Gene name: FDPS
Protein name: Farnesyl pyrophosphate synthase
List of molecules and drugs that interact with protein P14324
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P14324_11P | 11P | n/a | 16750107 | n/a | [(7R)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) | n/a | |
| 2 | P14324_1MV | 1MV | n/a | 71583208 | CHEMBL2347862 | ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid) | n/a | |
| 3 | P14324_1WO | 1WO | n/a | 73588 | CHEMBL235195 | (5beta)-11-hydroxyabieta-7,9(11),13-triene-6,12-dione | n/a | |
| 4 | P14324_1XH | 1XH | n/a | 457196 | n/a | 2-{[(1S,2R,4aS,8aR)-1,2,4a-trimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl}cyclohexa-2,5-diene-1,4-dione | n/a | |
| 5 | P14324_210 | 210 | DB00282 | 4674;44400012; | CHEMBL834 | PAMIDRONATE | inhibitor | Ki(nM) = 55.9 IC50(nM) = 200.0 |
| 6 | P14324_39L | 39L | n/a | 45137878 | n/a | [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid) | n/a | |
| 7 | P14324_3F2 | 3F2 | n/a | 413628 | CHEMBL3410452 | N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]biphenyl-4,4'-dicarboxamide | n/a | |
| 8 | P14324_3N1 | 3N1 | n/a | 68686 | CHEMBL1230158 | (5-chloro-3-methyl-1-benzothiophen-2-yl)acetic acid | n/a | |
| 9 | P14324_3N2 | 3N2 | n/a | 205058 | CHEMBL1230159 | (5-chloro-1-benzothiophen-3-yl)acetic acid | n/a | |
| 10 | P14324_3N3 | 3N3 | n/a | 6932064 | CHEMBL1230160 | (2S)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid | n/a | |
| 11 | P14324_3N4 | 3N4 | n/a | 46398844 | n/a | naphtho[2,1-b]thiophen-1-ylacetic acid | n/a | |
| 12 | P14324_3N5 | 3N5 | n/a | 6932062 | CHEMBL551821 | (2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid | n/a | |
| 13 | P14324_4GA | 4GA | n/a | 71306454 | n/a | 1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium | n/a | |
| 14 | P14324_59Y | 59Y | n/a | 44207265 | n/a | 8-(naphthalen-1-yl)quinoline-2-carboxylic acid | n/a | |
| 15 | P14324_59Z | 59Z | n/a | 121231461 | n/a | {2-[(phosphonomethyl)carbamoyl]-1H-benzo[g]indol-1-yl}acetic acid | n/a | |
| 16 | P14324_5A7 | 5A7 | n/a | 44208616 | n/a | {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid | n/a | |
| 17 | P14324_5B9 | 5B9 | n/a | 17604131 | n/a | 2-(naphthalen-1-ylmethoxy)benzoic acid | n/a | |
| 18 | P14324_5BJ | 5BJ | n/a | 91885647 | n/a | 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid | n/a | |
| 19 | P14324_5BK | 5BK | n/a | 91885648 | n/a | 1H,1'H-4,4'-biindole-2-carboxylic acid | n/a | |
| 20 | P14324_5BL | 5BL | n/a | 44208411 | n/a | 8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid | n/a | |
| 21 | P14324_6O3 | 6O3 | n/a | 124220688 | CHEMBL4093973 | {[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-5-yl]methyl}phosphonic acid | n/a | |
| 22 | P14324_7AM | 7AM | n/a | 124220689 | CHEMBL4094213 | [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid | n/a | |
| 23 | P14324_AHD | AHD | n/a | 5459353 | n/a | 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE | n/a | |
| 24 | P14324_BFH | BFH | n/a | 46398840 | CHEMBL1231307 | 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid | n/a | |
| 25 | P14324_BFQ | BFQ | DB00710 | 60852;146015366; | CHEMBL997 | IBANDRONATE | inhibitor | Ki(nM) = 3.6 IC50(nM) = 20.0 |
| 26 | P14324_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 27 | P14324_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 28 | P14324_FPP | FPP | DB07780 | 445713 | CHEMBL69330 | FARNESYL DIPHOSPHATE | n/a | |
| 29 | P14324_GO0 | GO0 | n/a | 46398841 | n/a | 3-(carboxymethyl)-4,7-dichloro-1H-indole-2-carboxylic acid | n/a | |
| 30 | P14324_GO1 | GO1 | n/a | 46398845 | n/a | 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid | n/a | |
| 31 | P14324_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 32 | P14324_IPE | IPE | DB04714 | 1195 | CHEMBL356362 | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | inhibitor | |
| 33 | P14324_IPR | IPR | DB02508 | 448400 | n/a | ISOPENTYL PYROPHOSPHATE | inhibitor | |
| 34 | P14324_JD1 | JD1 | n/a | 70697411 | CHEMBL2088338 | [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) | n/a | |
| 35 | P14324_JD5 | JD5 | n/a | 70691191 | CHEMBL2088339 | [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) | n/a | |
| 36 | P14324_KF7 | KF7 | n/a | 90185749 | CHEMBL4100337 | [(1S)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid | n/a | |
| 37 | P14324_KFA | KFA | n/a | 90185767 | CHEMBL4090167 | [(1R)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid | n/a | |
| 38 | P14324_M0N | M0N | DB06548 | 130956 | CHEMBL319144 | (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID) | inhibitor | |
| 39 | P14324_M2V | M2V | n/a | 90185765 | CHEMBL4467922 | [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid | n/a | |
| 40 | P14324_M2Y | M2Y | n/a | 139592518 | CHEMBL4448870 | [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid | n/a | |
| 41 | P14324_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 42 | P14324_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 43 | P14324_MS0 | MS0 | n/a | 736818 | CHEMBL1234470 | (6-methoxy-1-benzofuran-3-yl)acetic acid | n/a | |
| 44 | P14324_N1Z | N1Z | n/a | 71624063;137349775; | CHEMBL2338360 | hydrogen [(1S)-1-hydroxy-2-(3-octyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | n/a | |
| 45 | P14324_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
| 46 | P14324_NI9 | NI9 | n/a | 11266583 | n/a | 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM | n/a | |
| 47 | P14324_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 48 | P14324_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 49 | P14324_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 50 | P14324_POP | POP | n/a | 4995;18628280;57345951; | n/a | PYROPHOSPHATE 2- | n/a | |
| 51 | P14324_RIS | RIS | DB00884 | 5245;44400168; | CHEMBL923 | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID | inhibitor | Ki(nM) = 0.36 IC50(nM) = 0.36 |
| 52 | P14324_RSX | RSX | n/a | 24764446 | n/a | (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid) | n/a | |
| 53 | P14324_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 54 | P14324_UNR | UNR | n/a | |||||
| 55 | P14324_UNV | UNV | n/a | |||||
| 56 | P14324_WC1 | WC1 | n/a | 90642936 | n/a | (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid) | n/a | |
| 57 | P14324_YF7 | YF7 | n/a | 139592509 | CHEMBL4516343 | [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid | n/a | |
| 58 | P14324_YL2 | YL2 | n/a | 72376503 | CHEMBL3087937 | ({[6-(4-cyclopropylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid) | n/a | |
| 59 | P14324_YL3 | YL3 | n/a | 74766013 | CHEMBL3299047 | ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl)phosphonic acid | n/a | |
| 60 | P14324_YL4 | YL4 | n/a | 124220685 | n/a | [(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid | n/a | |
| 61 | P14324_YL5 | YL5 | n/a | 124220686 | CHEMBL4550499 | [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid | n/a | |
| 62 | P14324_YL6 | YL6 | n/a | 124220687 | CHEMBL4515661 | [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid | n/a | |
| 63 | P14324_YS1 | YS1 | n/a | 70687003 | CHEMBL2088336 | [({4-[4-(cyclopropyloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) | n/a | |
| 64 | P14324_YS4 | YS4 | n/a | 54674305 | CHEMBL2048241 | [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) | n/a | |
| 65 | P14324_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 66 | P14324_ZOL | ZOL | DB00399 | 68740 | CHEMBL924 | ZOLEDRONIC ACID | inhibitor | Ki(nM) = 0.07 IC50(nM) = 0.24 |
| 67 | P14324_SUF | SUF | n/a | n/a | n/a | [2-(DIMETHYL-LAMBDA~4~-SULFANYL)-1-HYDROXYETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID) | n/a | |
| 68 | P14324_T93 | T93 | n/a | 134817490 | n/a | [[(4-hexoxypyridin-2-yl)amino]-phosphono-methyl]phosphonic acid | n/a | |
| 69 | P14324_212 | 212 | DB00630 | 2088;44400013; | CHEMBL870 | Alendronic acid | inhibitor | Ki(nM) = 44.2 IC50(nM) = 50.0 |
| 70 | P14324_DMA | DMA | DB01785 | 647 | CHEMBL343480 | Dimethylallyl Diphosphate | inhibitor | |
| 71 | P14324_GPP | GPP | DB02552 | 445995 | CHEMBL41342 | Geranyl Diphosphate | inhibitor | |
| 72 | P14324_DB06255 | n/a | DB06255 | n/a | n/a | Incadronic acid | inhibitor | |
| 73 | P14324_BUE | BUE | DB07841 | 735 | n/a | Geranylgeranyl diphosphate | inhibitor |