Gene name: BRAF
Protein name: Serine/threonine-protein kinase B-raf
List of molecules and drugs that interact with protein P15056
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P15056_032 | 032 | DB08881 | 42611257 | CHEMBL1229517 | N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | inhibitor | IC50(nM) = 4.0 Kd(nM) = 10.0 EC50(nM) = 601.0 |
| 2 | P15056_0JA | 0JA | n/a | 25206185 | CHEMBL2063743 | 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | n/a | |
| 3 | P15056_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | n/a | |
| 4 | P15056_0NF | 0NF | n/a | 50937465 | CHEMBL1614728 | (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide | n/a | |
| 5 | P15056_0T2 | 0T2 | n/a | 25206346 | CHEMBL2204532 | 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide | n/a | |
| 6 | P15056_0WP | 0WP | n/a | 66563698 | CHEMBL2153510 | 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)benzamide | n/a | |
| 7 | P15056_10Z | 10Z | n/a | 70702306 | CHEMBL2335881 | N-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine | n/a | |
| 8 | P15056_1OO | 1OO | n/a | 16048801 | n/a | N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide | n/a | |
| 9 | P15056_1SU | 1SU | n/a | 46209401 | CHEMBL3125890 | N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | n/a | |
| 10 | P15056_1SW | 1SW | n/a | 71627417 | CHEMBL3125885 | N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | n/a | |
| 11 | P15056_215 | 215 | n/a | 135398506 | CHEMBL200622 | (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME | n/a | |
| 12 | P15056_29L | 29L | n/a | 11717001 | CHEMBL525191 | 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol | n/a | |
| 13 | P15056_2VX | 2VX | n/a | 60196913 | CHEMBL3236466 | N-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide | n/a | |
| 14 | P15056_324 | 324 | DB06999 | 24180719 | CHEMBL1230020 | N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | inhibitor | Ki(nM) = 2.6 IC50(nM) = 13.0 Kd(nM) = 100.0 |
| 15 | P15056_325 | 325 | DB07000 | 24180720 | n/a | N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide | n/a | |
| 16 | P15056_3K3 | 3K3 | DB14773 | 89670174 | CHEMBL4209157 | 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one | inhibitor | |
| 17 | P15056_4EF | 4EF | n/a | 70649546 | CHEMBL3814798 | 3-[(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-(morpholin-4-yl)benzenesulfonamide | n/a | |
| 18 | P15056_4Z5 | 4Z5 | n/a | 71721540 | CHEMBL3577124 | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | n/a | |
| 19 | P15056_54J | 54J | DB18780 | 60152613 | CHEMBL4212692 | N-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide | n/a | |
| 20 | P15056_55J | 55J | DB05984 | 11656518 | CHEMBL558752 | 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine | n/a | |
| 21 | P15056_573 | 573 | n/a | 46926364 | CHEMBL2087078 | 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide | n/a | |
| 22 | P15056_5I4 | 5I4 | n/a | 156631274 | n/a | ~{N}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{S})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide | n/a | |
| 23 | P15056_5XJ | 5XJ | n/a | 118988423 | CHEMBL3798256 | 6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{H}-purine | n/a | |
| 24 | P15056_6DC | 6DC | n/a | 60197316 | CHEMBL3236464 | N-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide | n/a | |
| 25 | P15056_6FS | 6FS | DB12146 | 6918736 | CHEMBL1241855 | N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine | n/a | |
| 26 | P15056_6N9 | 6N9 | n/a | 58086298 | CHEMBL4870365 | N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide | n/a | |
| 27 | P15056_6NB | 6NB | n/a | 121596339 | n/a | N,N'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1H-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide) | n/a | |
| 28 | P15056_6NC | 6NC | n/a | 121596340 | CHEMBL4249291 | 2,2'-oxybis(N-{[4-(3-{2,6-difluoro-3-[(propane-1-sulfonyl)amino]benzoyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methyl}acetamide) | n/a | |
| 29 | P15056_734 | 734 | n/a | 1301419 | n/a | 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol | n/a | |
| 30 | P15056_831 | 831 | n/a | 24884503 | CHEMBL1087397 | N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide | n/a | |
| 31 | P15056_8EN | 8EN | n/a | 56929808 | CHEMBL4216073 | ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | n/a | |
| 32 | P15056_904 | 904 | n/a | 90116945 | CHEMBL4206836 | N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide | n/a | |
| 33 | P15056_92D | 92D | n/a | 129010136 | CHEMBL4081025 | N-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide | n/a | |
| 34 | P15056_92J | 92J | n/a | 90408826 | CHEMBL3962812 | N-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | n/a | |
| 35 | P15056_ACP | ACP | DB03909 | 91532 | CHEMBL133463 | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | n/a | |
| 36 | P15056_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 37 | P15056_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 38 | P15056_B0R | B0R | n/a | 44223206 | CHEMBL1822067 | 2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide | n/a | |
| 39 | P15056_B1E | B1E | n/a | 11676786 | CHEMBL2144069 | 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | n/a | |
| 40 | P15056_B96 | B96 | DB03044 | 156422 | CHEMBL103667 | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA | n/a | IC50(nM) = 83.4 Kd(nM) = 2700.0 |
| 41 | P15056_BAX | BAX | DB00398 | 216239 | CHEMBL1336 | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | inhibitor | Ki(nM) = 22.0 IC50(nM) = 4.4 Kd(nM) = 260.0 EC50(nM) = 3.0 |
| 42 | P15056_BEN | BEN | n/a | 2332 | CHEMBL20936 | BENZAMIDINE | n/a | |
| 43 | P15056_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 44 | P15056_BR2 | BR2 | n/a | 137349021 | n/a | 2,6-difluoro-N-[(5S)-3-methoxy-5H-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide | n/a | |
| 45 | P15056_CHU | CHU | DB15254 | 16719221 | CHEMBL3264002 | N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide | modulator | |
| 46 | P15056_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 47 | P15056_DFS | DFS | n/a | 44199417 | CHEMBL1945163 | 2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide | n/a | |
| 48 | P15056_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 49 | P15056_E7M | E7M | n/a | 154585730 | n/a | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 50 | P15056_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 51 | P15056_EOH | EOH | DB00898 | 702 | CHEMBL545 | ETHANOL | n/a | |
| 52 | P15056_EU4 | EU4 | n/a | 132275094 | CHEMBL4247506 | 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 53 | P15056_EUI | EUI | DB05239 | 16222096 | CHEMBL2146883 | [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE | n/a | |
| 54 | P15056_FNI | FNI | n/a | 16044861 | CHEMBL1614960 | 3-[(5-hydroxynaphthalen-2-yl)amino]-N-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide | n/a | |
| 55 | P15056_FOI | FOI | n/a | 52942827 | n/a | methyl 3-{[(5S)-1-(hydroxyamino)-5H-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate | n/a | |
| 56 | P15056_FP3 | FP3 | n/a | 49849970 | CHEMBL1614963 | 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol | n/a | |
| 57 | P15056_FP4 | FP4 | n/a | 49849971 | n/a | 3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1H-indazol-3-yl)propan-1-ol | n/a | |
| 58 | P15056_GLC | GLC | n/a | 79025 | CHEMBL423707 | alpha-D-glucopyranose | n/a | |
| 59 | P15056_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 60 | P15056_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 61 | P15056_K7S | K7S | n/a | 139267750 | n/a | N-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | n/a | |
| 62 | P15056_K81 | K81 | DB18865 | 90456533 | CHEMBL4583691 | N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | n/a | |
| 63 | P15056_KZP | KZP | n/a | 138403232 | CHEMBL4593051 | 5-[(4-amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine | n/a | |
| 64 | P15056_L1E | L1E | n/a | 44223999 | CHEMBL1197798 | N~1~-(4-chlorophenyl)-6-methyl-N~5~-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine | n/a | |
| 65 | P15056_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 66 | P15056_NH4 | NH4 | n/a | 223;16741146; | n/a | AMMONIUM ION | n/a | |
| 67 | P15056_NHE | NHE | DB03309 | 66898;3852474; | n/a | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | n/a | |
| 68 | P15056_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 69 | P15056_P02 | P02 | n/a | 91971376 | n/a | N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide | n/a | |
| 70 | P15056_P06 | P06 | DB08912 | 44462760 | CHEMBL2028663 | Dabrafenib | inhibitor | IC50(nM) = 0.4 EC50(nM) = 0.7 |
| 71 | P15056_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 72 | P15056_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 73 | P15056_QH1 | QH1 | n/a | 142574745 | n/a | N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide | n/a | |
| 74 | P15056_QOM | QOM | DB08911 | 11707110 | CHEMBL2103875 | Trametinib | n/a | |
| 75 | P15056_QOP | QOP | DB15266 | 25161177 | CHEMBL3348923 | 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide | inhibitor | |
| 76 | P15056_RI8 | RI8 | n/a | 50995710 | CHEMBL2047876 | 4-amino-N-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide | n/a | |
| 77 | P15056_RI9 | RI9 | n/a | 57342892 | CHEMBL2047869 | N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide | n/a | |
| 78 | P15056_RSW | RSW | n/a | n/a | n/a | [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) | n/a | |
| 79 | P15056_SM5 | SM5 | DB08553 | 11653652 | CHEMBL526479 | (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime | n/a | IC50(nM) = 0.03 |
| 80 | P15056_SM6 | SM6 | n/a | 52942837 | n/a | ethyl 3-{[1-(hydroxyamino)-2H-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate | n/a | |
| 81 | P15056_SM7 | SM7 | n/a | 53320288 | n/a | 6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]indeno[1,2-c]pyrazole | n/a | |
| 82 | P15056_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 83 | P15056_TMA | TMA | DB03095 | 6380 | CHEMBL46486 | TETRAMETHYLAMMONIUM ION | n/a | |
| 84 | P15056_TV4 | TV4 | n/a | 44217243 | CHEMBL1945020 | N-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamide | n/a | |
| 85 | P15056_TXV | TXV | n/a | 166625071 | CHEMBL5440746 | ~{N}-[3-[(5-chloranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide | n/a | |
| 86 | P15056_V5J | V5J | n/a | 155920128 | CHEMBL4778419 | 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide | n/a | |
| 87 | P15056_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 88 | P15056_T1Q | T1Q | n/a | 56955962 | CHEMBL2023498 | N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide | n/a | |
| 89 | P15056_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | IC50(nM) = 1.5 |
| 90 | P15056_DB11718 | n/a | DB11718 | n/a | n/a | Encorafenib | inhibitor | |
| 91 | P15056_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 92 | P15056_DB14840 | n/a | DB14840 | n/a | n/a | Ripretinib | inhibitor |