Gene name: ACE
Protein name: Angiotensin-converting enzyme (ACE)
List of molecules and drugs that interact with protein P12821
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P12821_12P | 12P | n/a | 81248 | n/a | DODECAETHYLENE GLYCOL | n/a | |
| 2 | P12821_1IU | 1IU | n/a | 71710890 | n/a | [3-[[(2S)-1-azanyl-1-oxidanylidene-propan-2-yl]amino]-2-methyl-3-oxidanylidene-propyl]-[(1R)-1-[[(2R)-2-azanyl-3-(1H-1,2,3,4-tetrazol-5-yl)propanoyl]amino]-2-phenyl-ethyl]phosphinic acid | n/a | |
| 3 | P12821_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 4 | P12821_2PE | 2PE | n/a | 4867 | n/a | NONAETHYLENE GLYCOL | n/a | |
| 5 | P12821_3EF | 3EF | n/a | 44626711 | CHEMBL570732 | N-{(2S)-3-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine | n/a | |
| 6 | P12821_3ES | 3ES | n/a | 11556698 | CHEMBL570953 | [(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-{[(BENZYLOXY)[(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-CARBONYL]-AMINO}ETHYL)PHOSPHINYL]-2-[(3-PHENYLISOXAZOL-5-YL)METHYL]-1-OXO-PROPYL}AMINO)-3-(4-HYDROXY-PHENYL) | n/a | |
| 7 | P12821_8J9 | 8J9 | n/a | 162624756 | CHEMBL5077796 | (2~{S})-2-[[(2~{S})-1-[[(2~{S})-3-(4-hydroxyphenyl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]amino]-4-phenyl-butanoic acid | n/a | |
| 8 | P12821_8JV | 8JV | n/a | 162624757 | CHEMBL5075686 | (2~{S},5~{R})-5-(4-methylphenyl)-1-[2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-4-phenyl-butan-2-yl]amino]ethanoyl]pyrrolidine-2-carboxylic acid | n/a | |
| 9 | P12821_8KC | 8KC | n/a | 162624755 | CHEMBL5075705 | (2~{S})-2-[[(2~{S})-1-[[(2~{S})-3-(1~{H}-indol-3-yl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]amino]-4-phenyl-butanoic acid | n/a | |
| 10 | P12821_9X6 | 9X6 | n/a | 31277 | CHEMBL1570500 | thiodiglycolic acid | n/a | |
| 11 | P12821_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | inhibitor | |
| 12 | P12821_ASP | ASP | DB00128 | 5960;44367445;139060126; | CHEMBL274323 | ASPARTIC ACID | n/a | |
| 13 | P12821_BCN | BCN | DB03709 | 8761;5256512; | CHEMBL1231251 | BICINE | n/a | |
| 14 | P12821_BJ2 | BJ2 | n/a | 131953530 | CHEMBL4068536 | (2~{S})-1-[(2~{S})-2-[[(1~{S})-1-[(2~{S})-1-[(2~{S})-2-azanyl-4-oxidanyl-4-oxidanylidene-butanoyl]pyrrolidin-2-yl]-2-oxidanyl-2-oxidanylidene-ethyl]amino]propanoyl]pyrrolidine-2-carboxylic acid | n/a | |
| 15 | P12821_BMA | BMA | n/a | 439680 | n/a | beta-D-mannopyranose | n/a | |
| 16 | P12821_BO3 | BO3 | DB11326 | 7628 | CHEMBL42403 | BORIC ACID | n/a | |
| 17 | P12821_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | P12821_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 19 | P12821_D0W | D0W | n/a | 132451821 | CHEMBL4462603 | Sampatrilat-Asp | n/a | |
| 20 | P12821_D0Z | D0Z | n/a | 6324648 | CHEMBL42583 | Sampatrilat | n/a | |
| 21 | P12821_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | P12821_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 23 | P12821_FT8 | FT8 | DB00886 | 656629 | CHEMBL289556 | Omapatrilat | modulator | |
| 24 | P12821_FUC | FUC | DB04473 | 439554 | CHEMBL1232862 | alpha-L-fucopyranose | n/a | |
| 25 | P12821_GLN | GLN | DB00130 | 5961;6992086; | CHEMBL930 | GLUTAMINE | n/a | |
| 26 | P12821_GLU | GLU | DB00142 | 33032;44272391;88747398; | CHEMBL575060 | GLUTAMIC ACID | n/a | |
| 27 | P12821_GLY | GLY | DB00145 | 750;5257127; | CHEMBL773 | GLYCINE | n/a | |
| 28 | P12821_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 29 | P12821_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
| 30 | P12821_K26 | K26 | n/a | 18608377 | CHEMBL1233799 | N-ACETYL-L-ILE-L-TYR-(R)-1-AMINO-2-(4-HYDROXYPHENYL)ETHYLPHOSPHONIC ACID | n/a | |
| 31 | P12821_KAF | KAF | n/a | 24808492 | n/a | N-{(5S)-4,4-dihydroxy-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl}-L-phenylalanine | n/a | |
| 32 | P12821_KAW | KAW | n/a | 24808493 | n/a | N-{(5S)-4,4-dihydroxy-6-phenyl-5-[(phenylcarbonyl)amino]hexanoyl}-L-tryptophan | n/a | |
| 33 | P12821_KS8 | KS8 | DB14207 | 62956 | CHEMBL581 | fosinoprilat | n/a | |
| 34 | P12821_LSW | LSW | n/a | 16007169;72200141; | CHEMBL212710 | N~2~-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-tryptophan | n/a | |
| 35 | P12821_LYS | LYS | DB00123 | 641599;5460926;24848423;162317967; | n/a | LYSINE | n/a | |
| 36 | P12821_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 37 | P12821_MLA | MLA | DB02175 | 867;23511544; | CHEMBL7942 | MALONIC ACID | n/a | |
| 38 | P12821_MXE | MXE | DB02806 | 8019 | CHEMBL444144 | 2-METHOXYETHANOL | n/a | |
| 39 | P12821_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 40 | P12821_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 41 | P12821_NIY | NIY | DB03867 | 65124;51671208; | CHEMBL1234745 | META-NITRO-TYROSINE | n/a | |
| 42 | P12821_P33 | P33 | DB03394 | 79718 | n/a | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL | n/a | |
| 43 | P12821_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
| 44 | P12821_PE3 | PE3 | n/a | 656926 | n/a | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL | n/a | |
| 45 | P12821_PE4 | PE4 | n/a | 448032 | n/a | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL | n/a | |
| 46 | P12821_PE8 | PE8 | n/a | 78798 | n/a | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL | n/a | |
| 47 | P12821_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 48 | P12821_PG0 | PG0 | n/a | 8134 | CHEMBL1235250 | 2-(2-METHOXYETHOXY)ETHANOL | n/a | |
| 49 | P12821_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 50 | P12821_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 51 | P12821_PRO | PRO | DB00172 | 145742;6971047; | CHEMBL54922 | PROLINE | n/a | Ki(nM) = 86000.0 |
| 52 | P12821_RX3 | RX3 | n/a | 45485266 | CHEMBL571716 | N-({(1S,2R)-2-[(S)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL](HYDROXY)PHOSPHORYL]CYCLOPENTYL}CARBONYL)-L-TRYPT OPHAN | n/a | |
| 53 | P12821_RX4 | RX4 | n/a | 9827219 | CHEMBL1235767 | N~2~-acetyl-N-{(1R)-1-[(S)-[(2S)-3-{[(2S)-1-amino-1-oxopropan-2-yl]amino}-2-methyl-3-oxopropyl](hydroxy)phosphoryl]-2-phenylethyl}-L-alpha-asparagine | n/a | |
| 54 | P12821_SAC | SAC | DB02340 | 65249 | n/a | N-ACETYL-SERINE | n/a | |
| 55 | P12821_SER | SER | DB00133 | 5951;6857581; | CHEMBL11298 | SERINE | n/a | |
| 56 | P12821_SLC | SLC | n/a | n/a | n/a | SELENO-CAPTOPRIL | n/a | |
| 57 | P12821_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 58 | P12821_VAL | VAL | DB00161 | 6287;6971018;88733505; | CHEMBL43068 | VALINE | n/a | |
| 59 | P12821_X8Z | X8Z | DB01197 | 44093;12851888; | CHEMBL1560 | L-CAPTOPRIL | inhibitor | Ki(nM) = 2.0 IC50(nM) = 0.12 EC50(nM) = 18540.0 |
| 60 | P12821_XPE | XPE | n/a | 79689 | n/a | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL | n/a | |
| 61 | P12821_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 62 | P12821_DB00178 | n/a | DB00178 | n/a | n/a | Ramipril | inhibitor | IC50(nM) = 4.0 |
| 63 | P12821_DB00492 | n/a | DB00492 | n/a | n/a | Fosinopril | inhibitor | |
| 64 | P12821_DB00519 | n/a | DB00519 | n/a | n/a | Trandolapril | inhibitor | IC50(nM) = 0.93 |
| 65 | P12821_DB00542 | n/a | DB00542 | n/a | n/a | Benazepril | inhibitor | IC50(nM) = 1.7 |
| 66 | P12821_DB00584 | n/a | DB00584 | n/a | n/a | Enalapril | inhibitor | IC50(nM) = 4.5 |
| 67 | P12821_DB00616 | n/a | DB00616 | n/a | n/a | Candoxatril | inhibitor | |
| 68 | P12821_DB00691 | n/a | DB00691 | n/a | n/a | Moexipril | inhibitor | IC50(nM) = 2.6 |
| 69 | P12821_LPR | LPR | DB00722 | 5362119;11865407;139146300; | CHEMBL1237 | Lisinopril | inhibitor | Ki(nM) = 1.2 IC50(nM) = 0.1 |
| 70 | P12821_DB00790 | n/a | DB00790 | n/a | n/a | Perindopril | inhibitor | |
| 71 | P12821_DB00881 | n/a | DB00881 | n/a | n/a | Quinapril | inhibitor | IC50(nM) = 8.3 |
| 72 | P12821_DB01180 | n/a | DB01180 | n/a | n/a | Rescinnamine | inhibitor | |
| 73 | P12821_DB01340 | n/a | DB01340 | n/a | n/a | Cilazapril | inhibitor | |
| 74 | P12821_DB01348 | n/a | DB01348 | n/a | n/a | Spirapril | inhibitor | |
| 75 | P12821_DB02032 | n/a | DB02032 | n/a | n/a | Epicaptopril | n/a | |
| 76 | P12821_NDG | NDG | DB03740 | 82313 | CHEMBL1234669 | N-acetyl-alpha-D-glucosamine | inhibitor | |
| 77 | P12821_DB08836 | n/a | DB08836 | n/a | n/a | Temocapril | inhibitor | |
| 78 | P12821_EAL | EAL | DB09477 | 5462501 | CHEMBL577 | Enalaprilat | inhibitor | |
| 79 | P12821_DB13166 | n/a | DB13166 | n/a | n/a | Zofenopril | inhibitor | |
| 80 | P12821_DB15565 | n/a | DB15565 | n/a | n/a | Cilazaprilat | n/a |