Gene name: SRC
Protein name: Proto-oncogene tyrosine-protein kinase
List of molecules and drugs that interact with protein P12931
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P12931_0J9 | 0J9 | n/a | 4877 | CHEMBL264406 | 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 2 | P12931_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | inhibitor | IC50(nM) = 2.5 |
| 3 | P12931_197 | 197 | DB03268 | 5287443 | CHEMBL358866 | 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID | inhibitor | |
| 4 | P12931_219 | 219 | DB03114 | 5287461 | CHEMBL24811 | cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate | inhibitor | |
| 5 | P12931_24A | 24A | n/a | n/a | CHEMBL1084268 | {[(4-{[2-(4-AMINOCYCLOHEXYL)-9-ETHYL-9H-PURIN-6-YL]AMINO}PHENYL)(HYDROXY)PHOSPHORYL]METHYL}PHOSPHONIC ACID | n/a | |
| 6 | P12931_256 | 256 | DB01866 | 447536 | n/a | PHENYL(SULFO)ACETIC ACID | inhibitor | |
| 7 | P12931_262 | 262 | DB01947 | 5287463 | CHEMBL286678 | 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE | inhibitor | IC50(nM) = 80000.0 |
| 8 | P12931_299 | 299 | DB03828 | 5287465 | CHEMBL421138 | 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE | inhibitor | IC50(nM) = 39000.0 |
| 9 | P12931_300 | 300 | DB03306 | 5287488 | CHEMBL25186 | 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE | inhibitor | IC50(nM) = 95000.0 |
| 10 | P12931_493 | 493 | DB01908 | 5287515 | CHEMBL436462 | {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID | inhibitor | |
| 11 | P12931_687 | 687 | DB01678 | 5287544 | CHEMBL78455 | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE | inhibitor | |
| 12 | P12931_6H3 | 6H3 | n/a | 134130572 | CHEMBL3884293 | N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | n/a | |
| 13 | P12931_772 | 772 | DB02762 | 447532 | CHEMBL149603 | 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE | inhibitor | IC50(nM) = 3600000.0 |
| 14 | P12931_787 | 787 | DB02908 | 447537 | CHEMBL148732 | (PHENYL-PHOSPHONO-METHYL)-PHOSPHONIC ACID | inhibitor | IC50(nM) = 3900000.0 |
| 15 | P12931_790 | 790 | DB03525 | 5287550 | CHEMBL358860 | 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE | inhibitor | IC50(nM) = 300000.0 |
| 16 | P12931_791 | 791 | DB04080 | 75791 | CHEMBL78794 | 2-PHENYLMALONIC ACID | inhibitor | IC50(nM) = 200000.0 |
| 17 | P12931_821 | 821 | DB03104 | 5287555 | CHEMBL356002 | [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET IC ACID | inhibitor | |
| 18 | P12931_822 | 822 | DB03591 | 447523 | CHEMBL1160756 | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE | inhibitor | |
| 19 | P12931_843 | 843 | DB04495 | 447518 | CHEMBL25826 | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE | inhibitor | |
| 20 | P12931_852 | 852 | n/a | 447520 | CHEMBL421518 | 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID | n/a | |
| 21 | P12931_853 | 853 | DB03712 | 447524 | CHEMBL432359 | 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID | inhibitor | |
| 22 | P12931_876 | 876 | DB02336 | 447527 | CHEMBL319516 | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE | inhibitor | |
| 23 | P12931_903 | 903 | DB02432 | 447522 | CHEMBL357488 | 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID | inhibitor | |
| 24 | P12931_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 25 | P12931_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
| 26 | P12931_DB8 | DB8 | DB06616 | 5328940 | CHEMBL288441 | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | inhibitor | IC50(nM) = 1.0 Kd(nM) = 1.0 |
| 27 | P12931_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 28 | P12931_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 29 | P12931_H8H | H8H | DB11805 | 10302451 | CHEMBL217092 | N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE | modulator | |
| 30 | P12931_HET | HET | n/a | 9934643 | CHEMBL1089405 | 3-[2-(2-CYCLOPENTYL-6-{[4-(DIMETHYLPHOSPHORYL)PHENYL]AMINO}-9H-PURIN-9-YL)ETHYL]PHENOL | n/a | |
| 31 | P12931_HPS | HPS | DB03298 | 12793 | CHEMBL26128 | PHENYL DIHYDROGEN PHOSPHATE | inhibitor | IC50(nM) = 300000.0 |
| 32 | P12931_HVY | HVY | n/a | 138857405 | CHEMBL4548584 | N-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | n/a | |
| 33 | P12931_I59 | I59 | DB03217 | 447531 | n/a | HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID | inhibitor | |
| 34 | P12931_IS2 | IS2 | DB03628 | 447534 | CHEMBL284362 | [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID | inhibitor | IC50(nM) = 4400000.0 |
| 35 | P12931_L1N | L1N | n/a | n/a | n/a | 4-[(~{E})-(7-oxidanyl-6~{H}-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]-~{N}-pyridin-2-yl-benzenesulfonamide | n/a | |
| 36 | P12931_MLA | MLA | DB02175 | 867;23511544; | CHEMBL7942 | MALONIC ACID | n/a | IC50(nM) = 4.0E7 |
| 37 | P12931_MPZ | MPZ | DB04739 | 4369496 | CHEMBL56904 | 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE | n/a | IC50(nM) = 7800.0 |
| 38 | P12931_NBS | NBS | DB01893 | 446795 | CHEMBL1234640 | N6-BENZYL ADENOSINE-5'-DIPHOSPHATE | inhibitor | |
| 39 | P12931_OXD | OXD | DB03902 | 971;3819775;18676629; | CHEMBL146755 | OXALIC ACID | inhibitor | |
| 40 | P12931_P01 | P01 | DB04751 | 456214 | CHEMBL23327 | 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL | n/a | IC50(nM) = 240.0 |
| 41 | P12931_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 42 | P12931_PSN | PSN | DB03078 | 5289215 | CHEMBL148630 | BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE | inhibitor | |
| 43 | P12931_PTR | PTR | DB01962 | 30819 | CHEMBL286939 | O-PHOSPHOTYROSINE | inhibitor | |
| 44 | P12931_S03 | S03 | n/a | 5494445 | n/a | 1-{4-[4-AMINO-5-(3-METHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL]BENZYL}PIPERIDIN-4-OL | n/a | |
| 45 | P12931_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 46 | P12931_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 47 | P12931_UCW | UCW | n/a | 121231408 | CHEMBL3824089 | tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino)piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate | n/a | |
| 48 | P12931_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 49 | P12931_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | Dasatinib | inhibitor | Ki(nM) = 0.016 IC50(nM) = 0.21 Kd(nM) = 0.21 |
| 50 | P12931_PP2 | PP2 | DB03023 | n/a | n/a | 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine | n/a | |
| 51 | P12931_DN0 | DN0 | DB06137 | 23635314 | CHEMBL571546 | Tirbanibulin | inhibitor | |
| 52 | P12931_1AU | 1AU | DB06882 | 25174101 | CHEMBL522387 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea | n/a | |
| 53 | P12931_1AW | 1AW | DB06883 | 10915062 | CHEMBL87580 | 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea | n/a | |
| 54 | P12931_ABJ | ABJ | DB07335 | 24905143 | CHEMBL1230790 | 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL | n/a | |
| 55 | P12931_DJK | DJK | DB07662 | 4708 | CHEMBL285063 | PD-168393 | n/a | IC50(nM) = 27000.0 |
| 56 | P12931_IHH | IHH | DB07966 | 16040294 | n/a | [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | n/a | |
| 57 | P12931_KS1 | KS1 | DB08052 | 24905142 | CHEMBL1081312 | PP-121 | inhibitor | IC50(nM) = 14.0 |
| 58 | P12931_KS4 | KS4 | DB08053 | 24905153 | CHEMBL1233881 | 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | IC50(nM) = 170.0 |
| 59 | P12931_KS5 | KS5 | DB08054 | 24905152 | CHEMBL1233882 | 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 60 | P12931_MN8 | MN8 | DB08192 | n/a | n/a | 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE | inhibitor | |
| 61 | P12931_RBS | RBS | DB08462 | 10401956 | CHEMBL1221699 | N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE | inhibitor | IC50(nM) = 27000.0 |
| 62 | P12931_SR2 | SR2 | DB08564 | 5328969 | CHEMBL94061 | (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide | n/a | |
| 63 | P12931_XIN | XIN | DB09079 | 9809715 | CHEMBL502835 | Nintedanib | inhibitor | |
| 64 | P12931_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |