_DS6 | DS6 | n/a | 53470394 | n/a | (4S)-4-hydroxy-5-[4-(3-{4-[(3S)-3-hydroxy-4,4-dimethylpentyl]-3-methylphenyl}pentan-3-yl)-2-methylphenoxy]pentanoic acid | n/a | |
| 23 | P11473_EB1 | EB1 | DB04258 | 5288149 | CHEMBL1908376 | SEOCALCITOL | inhibitor | |
| 24 | P11473_ED9 | ED9 | DB05295 | 6918141 | CHEMBL4297608 | (1R,2R,3R,5Z,7E,14beta,17alpha)-2-(3-hydroxypropoxy)-9,10-secocholesta-5,7,10-triene-1,3,25-triol | n/a | |
| 25 | P11473_EIM | EIM | n/a | 44192388 | n/a | (1R,3S,5Z)-5-[(2E)-2-[(1R,3S,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-3-methoxy-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol | n/a | |
| 26 | P11473_FMV | FMV | n/a | 53313342 | n/a | (1S,3R,5Z,7E,14beta,17alpha,20S)-20-[5-(1-hydroxy-1-methylethyl)furan-2-yl]-9,10-secopregna-5,7,10-triene-1,3-diol | n/a | |
| 27 | P11473_KH1 | KH1 | DB03451 | 5288670 | CHEMBL432600 | 5-(2-{1-[1-(4-ETHYL-4-HYDROXY-HEXYLOXY)-ETHYL]-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE}-ETHYLIDENE)-4-METHYLENE-CYCLOHEXANE-1,3-DIOL | agonist | |
| 28 | P11473_MC9 | MC9 | DB02300 | 5288783 | CHEMBL1200666 | CALCIPOTRIOL | antagonist | Kd(nM) = 0.31 |
| 29 | P11473_MCZ | MCZ | DB06272 | 6398761 | CHEMBL333950 | (1S,3R,5Z,7E,14beta,17alpha,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol | n/a | |
| 30 | P11473_MVD | MVD | n/a | 5283797 | CHEMBL215541 | 2ALPHA-METHYL-1ALPHA,25-DIHYDROXY-VITAMIN D3 | n/a | |
| 31 | P11473_O1C | O1C | n/a | 10062746 | CHEMBL212940 | 2ALPHA-(3-HYDROXYPROPYL)-1ALPHA,25-DIHYDROXYVITAMIN D3 | n/a | |
| 32 | P11473_OCC | OCC | n/a | 9891771 | CHEMBL385658 | 2ALPHA-(3-HYDROXYPROPOXY)-1ALPHA,25-DIHYDROXYVITAMIN D3 | n/a | |
| 33 | P11473_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 34 | P11473_TEJ | TEJ | n/a | 45479714 | n/a | (1S,3R,5Z,7E,20S,23S)-1,3-dihydroxy-23,26-epoxy-9,10-secocholesta-5,7,10,25(27)-tetraen-26-one | n/a | |
| 35 | P11473_TEY | TEY | n/a | 71764798 | CHEMBL2407821 | (1R,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-2-[2-(1,2,3,4-tetrazol-2-yl)ethyl]cyclohexane-1,3-diol | n/a | |
| 36 | P11473_TFY | TFY | n/a | 71764799 | CHEMBL2407822 | (1R,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-2-[2-(1,2,3,4-tetrazol-1-yl)ethyl]cyclohexane-1,3-diol | n/a | |
| 37 | P11473_TX5 | TX5 | DB04796 | 5289504 | n/a | (1R,3R)-5-((Z)-2-((1R,7AS)-HEXAHYDRO-1-((S)-6-HYDROXY-6-METHYLHEPT-4-YN-2-YL)-7A-METHYL-1H-INDEN-4(7AH)-YLIDENE)ETHYLIDENE)CYCLOHEXANE-1,3-DIOL | agonist | |
| 38 | P11473_VDX | VDX | DB00136 | 5280453 | CHEMBL846 | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL | agonist | IC50(nM) = 0.04 Kd(nM) = 0.065 EC50(nM) = 0.01 |
| 39 | P11473_VHW | VHW | n/a | 70789249 | n/a | methyl (1S,3E)-3-{(2R)-2-[(1R,3aS,4E,7aR)-4-{(2Z)-2-[(3R,4S,5R)-3,5-dihydroxy-4-(3-hydroxypropoxy)-2-methylidenecyclohexylidene]ethylidene}-7a-methyloctahydro-1H-inden-1-yl]propylidene}-1-ethyl-2-oxocyclopentanecarboxylate (non-preferred name) | n/a | |
| 40 | P11473_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 41 | P11473_ZNE | ZNE | n/a | 138753372 | n/a | (1R,3S,5Z)-5-[(2E)-2-{(1R,3aS,7aR)-1-[(1R,5S)-5-hydroxy-1-methyl-5-(1,3-thiazol-2-yl)pentyl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexane-1,3-diol | n/a | |
| 42 | P11473_ZYD | ZYD | n/a | 11258570 | n/a | (1R,3S,5Z)-5-{(2E)-2-[(3aR,7aS)-7a-(7-hydroxy-7-methyloctyl)octahydro-4H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol | n/a | |
| 43 | P11473_VDY | VDY | DB00146 | 5283731 | CHEMBL1040 | Calcifediol | agonist | |
| 44 | P11473_D2V | D2V | DB00153 | 5280793 | CHEMBL1536 | Ergocalciferol | agonist | |
| 45 | P11473_DB00169 | n/a | DB00169 | n/a | n/a | Cholecalciferol | agonist | IC50(nM) = 87.0 EC50(nM) = 0.21 |
| 46 | P11473_DB00910 | n/a | DB00910 | n/a | n/a | Paricalcitol | agonist | |
| 47 | P11473_DB01070 | n/a | DB01070 | n/a | n/a | Dihydrotachysterol | agonist | |
| 48 | P11473_M9B | M9B | DB01436 | 5282181 | CHEMBL1601669 | Alfacalcidol | agonist | |
| 49 | P11473_CLR | CLR | DB04540 | 5997 | CHEMBL112570 | Cholesterol | n/a | |
| 50 | P11473_DB04796 | n/a | DB04796 | n/a | n/a | Inecalcitol | agonist | |
| 51 | P11473_VD1 | VD1 | DB04891 | 5289547 | CHEMBL2104955 | Becocalcidiol | n/a | |
| 52 | P11473_DB06194 | n/a | DB06194 | n/a | n/a | Elocalcitol | agonist | |
| 53 | P11473_V2H | V2H | DB06410 | 5281107 | CHEMBL1200810 | Doxercalciferol | suppressor | |
| 54 | P11473_C5D | C5D | DB07530 | 10457944 | n/a | (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol | n/a | |
| 55 | P11473_XE4 | XE4 | DB08742 | 11269429 | n/a | 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) | n/a | |
| 56 | P11473_CC9 | CC9 | DB11672 | 969516 | CHEMBL140 | Curcumin | n/a | |
| 57 | P11473_DB14635 | n/a | DB14635 | n/a | n/a | Curcumin sulfate | n/a |